Search Results
Overview
| Uniprot ID | Q8IX07 |
|---|---|
| Protein Name | Zinc finger protein ZFPM1 |
| Gene Name | ZFPM1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 281 | AAAATDEKPKETYPN |
Function
Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity)
Protein Sequence
10
MSRRKQSNPR
20
QIKRSLGDME
30
AREEVQLVGA
40
SHMEQKATAP
50
EAPSPPSADV
60
NSPPPLPPPT
70
SPGGPKELEG
80
QEPEPRPTEE
90
EPGSPWSGPD
100
ELEPVVQDGQ
110
RRIRARLSLA
120
TGLSWGPFHG
130
SVQTRASSPR
140
QAEPSPALTL
150
LLVDEACWLR
160
TLPQALTEAE
170
ANTEIHRKDD
180
ALWCRVTKPV
190
PAGGLLSVLL
200
TAEPHSTPGH
210
PVKKEPAEPT
220
CPAPAHDLQL
230
LPQQAGMASI
240
LATAVINKDV
250
FPCKDCGIWY
260
RSERNLQAHL
270
LYYCASRQGT
280
GSPAAAATDE
290
KPKETYPNER
300
VCPFPQCRKS
310
CPSASSLEIH
320
MRSHSGERPF
330
VCLICLSAFT
340
TKANCERHLK
350
VHTDTLSGVC
360
HSCGFISTTR
370
DILYSHLVTN
380
HMVCQPGSKG
390
EIYSPGAGHP
400
ATKLPPDSLG
410
SFQQQHTALQ
420
GPLASADLGL
430
APTPSPGLDR
440
KALAEATNGE
450
ARAEPLAQNG
460
GSSEPPAAPR
470
SIKVEAVEEP
480
EAAPILGPGE
490
PGPQAPSRTP
500
SPRSPAPARV
510
KAELSSPTPG
520
SSPVPGELGL
530
AGALFLPQYV
540
FGPDAAPPAS
550
EILAKMSELV
560
HSRLQQGAGA
570
GAGGAQTGLF
580
PGAPKGATCF
590
ECEITFSNVN
600
NYYVHKRLYC
610
SGRRAPEDAP
620
AARRPKAPPG
630
PARAPPGQPA
640
EPDAPRSSPG
650
PGAREEGAGG
660
AATPEDGAGG
670
RGSEGSQSPG
680
SSVDDAEDDP
690
SRTLCEACNI
700
RFSRHETYTV
710
HKRYYCASRH
720
DPPPRRPAAP
730
PGPPGPAAPP
740
APSPAAPVRT
750
RRRRKLYELH
760
AAGAPPPPPP
770
GHAPAPESPR
780
PGSGSGSGPG
790
LAPARSPGPA
800
ADGPIDLSKK
810
PRRPLPGAPA
820
PALADYHECT
830
ACRVSFHSLE
840
AYLAHKKYSC
850
PAAPPPGALG
860
LPAAACPYCP
870
PNGPVRGDLL
880
EHFRLAHGLL
890
LGAPLAGPGV
900
EARTPADRGP
910
SPAPAPAASP
920
QPGSRGPRDG
930
LGPEPQEPPP
940
GPPPSPAAAP
950
EAVPPPPAPP
960
SYSDKGVQTP
970
SKGTPAPLPN
980
GNHRYCRLCN
990
IKFSSLSTFI
1000
AHKKYYCSSH
AAEHVK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005667 | transcription regulator complex |
| Cellular Component | GO:0017053 | transcription repressor complex |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0060413 | atrial septum morphogenesis |
| Biological Process | GO:0003181 | atrioventricular valve morphogenesis |
| Biological Process | GO:0055008 | cardiac muscle tissue morphogenesis |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0035162 | embryonic hemopoiesis |
| Biological Process | GO:0030218 | erythrocyte differentiation |
| Biological Process | GO:0007507 | heart development |
| Biological Process | GO:0030219 | megakaryocyte differentiation |
| Biological Process | GO:0003192 | mitral valve formation |
| Biological Process | GO:0032713 | negative regulation of interleukin-4 production |
| Biological Process | GO:0060377 | negative regulation of mast cell differentiation |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0003151 | outflow tract morphogenesis |
| Biological Process | GO:0030220 | platelet formation |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0032729 | positive regulation of type II interferon production |
| Biological Process | GO:0010724 | regulation of definitive erythrocyte differentiation |
| Biological Process | GO:0002295 | T-helper cell lineage commitment |
| Biological Process | GO:0003195 | tricuspid valve formation |
| Biological Process | GO:0060412 | ventricular septum morphogenesis |
Reference
PMID: N/A