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Overview

Uniprot IDQ8IX12
Protein NameCell division cycle and apoptosis regulator protein 1
Gene NameCCAR1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
146 QQQTQPQKQRVFTGV
594 ETLSRGYKQQLVEKL
659 ALSSKGLKSQLIARL

Function

Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938)

Protein Sequence

10 MAQFGGQKNP 20 PWATQFTATA 30 VSQPAALGVQ 40 QPSLLGASPT 50 IYTQQTALAA 60 AGLTTQTPAN 70 YQLTQTAALQ 80 QQAAAAAAAL 90 QQQYSQPQQA 100 LYSVQQQLQQ 110 PQQTLLTQPA 120 VALPTSLSLS 130 TPQPTAQITV 140 SYPTPRSSQQ 150 QTQPQKQRVF 160 TGVVTKLHDT 170 FGFVDEDVFF 180 QLSAVKGKTP 190 QVGDRVLVEA 200 TYNPNMPFKW 210 NAQRIQTLPN 220 QNQSQTQPLL 230 KTPPAVLQPI 240 APQTTFGVQT 250 QPQPQSLLQA 260 QISAASITPL 270 LQTQPQPLLQ 280 QPQQKAGLLQ 290 PPVRIVSQPQ 300 PARRLDPPSR 310 FSGRNDRGDQ 320 VPNRKDDRSR 330 ERERERRRSR 340 ERSPQRKRSR 350 ERSPRRERER 360 SPRRVRRVVP 370 RYTVQFSKFS 380 LDCPSCDMME 390 LRRRYQNLYI 400 PSDFFDAQFT 410 WVDAFPLSRP 420 FQLGNYCNFY 430 VMHREVESLE 440 KNMAILDPPD 450 ADHLYSAKVM 460 LMASPSMEDL 470 YHKSCALAED 480 PQELRDGFQH 490 PARLVKFLVG 500 MKGKDEAMAI 510 GGHWSPSLDG 520 PDPEKDPSVL 530 IKTAIRCCKA 540 LTGIDLSVCT 550 QWYRFAEIRY 560 HRPEETHKGR 570 TVPAHVETVV 580 LFFPDVWHCL 590 PTRSEWETLS 600 RGYKQQLVEK 610 LQGERKEADG 620 EQDEEEKDDG 630 EAKEISTPTH 640 WSKLDPKTMK 650 VNDLRKELES 660 RALSSKGLKS 670 QLIARLTKQL 680 KVEEQKEEQK 690 ELEKSEKEED 700 EDDDRKSEDD 710 KEEEERKRQE 720 EIERQRRERR 730 YILPDEPAII 740 VHPNWAAKSG 750 KFDCSIMSLS 760 VLLDYRLEDN 770 KEHSFEVSLF 780 AELFNEMLQR 790 DFGVRIYKSL 800 LSLPEKEDKK 810 EKDKKSKKDE 820 RKDKKEERDD 830 ETDEPKPKRR 840 KSGDDKDKKE 850 DRDERKKEDK 860 RKDDSKDDDE 870 TEEDNNQDEY 880 DPMEAEEAED 890 EEDDRDEEEM 900 TKRDDKRDIN 910 RYCKERPSKD 920 KEKEKTQMIT 930 INRDLLMAFV 940 YFDQSHCGYL 950 LEKDLEEILY 960 TLGLHLSRAQ 970 VKKLLNKVVL 980 RESCFYRKLT 990 DTSKDEENHE 1000 ESESLQEDML 1010 GNRLLLPTPT 1020 VKQESKDVEE 1030 NVGLIVYNGA 1040 MVDVGSLLQK 1050 LEKSEKVRAE 1060 VEQKLQLLEE 1070 KTDEDEKTIL 1080 NLENSNKSLS 1090 GELREVKKDL 1100 SQLQENLKIS 1110 ENMNLQFENQ 1120 MNKTIRNLST 1130 VMDEIHTVLK 1140 KDNVKNEDKD 1150 QKSKENGASV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0005641 nuclear envelope lumen
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0048471 perinuclear region of cytoplasm
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0003713 transcription coactivator activity
Molecular Function GO:0003714 transcription corepressor activity
Biological Process GO:0006915 apoptotic process
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0030335 positive regulation of cell migration
Biological Process GO:0008284 positive regulation of cell population proliferation

Reference

[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.