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Overview

Uniprot IDQ8IZ21
Protein NamePhosphatase and actin regulator 4
Gene NamePHACTR4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
36 PPTKRKSKFSGFGKI
677 ADKAAIRKELNEFKS

Function

Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity)

Protein Sequence

10 MEDPFEEADQ 20 PTTEPGMVLD 30 SVEAGDTTPP 40 TKRKSKFSGF 50 GKIFKPWKWR 60 KKKSSDKFKE 70 TSEVLERKIS 80 MRKPREELVK 90 RGVLLEDPEQ 100 GGEDPGKPSD 110 AMLKNGHTTP 120 IGNARSSSPV 130 QVEEEPVRLA 140 SLRKAIPEED 150 LKKRLGSTGS 160 QPNSEAESVP 170 ENVPKPPLLP 180 PKRPLSSSHE 190 ASEGQAKDAT 200 SSGGTARFII 210 STSITTAPAA 220 TTAATSLAKT 230 VNLSVTPSPA 240 PRTLPAAPAS 250 TNTTATPSLT 260 HMVPAKQPPI 270 PPPKPAHRNS 280 NPVIAELSQA 290 INSGTLLSKP 300 SPPLPPKRGI 310 PSTSVPTLES 320 AAAITTKTPS 330 DEREKSTCSM 340 GSELLPMISP 350 RSPSPPLPTH 360 IPPEPPRTPP 370 FPAKTFQVVP 380 EIEFPPSLDL 390 HQEIPQQEDQ 400 KKEVPKRILD 410 QNFGEPHIPS 420 RLPPLPLHIR 430 IQQALTSPLP 440 MTPILEGSHR 450 AHSLLFENSD 460 SFSEDSSTLG 470 RTRSLPITIE 480 MLKVPDDEEE 490 EEQTCPSTFS 500 EEMTPTSVIP 510 KLPQCLREEE 520 EKESDSDSEG 530 PIQYRDEEDE 540 DESYQSALAN 550 KVKRKDTLAM 560 KLNHRPSEPE 570 LNLNSWPCKS 580 KEEWNEIRHQ 590 IGNTLIRRLS 600 QRPTPEELEQ 610 RNILQPKNEA 620 DRQAEKREIK 630 RRLTRKLSQR 640 PTVAELLARK 650 ILRFNEYVEV 660 TDAQDYDRRA 670 DKPWTKLTPA 680 DKAAIRKELN 690 EFKSSEMEVH 700 EESKHFTRYH RP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0030027 lamellipodium
Molecular Function GO:0003779 actin binding
Molecular Function GO:0008157 protein phosphatase 1 binding
Molecular Function GO:0072542 protein phosphatase activator activity
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0061386 closure of optic fissure
Biological Process GO:0048484 enteric nervous system development
Biological Process GO:2001045 negative regulation of integrin-mediated signaling pathway
Biological Process GO:0001755 neural crest cell migration
Biological Process GO:0001843 neural tube closure
Biological Process GO:0043085 positive regulation of catalytic activity
Biological Process GO:0051726 regulation of cell cycle
Biological Process GO:0007266 Rho protein signal transduction

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.