Search Results
Overview
| Uniprot ID | Q8IZ40 |
|---|---|
| Protein Name | REST corepressor 2 |
| Gene Name | RCOR2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 241 | ARPGPGKKEVQVSQY |
| 7 | *MPSVMEKPSAGSGI |
Function
May act as a component of a corepressor complex that represses transcription
Protein Sequence
10
MPSVMEKPSA
20
GSGILSRSRA
30
KTVPNGGQPH
40
SEDDSSEEEH
50
SHDSMIRVGT
60
NYQAVIPECK
70
PESPARYSNK
80
ELKGMLVWSP
90
NHCVSDAKLD
100
KYIAMAKEKH
110
GYNIEQALGM
120
LLWHKHDVEK
130
SLADLANFTP
140
FPDEWTVEDK
150
VLFEQAFGFH
160
GKCFQRIQQM
170
LPDKLIPSLV
180
KYYYSWKKTR
190
SRTSVMDRQA
200
RRLGGRKDKE
210
DSDELEEGRG
220
GVSEGEPDPA
230
DPKREPLPSR
240
PLNARPGPGK
250
KEVQVSQYRH
260
HPLRTRRRPP
270
KGMYLSPEGL
280
TAVSGSPDLA
290
NLTLRGLDSQ
300
LISLKRQVQS
310
MKQTNSSLRQ
320
ALEGGIDPLR
330
PPEANTKFNS
340
RWTTDEQLLA
350
VQAIRRYGKD
360
FGAIAEVIGN
370
KTLTQVKTFF
380
VSYRRRFNLE
390
EVLQEWEAEQ
400
DGAPGAPVPM
410
EEARRGAPLP
420
APALEEDDEV
430
QITSVSTSVP
440
RSVPPAPPPP
450
PPPTSLSQPP
460
PLLRPPLPTA
470
PTLLRQPPPL
480
QQGRFLQPRL
490
APNQPPPPLI
500
RPALAAPRHS
510
ARPGPQPPPT
520
LIGTPLEPPA
PSL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000118 | histone deacetylase complex |
| Cellular Component | GO:0005667 | transcription regulator complex |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.