Overview
| Uniprot ID | Q8IX90 |
|---|
| Protein Name | Spindle and kinetochore-associated protein 3 |
|---|
| Gene Name | SKA3 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 399 |
PPSKRFLKHGQNIRD |
Function
Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:19289083, PubMed:19360002, PubMed:23085020). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083, PubMed:19360002). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:19289083). In the complex, it mediates the microtubule-stimulated oligomerization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020)
Protein Sequence
10
MDPIRSFCGK
20
LRSLASTLDC
30
ETARLQRALD
40
GEESDFEDYP
50
MRILYDLHSE
60
VQTLKDDVNI
70
LLDKARLENQ
80
EGIDFIKATK
90
VLMEKNSMDI
100
MKIREYFQKY
110
GYSPRVKKNS
120
VHEQEAINSD
130
PELSNCENFQ
140
KTDVKDDLSD
150
PPVASSCISE
160
KSPRSPQLSD
170
FGLERYIVSQ
180
VLPNPPQAVN
190
NYKEEPVIVT
200
PPTKQSLVKV
210
LKTPKCALKM
220
DDFECVTPKL
230
EHFGISEYTM
240
CLNEDYTMGL
250
KNARNNKSEE
260
AIDTESRLND
270
NVFATPSPII
280
QQLEKSDAEY
290
TNSPLVPTFC
300
TPGLKIPSTK
310
NSIALVSTNY
320
PLSKTNSSSN
330
DLEVEDRTSL
340
VLNSDTCFEN
350
LTDPSSPTIS
360
SYENLLRTPT
370
PPEVTKIPED
380
ILQLLSKYNS
390
NLATPIAIKA
400
VPPSKRFLKH
410
GQNIRDVSNK
EN
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005813 |
centrosome |
| Cellular Component |
GO:0000776 |
kinetochore |
| Cellular Component |
GO:0072687 |
meiotic spindle |
| Cellular Component |
GO:0072686 |
mitotic spindle |
| Cellular Component |
GO:0000940 |
outer kinetochore |
| Cellular Component |
GO:0170027 |
SKA complex |
| Cellular Component |
GO:0005876 |
spindle microtubule |
| Molecular Function |
GO:0008017 |
microtubule binding |
| Biological Process |
GO:0051315 |
attachment of mitotic spindle microtubules to kinetochore |
| Biological Process |
GO:0051301 |
cell division |
| Biological Process |
GO:0007059 |
chromosome segregation |
| Biological Process |
GO:0051296 |
establishment of meiotic spindle orientation |
| Biological Process |
GO:0051310 |
metaphase chromosome alignment |
| Biological Process |
GO:0000278 |
mitotic cell cycle |
| Biological Process |
GO:0007080 |
mitotic metaphase chromosome alignment |
| Biological Process |
GO:0000070 |
mitotic sister chromatid segregation |
| Biological Process |
GO:0140499 |
negative regulation of mitotic spindle assembly checkpoint signaling |
| Biological Process |
GO:0031110 |
regulation of microtubule polymerization or depolymerization |
| Biological Process |
GO:0007056 |
spindle assembly involved in female meiosis |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.