Overview
| Uniprot ID | Q8IYM9 |
|---|
| Protein Name | E3 ubiquitin-protein ligase TRIM22 |
|---|
| Gene Name | TRIM22 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 382 |
ISSLNKRKSSGFAFD |
Function
Interferon-induced E3 ubiquitin ligase that plays important roles in innate and adaptive immunity (PubMed:25683609, PubMed:35777501). Restricts the replication of many viruses including HIV-1, encephalomyocarditis virus (EMCV), hepatitis B virus (HBV), hepatitis C virus (HCV) or Zika virus (ZIKV) (PubMed:25683609, PubMed:35777501, PubMed:36042495). Mechanistically, negatively regulates HCV replication by promoting ubiquitination and subsequent degradation of viral NS5A (PubMed:25683609). Also acts by promoting the degradation of Zika virus NS1 and NS3 proteins through proteasomal degradation (PubMed:36042495). Acts as a suppressor of basal HIV-1 LTR-driven transcription by preventing Sp1 binding to the HIV-1 promoter (PubMed:26683615). Also plays a role in antiviral immunity by co-regulating together with NT5C2 the RIGI/NF-kappa-B pathway by promoting 'Lys-63'-linked ubiquitination of RIGI, while NT5C2 is responsible for 'Lys-48'-linked ubiquitination of RIGI (PubMed:36159777). Participates in adaptive immunity by suppressing the amount of MHC class II protein in a negative feedback manner in order to limit the extent of MHC class II induction (PubMed:35777501)
Protein Sequence
10
MDFSVKVDIE
20
KEVTCPICLE
30
LLTEPLSLDC
40
GHSFCQACIT
50
AKIKESVIIS
60
RGESSCPVCQ
70
TRFQPGNLRP
80
NRHLANIVER
90
VKEVKMSPQE
100
GQKRDVCEHH
110
GKKLQIFCKE
120
DGKVICWVCE
130
LSQEHQGHQT
140
FRINEVVKEC
150
QEKLQVALQR
160
LIKEDQEAEK
170
LEDDIRQERT
180
AWKNYIQIER
190
QKILKGFNEM
200
RVILDNEEQR
210
ELQKLEEGEV
220
NVLDNLAAAT
230
DQLVQQRQDA
240
STLISDLQRR
250
LRGSSVEMLQ
260
DVIDVMKRSE
270
SWTLKKPKSV
280
SKKLKSVFRV
290
PDLSGMLQVL
300
KELTDVQYYW
310
VDVMLNPGSA
320
TSNVAISVDQ
330
RQVKTVRTCT
340
FKNSNPCDFS
350
AFGVFGCQYF
360
SSGKYYWEVD
370
VSGKIAWILG
380
VHSKISSLNK
390
RKSSGFAFDP
400
SVNYSKVYSR
410
YRPQYGYWVI
420
GLQNTCEYNA
430
FEDSSSSDPK
440
VLTLFMAVPP
450
CRIGVFLDYE
460
AGIVSFFNVT
470
NHGALIYKFS
480
GCRFSRPAYP
490
YFNPWNCLVP
MTVCPPSS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0015030 |
Cajal body |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0016604 |
nuclear body |
| Cellular Component |
GO:0016607 |
nuclear speck |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0019901 |
protein kinase binding |
| Molecular Function |
GO:0030674 |
protein-macromolecule adaptor activity |
| Molecular Function |
GO:0003713 |
transcription coactivator activity |
| Molecular Function |
GO:0003714 |
transcription corepressor activity |
| Molecular Function |
GO:0061630 |
ubiquitin protein ligase activity |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0051607 |
defense response to virus |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0006955 |
immune response |
| Biological Process |
GO:0045087 |
innate immune response |
| Biological Process |
GO:0010508 |
positive regulation of autophagy |
| Biological Process |
GO:0043123 |
positive regulation of canonical NF-kappaB signal transduction |
| Biological Process |
GO:0002230 |
positive regulation of defense response to virus by host |
| Biological Process |
GO:0070534 |
protein K63-linked ubiquitination |
| Biological Process |
GO:0006355 |
regulation of DNA-templated transcription |
| Biological Process |
GO:0010468 |
regulation of gene expression |
| Biological Process |
GO:0032880 |
regulation of protein localization |
| Biological Process |
GO:0009615 |
response to virus |
Reference
[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.