Search Results
Overview
| Uniprot ID | Q8IXS2 |
|---|---|
| Protein Name | Dynein regulatory complex subunit 2 |
| Gene Name | DRC2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 208 | KNMNLEEKHFLRLHL |
Function
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules (PubMed:24094744)
Protein Sequence
10
MPKKEKMAKT
20
PLSDEKQLLL
30
FQQKLLAEEE
40
MAKKKERLLS
50
QFLKDKLAKE
60
EHNSALNLNK
70
INTQWRTVLR
80
EVKTRELHKD
90
IEILSQTFER
100
VVDCKDNVIK
110
SLAKDLSEAE
120
EQYAHALRSH
130
LHNVDQLLAL
140
QRHRLSLLEE
150
SYNMELEALT
160
KEFETERKTI
170
IDQHEKEIHY
180
LQDIFMAMEQ
190
NYIDSEYESK
200
LEFQSMWNDL
210
KNMNLEEKHF
220
LRLHLENRVE
230
DLWRKFQDVL
240
KNYTDATEDR
250
KAAFETLQVK
260
DEKSSKEIEV
270
QMKKIQKLQD
280
AITISKGKIM
290
IHSRESEDEN
300
RYIRNDKELV
310
LVQLRKLKAQ
320
RTQARAASQK
330
NLVRLTLESN
340
ATLKALRKIV
350
DKGEKILKLA
360
EICRKFETEE
370
EKVLPFYSSV
380
LTPKEQEGIQ
390
KNNLEELTEE
400
LTKVMVDYIG
410
MENFWKRYNK
420
VKLEQLSLQH
430
RRAQLLDING
440
KLREMLKQYL
450
DGISVSDEVL
460
SQLNPLFIVN
470
YQSNLLQPLS
480
IRIAHPGDKQ
HPTT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005858 | axonemal dynein complex |
| Cellular Component | GO:0005930 | axoneme |
| Cellular Component | GO:0036064 | ciliary basal body |
| Cellular Component | GO:0031514 | motile cilium |
| Biological Process | GO:0070286 | axonemal dynein complex assembly |
| Biological Process | GO:0060271 | cilium assembly |
| Biological Process | GO:0003341 | cilium movement |
| Biological Process | GO:0060285 | cilium-dependent cell motility |
| Biological Process | GO:0030317 | flagellated sperm motility |
| Biological Process | GO:0003352 | regulation of cilium movement |
Reference
[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.