Search Results
Overview
| Uniprot ID | Q8IY42 |
|---|---|
| Protein Name | PDCD10 and GCKIII kinases-associated protein 1 |
| Gene Name | PGCKA1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 40 | LDEDDTDKLKGKWSS |
Function
Acts as a tumor suppressor (PubMed:36882524, PubMed:38517886). Acts as a tumor suppressor for colorectal cancer cell proliferation by targeting KEAP1/USP17/ELK1/CDK6 axis (PubMed:36882524)
Protein Sequence
10
MGCRCCKIIQ
20
SYLFDPVQVP
30
SPGYVNEVNS
40
CKLDEDDTDK
50
LKGKWSSEVL
60
VQKNDPQRQG
70
SKKTESSSRT
80
ADPWEPCWPH
90
QGPLPQGDAG
100
GEHHACGVNG
110
IGPAATPQPT
120
GNSSPTQDDR
130
GSWASTANTV
140
PPTQPFLEGG
150
GTRKQDCVLL
160
ASEGTQVMRN
170
GDSRAPSEAE
180
SFALEVQDHV
190
FQIPAPDYLQ
200
HWGPAGDNVD
210
HNEKDCVFKN
220
HTEDESLEGI
230
QPPVGEHGLN
240
TPFSVRRSWD
250
SLNEDVETEV
260
LSICFNEKGP
270
VHAMPVVDSG
280
NRQEDTHGSD
290
GDGDGEIVDE
300
DAAVAEALAA
310
LEAATAGEDL
DETD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0071944 | cell periphery |
| Cellular Component | GO:0005886 | plasma membrane |
| Biological Process | GO:0051726 | regulation of cell cycle |
Reference
[1] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.