Search Results

Overview

Uniprot IDQ8IY92
Protein NameStructure-specific endonuclease subunit SLX4
Gene NameSLX4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1093 RSILTLSKEPGHQKG

Function

Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks

Protein Sequence

10 MKLSVNEAQL 20 GFYLGSLSHL 30 SACPGIDPRS 40 SEDQPESLKT 50 GQMMDESDED 60 FKELCASFFQ 70 RVKKHGIKEV 80 SGERKTQKAA 90 SNGTQIRSKL 100 KRTKQTATKT 110 KTLQGPAEKK 120 PPSGSQAPRT 130 KKQRVTKWQA 140 SEPAHSVNGE 150 GGVLASAPDP 160 PVLRETAQNT 170 QTGNQQEPSP 180 NLSREKTREN 190 VPNSDSQPPP 200 SCLTTAVPSP 210 SKPRTAQLVL 220 QRMQQFKRAD 230 PERLRHASEE 240 CSLEAAREEN 250 VPKDPQEEMM 260 AGNVYGLGPP 270 APESDAAVAL 280 TLQQEFARVG 290 ASAHDDSLEE 300 KGLFFCQICQ 310 KNLSAMNVTR 320 REQHVNRCLD 330 EAEKTLRPSV 340 PQIPECPICG 350 KPFLTLKSRT 360 SHLKQCAVKM 370 EVGPQLLLQA 380 VRLQTAQPEG 390 SSSPPMFSFS 400 DHSRGLKRRG 410 PTSKKEPRKR 420 RKVDEAPSED 430 LLVAMALSRS 440 EMEPGAAVPA 450 LRLESAFSER 460 IRPEAENKSR 470 KKKPPVSPPL 480 LLVQDSETTG 490 RQIEDRVALL 500 LSEEVELSST 510 PPLPASRILK 520 EGWERAGQCP 530 PPPERKQSFL 540 WEGSALTGAW 550 AMEDFYTARL 560 VPPLVPQRPA 570 QGLMQEPVPP 580 LVPPEHSELS 590 ERRSPALHGT 600 PTAGCGSRGP 610 SPSASQREHQ 620 ALQDLVDLAR 630 EGLSASPWPG 640 SGGLAGSEGT 650 AGLDVVPGGL 660 PLTGFVVPSQ 670 DKHPDRGGRT 680 LLSLGLLVAD 690 FGAMVNNPHL 700 SDVQFQTDSG 710 EVLYAHKFVL 720 YARCPLLIQY 730 VNNEGFSAVE 740 DGVLTQRVLL 750 GDVSTEAART 760 FLHYLYTADT 770 GLPPGLSSEL 780 SSLAHRFGVS 790 ELVHLCEQVP 800 IATDSEGKPW 810 EEKEAENCES 820 RAENFQELLR 830 SMWADEEEEA 840 ETLLKSKDHE 850 EDQENVNEAE 860 MEEIYEFAAT 870 QRKLLQEERA 880 AGAGEDADWL 890 EGGSPVSGQL 900 LAGVQVQKQW 910 DKVEEMEPLE 920 PGRDEAATTW 930 EKMGQCALPP 940 PQGQHSGARG 950 AEAPEQEAPE 960 EALGHSSCSS 970 PSRDCQAERK 980 EGSLPHSDDA 990 GDYEQLFSST 1000 QGEISEPSQI 1010 TSEPEEQSGA 1020 VRERGLEVSH 1030 RLAPWQASPP 1040 HPCRFLLGPP 1050 QGGSPRGSHH 1060 TSGSSLSTPR 1070 SRGGTSQVGS 1080 PTLLSPAVPS 1090 KQKRDRSILT 1100 LSKEPGHQKG 1110 KERRSVLECR 1120 NKGVLMFPEK 1130 SPSIDLTQSN 1140 PDHSSSRSQK 1150 SSSKLNEEDE 1160 VILLLDSDEE 1170 LELEQTKMKS 1180 ISSDPLEEKK 1190 ALEISPRSCE 1200 LFSIIDVDAD 1210 QEPSQSPPRS 1220 EAVLQQEDEG 1230 ALPENRGSLG 1240 RRGAPWLFCD 1250 RESSPSEAST 1260 TDTSWLVPAT 1270 PLASRSRDCS 1280 SQTQISSLRS 1290 GLAVQAVTQH 1300 TPRASVGNRE 1310 GNEVAQKFSV 1320 IRPQTPPPQT 1330 PSSCLTPVSP 1340 GTSDGRRQGH 1350 RSPSRPHPGG 1360 HPHSSPLAPH 1370 PISGDRAHFS 1380 RRFLKHSPPG 1390 PSFLNQTPAG 1400 EVVEVGDSDD 1410 EQEVASHQAN 1420 RSPPLDSDPP 1430 IPIDDCCWHM 1440 EPLSPIPIDH 1450 WNLERTGPLS 1460 TSSPSRRMNE 1470 AADSRDCRSP 1480 GLLDTTPIRG 1490 SCTTQRKLQE 1500 KSSGAGSLGN 1510 SRPSFLNSAL 1520 WDVWDGEEQR 1530 PPETPPPAQM 1540 PSAGGAQKPE 1550 GLETPKGANR 1560 KKNLPPKVPI 1570 TPMPQYSIME 1580 TPVLKKELDR 1590 FGVRPLPKRQ 1600 MVLKLKEIFQ 1610 YTHQTLDSDS 1620 EDESQSSQPL 1630 LQAPHCQTLA 1640 SQTYKPSRAG 1650 VHAQQEATTG 1660 PGAHRPKGPA 1670 KTKGPRHQRK 1680 HHESITPPSR 1690 SPTKEAPPGL 1700 NDDAQIPASQ 1710 ESVATSVDGS 1720 DSSLSSQSSS 1730 SCEFGAAFES 1740 AGEEEGEGEV 1750 SASQAAVQAA 1760 DTDEALRCYI 1770 RSKPALYQKV 1780 LLYQPFELRE 1790 LQAELRQNGL 1800 RVSSRRLLDF 1810 LDTHCITFTT 1820 AATRREKLQG 1830 RRRQPRGKKK VERN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0000781 chromosome, telomeric region
Cellular Component GO:0000228 nuclear chromosome
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0033557 Slx1-Slx4 complex
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0008047 enzyme activator activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing
Biological Process GO:0006281 DNA repair
Biological Process GO:0006260 DNA replication
Biological Process GO:0000724 double-strand break repair via homologous recombination
Biological Process GO:1904357 negative regulation of telomere maintenance via telomere lengthening
Biological Process GO:0006289 nucleotide-excision repair
Biological Process GO:1904431 positive regulation of t-circle formation
Biological Process GO:0032206 positive regulation of telomere maintenance
Biological Process GO:0000712 resolution of meiotic recombination intermediates
Biological Process GO:0072429 response to intra-S DNA damage checkpoint signaling
Biological Process GO:0090656 t-circle formation
Biological Process GO:0061820 telomeric D-loop disassembly

Reference

PMID: N/A