Search Results

Overview

Uniprot IDQ8IX01
Protein NameSURP and G-patch domain-containing protein 2
Gene NameSUGP2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1035 HGLGSLGKGIREPVS
18 FDAVLQEKAKRYHMD
238 TQGLLTAKGGVGKLV
243 TAKGGVGKLVTLRNV
253 TLRNVSTKKIPTVNR
264 TVNRITPKTQGTNQI
273 QGTNQIQKNTPSPDV
305 IPLGLDLKNLRLPRR
313 NLRLPRRKMSFDIID
959 RISSKSLKVGMIPAP

Function

May play a role in mRNA splicing

Protein Sequence

10 MAARRITQET 20 FDAVLQEKAK 30 RYHMDASGEA 40 VSETLQFKAQ 50 DLLRAVPRSR 60 AEMYDDVHSD 70 GRYSLSGSVA 80 HSRDAGREGL 90 RSDVFPGPSF 100 RSSNPSISDD 110 SYFRKECGRD 120 LEFSHSDSRD 130 QVIGHRKLGH 140 FRSQDWKFAL 150 RGSWEQDFGH 160 PVSQESSWSQ 170 EYSFGPSAVL 180 GDFGSSRLIE 190 KECLEKESRD 200 YDVDHPGEAD 210 SVLRGGSQVQ 220 ARGRALNIVD 230 QEGSLLGKGE 240 TQGLLTAKGG 250 VGKLVTLRNV 260 STKKIPTVNR 270 ITPKTQGTNQ 280 IQKNTPSPDV 290 TLGTNPGTED 300 IQFPIQKIPL 310 GLDLKNLRLP 320 RRKMSFDIID 330 KSDVFSRFGI 340 EIIKWAGFHT 350 IKDDIKFSQL 360 FQTLFELETE 370 TCAKMLASFK 380 CSLKPEHRDF 390 CFFTIKFLKH 400 SALKTPRVDN 410 EFLNMLLDKG 420 AVKTKNCFFE 430 IIKPFDKYIM 440 RLQDRLLKSV 450 TPLLMACNAY 460 ELSVKMKTLS 470 NPLDLALALE 480 TTNSLCRKSL 490 ALLGQTFSLA 500 SSFRQEKILE 510 AVGLQDIAPS 520 PAAFPNFEDS 530 TLFGREYIDH 540 LKAWLVSSGC 550 PLQVKKAEPE 560 PMREEEKMIP 570 PTKPEIQAKA 580 PSSLSDAVPQ 590 RADHRVVGTI 600 DQLVKRVIEG 610 SLSPKERTLL 620 KEDPAYWFLS 630 DENSLEYKYY 640 KLKLAEMQRM 650 SENLRGADQK 660 PTSADCAVRA 670 MLYSRAVRNL 680 KKKLLPWQRR 690 GLLRAQGLRG 700 WKARRATTGT 710 QTLLSSGTRL 720 KHHGRQAPGL 730 SQAKPSLPDR 740 NDAAKDCPPD 750 PVGPSPQDPS 760 LEASGPSPKP 770 AGVDISEAPQ 780 TSSPCPSADI 790 DMKTMETAEK 800 LARFVAQVGP 810 EIEQFSIENS 820 TDNPDLWFLH 830 DQNSSAFKFY 840 RKKVFELCPS 850 ICFTSSPHNL 860 HTGGGDTTGS 870 QESPVDLMEG 880 EAEFEDEPPP 890 REAELESPEV 900 MPEEEDEDDE 910 DGGEEAPAPG 920 GAGKSEGSTP 930 ADGLPGEAAE 940 DDLAGAPALS 950 QASSGTCFPR 960 KRISSKSLKV 970 GMIPAPKRVC 980 LIQEPKVHEP 990 VRIAYDRPRG 1000 RPMSKKKKPK 1010 DLDFAQQKLT 1020 DKNLGFQMLQ 1030 KMGWKEGHGL 1040 GSLGKGIREP 1050 VSVGTPSEGE 1060 GLGADGQEHK 1070 EDTFDVFRQR 1080 MMQMYRHKRA NK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006397 mRNA processing
Biological Process GO:0008380 RNA splicing

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.