Search Results

Overview

Uniprot IDQ8IXK0
Protein NamePolyhomeotic-like protein 2
Gene NamePHC2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
598 SLLVGNLKKKYAQGF
600 LVGNLKKKYAQGFLP
655 VDFAYKFKRSKRFCS
675 RYNVGCTKRVGLFHS
689 SDRSKLQKAGAATHN
702 HNRRRASKASLPPLT
710 ASLPPLTKDTKKQPT

Function

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility

Protein Sequence

10 MENELPVPHT 20 SSSACATSST 30 SGASSSSGCN 40 NSSSGGSGRP 50 TGPQISVYSG 60 IPDRQTVQVI 70 QQALHRQPST 80 AAQYLQQMYA 90 AQQQHLMLQT 100 AALQQQHLSS 110 AQLQSLAAVQ 120 QASLVSNRQG 130 STSGSNVSAQ 140 APAQSSSINL 150 AASPAAAQLL 160 NRAQSVNSAA 170 ASGIAQQAVL 180 LGNTSSPALT 190 ASQAQMYLRA 200 QMLIFTPTAT 210 VATVQPELGT 220 GSPARPPTPA 230 QVQNLTLRTQ 240 QTPAAAASGP 250 TPTQPVLPSL 260 ALKPTPGGSQ 270 PLPTPAQSRN 280 TAQASPAGAK 290 PGIADSVMEP 300 HKKGDGNSSV 310 PGSMEGRAGL 320 SRTVPAVAAH 330 PLIAPAYAQL 340 QPHQLLPQPS 350 SKHLQPQFVI 360 QQQPQPQQQQ 370 PPPQQSRPVL 380 QAEPHPQLAS 390 VSPSVALQPS 400 SEAHAMPLGP 410 VTPALPLQCP 420 TANLHKPGGS 430 QQCHPPTPDT 440 GPQNGHPEGV 450 PHTPQRRFQH 460 TSAVILQLQP 470 ASPPQQCVPD 480 DWKEVAPGEK 490 SVPETRSGPS 500 PHQQAIVTAM 510 PGGLPVPTSP 520 NIQPSPAHET 530 GQGIVHALTD 540 LSSPGMTSGN 550 GNSASSIAGT 560 APQNGENKPP 570 QAIVKPQILT 580 HVIEGFVIQE 590 GAEPFPVGRS 600 SLLVGNLKKK 610 YAQGFLPEKL 620 PQQDHTTTTD 630 SEMEEPYLQE 640 SKEEGAPLKL 650 KCELCGRVDF 660 AYKFKRSKRF 670 CSMACAKRYN 680 VGCTKRVGLF 690 HSDRSKLQKA 700 GAATHNRRRA 710 SKASLPPLTK 720 DTKKQPTGTV 730 PLSVTAALQL 740 THSQEDSSRC 750 SDNSSYEEPL 760 SPISASSSTS 770 RRRQGQRDLE 780 LPDMHMRDLV 790 GMGHHFLPSE 800 PTKWNVEDVY 810 EFIRSLPGCQ 820 EIAEEFRAQE 830 IDGQALLLLK 840 EDHLMSAMNI 850 KLGPALKIYA RISMLKDS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0000792 heterochromatin
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0031519 PcG protein complex
Cellular Component GO:0035102 PRC1 complex
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0042393 histone binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0031507 heterochromatin formation
Biological Process GO:0045892 negative regulation of DNA-templated transcription

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[6] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.