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Overview

Uniprot IDQ8IX21
Protein NameSMC5-SMC6 complex localization factor protein 2
Gene NameSLF2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
100 LSSPKESKPKRVPPE
92 GTEQFERKLSSPKES
97 ERKLSSPKESKPKRV

Function

Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions (PubMed:25931565). Plays a role in SMC5-SMC6 complex recruitment for viral restriction. Forms a complex with SIMC1 and this complex is required to recruit SMC5-SMC6 complex to PML nuclear bodies and sites of viral replication (PubMed:36373674)

Protein Sequence

10 MTRRCMPARP 20 GFPSSPAPGS 30 SPPRCHLRPG 40 STAHAAAGKR 50 TESPGDRKQS 60 IIDFFKPASK 70 QDRHMLDSPQ 80 KSNIKYGGSR 90 LSITGTEQFE 100 RKLSSPKESK 110 PKRVPPEKSP 120 IIEAFMKGVK 130 EHHEDHGIHE 140 SRRPCLSLAS 150 KYLAKGTNIY 160 VPSSYHLPKE 170 MKSLKKKHRS 180 PERRKSLFIH 190 ENNEKNDRDR 200 GKTNADSKKQ 210 TTVAEADIFN 220 NSSRSLSSRS 230 SLSRHHPEES 240 PLGAKFQLSL 250 ASYCRERELK 260 RLRKEQMEQR 270 INSENSFSEA 280 SSLSLKSSIE 290 RKYKPRQEQR 300 KQNDIIPGKN 310 NLSNVENGHL 320 SRKRSSSDSW 330 EPTSAGSKQN 340 KFPEKRKRNS 350 VDSDLKSTRE 360 SMIPKARESF 370 LEKRPDGPHQ 380 KEKFIKHIAL 390 KTPGDVLRLE 400 DISKEPSDET 410 DGSSAGLAPS 420 NSGNSGHHST 430 RNSDQIQVAG 440 TKETKMQKPH 450 LPLSQEKSAI 460 KKASNLQKNK 470 TASSTTKEKE 480 TKLPLLSRVP 490 SAGSSLVPLN 500 AKNCALPVSK 510 KDKERSSSKE 520 CSGHSTESTK 530 HKEHKAKTNK 540 ADSNVSSGKI 550 SGGPLRSEYG 560 TPTKSPPAAL 570 EVVPCIPSPA 580 APSDKAPSEG 590 ESSGNSNAGS 600 SALKRKLRGD 610 FDSDEESLGY 620 NLDSDEEEET 630 LKSLEEIMAL 640 NFNQTPAATG 650 KPPALSKGLR 660 SQSSDYTGHV 670 HPGTYTNTLE 680 RLVKEMEDTQ 690 RLDELQKQLQ 700 EDIRQGRGIK 710 SPIRIGEEDS 720 TDDEDGLLEE 730 HKEFLKKFSV 740 TIDAIPDHHP 750 GEEIFNFLNS 760 GKIFNQYTLD 770 LRDSGFIGQS 780 AVEKLILKSG 790 KTDQIFLTTQ 800 GFLTSAYHYV 810 QCPVPVLKWL 820 FRMMSVHTDC 830 IVSVQILSTL 840 MEITIRNDTF 850 SDSPVWPWIP 860 SLSDVAAVFF 870 NMGIDFRSLF 880 PLENLQPDFN 890 EDYLVSETQT 900 TSRGKESEDS 910 SYKPIFSTLP 920 ETNILNVVKF 930 LGLCTSIHPE 940 GYQDREIMLL 950 ILMLFKMSLE 960 KQLKQIPLVD 970 FQSLLINLMK 980 NIRDWNTKVP 990 ELCLGINELS 1000 SHPHNLLWLV 1010 QLVPNWTSRG 1020 RQLRQCLSLV 1030 IISKLLDEKH 1040 EDVPNASNLQ 1050 VSVLHRYLVQ 1060 MKPSDLLKKM 1070 VLKKKAEQPD 1080 GIIDDSLHLE 1090 LEKQAYYLTY 1100 ILLHLVGEVS 1110 CSHSFSSGQR 1120 KHFVLLCGAL 1130 EKHVKCDIRE 1140 DARLFYRTKV 1150 KDLVARIHGK 1160 WQEIIQNCRP 1170 TQGQLHDFWV PDS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0000781 chromosome, telomeric region
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0016605 PML body
Cellular Component GO:0035861 site of double-strand break
Molecular Function GO:0044877 protein-containing complex binding
Molecular Function GO:0031625 ubiquitin protein ligase binding
Biological Process GO:0140588 chromatin looping
Biological Process GO:0006974 DNA damage response
Biological Process GO:0000724 double-strand break repair via homologous recombination
Biological Process GO:2000781 positive regulation of double-strand break repair
Biological Process GO:0034184 positive regulation of maintenance of mitotic sister chromatid cohesion
Biological Process GO:0031334 positive regulation of protein-containing complex assembly
Biological Process GO:1990166 protein localization to site of double-strand break
Biological Process GO:0016925 protein sumoylation
Biological Process GO:0032204 regulation of telomere maintenance

Reference

PMID: N/A