Search Results
Overview
| Uniprot ID | Q8IYS1 |
|---|---|
| Protein Name | Xaa-Arg dipeptidase |
| Gene Name | PM20D2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 281 | YFRAPSMKELQVLTK |
Function
Catalyzes the peptide bond hydrolysis in dipeptides having basic amino acids lysine, ornithine or arginine at C-terminus. Postulated to function in a metabolite repair mechanism by eliminating alternate dipeptide by-products formed during carnosine synthesis
Protein Sequence
10
MRPGGERPVE
20
GGACNGRSEL
30
ELLKLRSAEC
40
IDEAAERLGA
50
LSRAIWSQPE
60
LAYEEHHAHR
70
VLTHFFEREP
80
PAASWAVQPH
90
YQLPTAFRAE
100
WEPPEARAPS
110
ATPRPLHLGF
120
LCEYDALPGI
130
GHACGHNLIA
140
EVGAAAALGV
150
RGALEGLPRP
160
PPPVKVVVLG
170
TPAEEDGGGK
180
IDLIEAGAFT
190
NLDVVFMAHP
200
SQENAAYLPD
210
MAEHDVTVKY
220
YGKASHSASY
230
PWEGLNALDA
240
AVLAYNNLSV
250
FRQQMKPTWR
260
VHGIIKNGGV
270
KPNIIPSYSE
280
LIYYFRAPSM
290
KELQVLTKKA
300
EDCFRAAALA
310
SGCTVEIKGG
320
AHDYYNVLPN
330
KSLWKAYMEN
340
GRKLGIEFIS
350
EDTMLNGPSG
360
STDFGNVSFV
370
VPGIHPYFHI
380
GSNALNHTEQ
390
YTEAAGSQEA
400
QFYTLRTAKA
410
LAMTALDVIF
420
KPELLEGIRE
430
DFKLKLQEEQ
FVNAVE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0004180 | carboxypeptidase activity |
| Molecular Function | GO:0016805 | dipeptidase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Biological Process | GO:0006508 | proteolysis |
| Biological Process | GO:0051246 | regulation of protein metabolic process |
Reference
[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.