Search Results

Overview

Uniprot ID	Q8IY47
Protein Name	Kelch repeat and BTB domain-containing protein 2
Gene Name	KBTBD2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
339	TNHSKTSKLQTAFRT

Function

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of the insulin signaling pathway, modulating insulin sensitivity by limiting PIK3R1/p85alpha abundance in adipocytes. Targets PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase (PI3K), for 'Lys-48'-linked polyubiquitination and proteasome-mediated degradation

Protein Sequence

10 MSTQDERQIN 20 TEYAVSLLEQ 30 LKLFYEQQLF 40 TDIVLIVEGT 50 EFPCHKMVLA 60 TCSSYFRAMF 70 MSGLSESKQT 80 HVHLRNVDAA 90 TLQIIITYAY 100 TGNLAMNDST 110 VEQLYETACF 120 LQVEDVLQRC 130 REYLIKKINA 140 ENCVRLLSFA 150 DLFSCEELKQ 160 SAKRMVEHKF 170 TAVYHQDAFM 180 QLSHDLLIDI 190 LSSDNLNVEK 200 EETVREAAML 210 WLEYNTESRS 220 QYLSSVLSQI 230 RIDALSEVTQ 240 RAWFQGLPPN 250 DKSVVVQGLY 260 KSMPKFFKPR 270 LGMTKEEMMI 280 FIEASSENPC 290 SLYSSVCYSP 300 QAEKVYKLCS 310 PPADLHKVGT 320 VVTPDNDIYI 330 AGGQVPLKNT 340 KTNHSKTSKL 350 QTAFRTVNCF 360 YWFDAQQNTW 370 FPKTPMLFVR 380 IKPSLVCCEG 390 YIYAIGGDSV 400 GGELNRRTVE 410 RYDTEKDEWT 420 MVSPLPCAWQ 430 WSAAVVVHDC 440 IYVMTLNLMY 450 CYFPRSDSWV 460 EMAMRQTSRS 470 FASAAAFGDK 480 IFYIGGLHIA 490 TNSGIRLPSG 500 TVDGSSVTVE 510 IYDVNKNEWK 520 MAANIPAKRY 530 SDPCVRAVVI 540 SNSLCVFMRE 550 THLNERAKYV 560 TYQYDLELDR 570 WSLRQHISER 580 VLWDLGRDFR 590 CTVGKLYPSC 600 LEESPWKPPT 610 YLFSTDGTEE 620 FELDGEMVAL PPV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0031463	Cul3-RING ubiquitin ligase complex
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:1990756	ubiquitin-like ligase-substrate adaptor activity
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process	GO:0070936	protein K48-linked ubiquitination
Biological Process	GO:0000209	protein polyubiquitination
Biological Process	GO:1900076	regulation of cellular response to insulin stimulus

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.