Search Results

Overview

Uniprot IDQ8IY81
Protein Namepre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3
Gene NameFTSJ3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
14 VGKSRRDKFYHLAKE
20 DKFYHLAKETGYRSR
233 TVTELVTKKKPKAEG
234 VTELVTKKKPKAEGY
235 TELVTKKKPKAEGYA
237 LVTKKKPKAEGYAEG
384 AQEVAELKRKKKKLL
567 KGRQQQQKQQLPQTP
678 GAVIASSKKAKRDLI
679 AVIASSKKAKRDLID
740 EINARPIKKVAEAKA
763 RLEQTRKKAEAVVNT
804 HVTYVVAKKGVGRKV
805 VTYVVAKKGVGRKVR
822 AGVRGHFKVVDSRMK

Function

RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation

Protein Sequence

10 MGKKGKVGKS 20 RRDKFYHLAK 30 ETGYRSRSAF 40 KLIQLNRRFQ 50 FLQKARALLD 60 LCAAPGGWLQ 70 VAAKFMPVSS 80 LIVGVDLVPI 90 KPLPNVVTLQ 100 QDITTERCRQ 110 ALRKELKTWK 120 VDVVLNDGAP 130 NVGASWVHDA 140 YSQAHLTLMA 150 LRLACDFLAR 160 GGSFITKVFR 170 SRDYQPLLWI 180 FQQLFRRVQA 190 TKPQASRHES 200 AEIFVVCQGF 210 LAPDKVDSKF 220 FDPKFAFKEV 230 EVQAKTVTEL 240 VTKKKPKAEG 250 YAEGDLTLYH 260 RTSVTDFLRA 270 ANPVDFLSKA 280 SEIMVDDEEL 290 AQHPATTEDI 300 RVCCQDIRVL 310 GRKELRSLLN 320 WRTKLRRYVA 330 KKLKEQAKAL 340 DISLSSGEED 350 EGDEEDSTAG 360 TTKQPSKEEE 370 EEEEEEQLNQ 380 TLAEMKAQEV 390 AELKRKKKKL 400 LREQRKQRER 410 VELKMDLPGV 420 SIADEGETGM 430 FSLSTIRGHQ 440 LLEEVTQGDM 450 SAADTFLSDL 460 PRDDIYVSDV 470 EDDGDDTSLD 480 SDLDPEELAG 490 VRGHQGLRDQ 500 KRMRLTEVQD 510 DKEEEEEENP 520 LLVPLEEKAV 530 LQEEQANLWF 540 SKGSFAGIED 550 DADEALEISQ 560 AQLLFENRRK 570 GRQQQQKQQL 580 PQTPPSCLKT 590 EIMSPLYQDE 600 APKGTEASSG 610 TEAATGLEGE 620 EKDGISDSDS 630 STSSEEEESW 640 EPLRGKKRSR 650 GPKSDDDGFE 660 IVPIEDPAKH 670 RILDPEGLAL 680 GAVIASSKKA 690 KRDLIDNSFN 700 RYTFNEDEGE 710 LPEWFVQEEK 720 QHRIRQLPVG 730 KKEVEHYRKR 740 WREINARPIK 750 KVAEAKARKK 760 RRMLKRLEQT 770 RKKAEAVVNT 780 VDISEREKVA 790 QLRSLYKKAG 800 LGKEKRHVTY 810 VVAKKGVGRK 820 VRRPAGVRGH 830 FKVVDSRMKK 840 DQRAQQRKEQ KKKHKRK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0030687 preribosome, large subunit precursor
Cellular Component GO:0030688 preribosome, small subunit precursor
Molecular Function GO:0062105 RNA 2'-O-methyltransferase activity
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0016435 rRNA (guanine) methyltransferase activity
Molecular Function GO:0008650 rRNA (uridine-2'-O-)-methyltransferase activity
Biological Process GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Process GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Process GO:0001510 RNA methylation
Biological Process GO:0031167 rRNA methylation

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.