Search Results

Overview

Uniprot ID	Q8IZD2
Protein Name	Histone reader KMT2E
Gene Name	KMT2E
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1431	SSEQLSQKLPSVPTK
340	ESHIQKNKKILKSAK
644	ASKPTPAKVNRTKQR
801	TSPFLSEKRRRKEPT

Function

Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription (PubMed:23629655, PubMed:23798402, PubMed:24130829). Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3) (PubMed:23798402, PubMed:24130829). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation (By similarity). Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry (PubMed:14718661, PubMed:18573682, PubMed:19264965, PubMed:23629655). Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells (By similarity)

Protein Sequence

10 MSIVIPLGVD 20 TAETSYLEMA 30 AGSEPESVEA 40 SPVVVEKSNS 50 YPHQLYTSSS 60 HHSHSYIGLP 70 YADHNYGARP 80 PPTPPASPPP 90 SVLISKNEVG 100 IFTTPNFDET 110 SSATTISTSE 120 DGSYGTDVTR 130 CICGFTHDDG 140 YMICCDKCSV 150 WQHIDCMGID 160 RQHIPDTYLC 170 ERCQPRNLDK 180 ERAVLLQRRK 190 RENMSDGDTS 200 ATESGDEVPV 210 ELYTAFQHTP 220 TSITLTASRV 230 SKVNDKRRKK 240 SGEKEQHISK 250 CKKAFREGSR 260 KSSRVKGSAP 270 EIDPSSDGSN 280 FGWETKIKAW 290 MDRYEEANNN 300 QYSEGVQREA 310 QRIALRLGNG 320 NDKKEMNKSD 330 LNTNNLLFKP 340 PVESHIQKNK 350 KILKSAKDLP 360 PDALIIEYRG 370 KFMLREQFEA 380 NGYFFKRPYP 390 FVLFYSKFHG 400 LEMCVDARTF 410 GNEARFIRRS 420 CTPNAEVRHE 430 IQDGTIHLYI 440 YSIHSIPKGT 450 EITIAFDFDY 460 GNCKYKVDCA 470 CLKENPECPV 480 LKRSSESMEN 490 INSGYETRRK 500 KGKKDKDISK 510 EKDTQNQNIT 520 LDCEGTTNKM 530 KSPETKQRKL 540 SPLRLSVSNN 550 QEPDFIDDIE 560 EKTPISNEVE 570 MESEEQIAER 580 KRKMTREERK 590 MEAILQAFAR 600 LEKREKRREQ 610 ALERISTAKT 620 EVKTECKDTQ 630 IVSDAEVIQE 640 QAKEENASKP 650 TPAKVNRTKQ 660 RKSFSRSRTH 670 IGQQRRRHRT 680 VSMCSDIQPS 690 SPDIEVTSQQ 700 NDIENTVLTI 710 EPETETALAE 720 IITETEVPAL 730 NKCPTKYPKT 740 KKHLVNEWLS 750 EKNEKTGKPS 760 DGLSERPLRI 770 TTDPEVLATQ 780 LNSLPGLTYS 790 PHVYSTPKHY 800 IRFTSPFLSE 810 KRRRKEPTEN 820 ISGSCKKRWL 830 KQALEEENSA 840 ILHRFNSPCQ 850 ERSRSPAVNG 860 ENKSPLLLND 870 SCSLPDLTTP 880 LKKRRFYQLL 890 DSVYSETSTP 900 TPSPYATPTH 910 TDITPMDPSF 920 ATPPRIKSDD 930 ETCRNGYKPI 940 YSPVTPVTPG 950 TPGNTMHFEN 960 ISSPESSPEI 970 KRRTYSQEGY 980 DRSSTMLTLG 990 PFRNSNLTEL 1000 GLQEIKTIGY 1010 TSPRSRTEVN 1020 RQCPGEKEPV 1030 SDLQLGLDAV 1040 EPTALHKTLE 1050 TPAHDRAEPN 1060 SQLDSTHSGR 1070 GTMYSSWVKS 1080 PDRTGVNFSV 1090 NSNLRDLTPS 1100 HQLEVGGGFR 1110 ISESKCLMQD 1120 DTRGMFMETT 1130 VFCTSEDGLV 1140 SGFGRTVNDN 1150 LIDGNCTPQN 1160 PPQKKKVSLL 1170 EYRKRQREAR 1180 KSGSKTENFP 1190 LISVSPHASG 1200 SLSNNGDGCA 1210 SSNDNGEQVD 1220 HTASLPLPTP 1230 ATVYNATSEE 1240 TSNNCPVKDA 1250 TASEKNEPEV 1260 QWTASTSVEQ 1270 VRERSYQRAL 1280 LLSDHRKDKD 1290 SGGESPCVSC 1300 SPSHVQSSPS 1310 SHSNHIPQLQ 1320 AKGPVPSFSE 1330 LMEDPDPENP 1340 EPTTTNECPS 1350 PDTSQNTCKS 1360 PPKMSKPGSP 1370 GSVIPAQAHG 1380 KIFTKPDPQW 1390 DSTVSASEAE 1400 NGVHLKTELQ 1410 QKQLSNNNQA 1420 LSKNHPPQTH 1430 VRNSSEQLSQ 1440 KLPSVPTKLH 1450 CPPSPHLENP 1460 PKSSTPHTPV 1470 QHGYLSPKPP 1480 SQQLGSPYRP 1490 HHSQSPQVGT 1500 PQREPQRNFY 1510 PAAQNLPANT 1520 QQATSGTLFT 1530 QTPSGQSSAT 1540 YSQFNQQSLN 1550 STAPPPPPPP 1560 PPSSSYYQNQ 1570 QPSANFQNYN 1580 QLKGSLSQQT 1590 VFTSGPNQAL 1600 PGTTSQQTVP 1610 GHHVTPGHFL 1620 PSQNPTIHHQ 1630 TAAAVVPPPP 1640 PPPPAPGPHL 1650 VQQPNSHQQH 1660 SVAHVVGPVH 1670 AVTPGSHIHS 1680 QTAGHHLPPP 1690 PPPPGPAPHH 1700 HPPPHPSTGL 1710 QGLQAQHQHV 1720 VNSAPPPPPP 1730 PPPSSVLASG 1740 HHTTSAQALH 1750 HPPHQGPPLF 1760 PSSAHPTVPP 1770 YPSQATHHTT 1780 LGPGPQHQPS 1790 GTGPHCPLPV 1800 TGPHLQPQGP 1810 NSIPTPTASG 1820 FCPHPGSVAL 1830 PHGVQGPQQA 1840 SPVPGQIPIH 1850 RAQVPPTFQN NYHGSGWH

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0000785	chromatin
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0000791	euchromatin
Cellular Component	GO:0016607	nuclear speck
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0032991	protein-containing complex
Cellular Component	GO:0070210	Rpd3L-Expanded complex
Cellular Component	GO:0034967	Set3 complex
Molecular Function	GO:0019899	enzyme binding
Molecular Function	GO:0140002	histone H3K4me3 reader activity
Molecular Function	GO:0003713	transcription coactivator activity
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0040029	epigenetic regulation of gene expression
Biological Process	GO:0030218	erythrocyte differentiation
Biological Process	GO:0042119	neutrophil activation
Biological Process	GO:0002446	neutrophil mediated immunity
Biological Process	GO:0045893	positive regulation of DNA-templated transcription
Biological Process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle
Biological Process	GO:0006355	regulation of DNA-templated transcription

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.