Search Results

Overview

Uniprot IDQ8IZF6
Protein NameAdhesion G protein-coupled receptor G4
Gene NameADGRG4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
132 IWDGVKGKLELFLNK
139 KLELFLNKERILEVT

Function

Orphan adhesion G protein-coupled receptor (aGPCR) (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (By similarity). ADGRG4 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity (PubMed:35418677). May be act as sensor of mechanical forces (PubMed:37863265)

Protein Sequence

10 MKEHIIYQKL 20 YGLILMSSFI 30 FLSDTLSLKG 40 KKLDFFGRGD 50 TYVSLIDTIP 60 ELSRFTACID 70 LVFMDDNSRY 80 WMAFSYITNN 90 ALLGREDIDL 100 GLAGDHQQLI 110 LYRLGKTFSI 120 RHHLASFQWH 130 TICLIWDGVK 140 GKLELFLNKE 150 RILEVTDQPH 160 NLTPHGTLFL 170 GHFLKNESSE 180 VKSMMRSFPG 190 SLYYFQLWDH 200 ILENEEFMKC 210 LDGNIVSWEE 220 DVWLVNKIIP 230 TVDRTLRCFV 240 PENMTIQEKS 250 TTVSQQIDMT 260 TPSQITGVKP 270 QNTAHSSTLL 280 SQSIPIFATD 290 YTTISYSNTT 300 SPPLETMTAQ 310 KILKTLVDET 320 ATFAVDVLST 330 SSAISLPTQS 340 ISIDNTTNSM 350 KKTKSPSSES 360 TKTTKMVEAM 370 ATEIFQPPTP 380 SNFLSTSRFT 390 KNSVVSTTSA 400 IKSQSAVTKT 410 TSLFSTIEST 420 SMSTTPCLKQ 430 KSTNTGALPI 440 STAGQEFIES 450 TAAGTVPWFT 460 VEKTSPASTH 470 VGTASSFPPE 480 PVLISTAAPV 490 DSVFPRNQTA 500 FPLATTDMKI 510 AFTVHSLTLP 520 TRLIETTPAP 530 RTAETELTST 540 NFQDVSLPRV 550 EDAMSTSMSK 560 ETSSKTFSFL 570 TSFSFTGTES 580 VQTVIDAEAT 590 RTALTPEITL 600 ASTVAETMLS 610 STITGRVYTQ 620 NTPTADGHLL 630 TLMSTRSAST 640 SKAPESGPTS 650 TTDEAAHLFS 660 SNETIWTSRP 670 DQALLASMNT 680 TTILTFVPNE 690 NFTSAFHENT 700 TYTEYLSATT 710 NITPLKASPE 720 GKGTTANDAT 730 TARYTTAVSK 740 LTSPWFANFS 750 IVSGTTSITN 760 MPEFKLTTLL 770 LKTIPMSTKP 780 ANELPLTPRE 790 TVVPSVDIIS 800 TLACIQPNFS 810 TEESASETTQ 820 TEINGAIVFG 830 GTTTPVPKSA 840 TTQRLNATVT 850 RKEATSHYLM 860 RKSTIAAVAE 870 VSPFSTMLEV 880 TDESAQRVTA 890 SVTVSSFPDI 900 EKLSTPLDNK 910 TATTEVRESW 920 LLTKLVKTTP 930 RSSYNEMTEM 940 FNFNHTYVAH 950 WTSETSEGIS 960 AGSPTSGSTH 970 IFGEPLGAST 980 TRISETSFST 990 TPTDRTATSL 1000 SDGILPPQPT 1010 AAHSSATPVP 1020 VTHMFSLPVN 1030 GSSVVAEETE 1040 VTMSEPSTLA 1050 RAFSTSVLSD 1060 VSNLSSTTMT 1070 TALVPPLDQT 1080 ASTTIVIVPT 1090 HGDLIRTTSE 1100 ATVISVRKTS 1110 MAVPSLTETP 1120 FHSLRLSTPV 1130 TAKAETTLFS 1140 TSVDTVTPST 1150 HTLVCSKPPP 1160 DNIPPASSTH 1170 VISTTSTPEA 1180 TQPISQVEET 1190 STYALSFPYT 1200 FSGGGVVASL 1210 ATGTTETSVV 1220 DETTPSHISA 1230 NKLTTSVNSH 1240 ISSSATYRVH 1250 TPVSIQLVTS 1260 TSVLSSDKDQ 1270 MTISLGKTPR 1280 TMEVTEMSPS 1290 KNSFISYSRG 1300 TPSLEMTDTG 1310 FPETTKISSH 1320 QTHSPSEIPL 1330 GTPSDGNLAS 1340 SPTSGSTQIT 1350 PTLTSSNTVG 1360 VHIPEMSTSL 1370 GKTALPSQAL 1380 TITTFLCPEK 1390 ESTSALPAYT 1400 PRTVEMIVNS 1410 TYVTHSVSYG 1420 QDTSFVDTTT 1430 SSSTRISNPM 1440 DINTTFSHLH 1450 SLRTQPEVTS 1460 VASFISESTQ 1470 TFPESLSLST 1480 AGLYNDGFTV 1490 LSDRITTAFS 1500 VPNVPTMLPR 1510 ESSMATSTPI 1520 YQMSSLPVNV 1530 TAFTSKKVSD 1540 TPPIVITKSS 1550 KTMHPGCLKS 1560 PCTATSGPMS 1570 EMSSIPVNNS 1580 AFTPATVSSD 1590 TSTRVGLFST 1600 LLSSVTPRTT 1610 MTMQTSTLDV 1620 TPVIYAGATS 1630 KNKMVSSAFT 1640 TEMIEAPSRI 1650 TPTTFLSPTE 1660 PTLPFVKTVP 1670 TTIMAGIVTP 1680 FVGTTAFSPL 1690 SSKSTGAISS 1700 IPKTTFSPFL 1710 SATQQSSQAD 1720 EATTLGILSG 1730 ITNRSLSTVN 1740 SGTGVALTDT 1750 YSRITVPENM 1760 LSPTHADSLH 1770 TSFNIQVSPS 1780 LTSFKSASGP 1790 TKNVKTTTNC 1800 FSSNTRKMTS 1810 LLEKTSLTNY 1820 ATSLNTPVSY 1830 PPWTPSSATL 1840 PSLTSFVYSP 1850 HSTEAEISTP 1860 KTSPPPTSQM 1870 VEFPVLGTRM 1880 TSSNTQPLLM 1890 TSWNIPTAEG 1900 SQFPISTTIN 1910 VPTSNEMETE 1920 TLHLVPGPLS 1930 TFTASQTGLV 1940 SKDVMAMSSI 1950 PMSGILPNHG 1960 LSENPSLSTS 1970 LRAITSTLAD 1980 VKHTFEKMTT 1990 SVTPGTTLPS 2000 ILSGATSGSV 2010 ISKSPILTWL 2020 LSSLPSGSPP 2030 ATVSNAPHVM 2040 TSSTVEVSKS 2050 TFLTSDMISA 2060 HPFTNLTTLP 2070 SATMSTILTR 2080 TIPTPTLGGI 2090 TTGFPTSLPM 2100 SINVTDDIVY 2110 ISTHPEASSR 2120 TTITANPRTV 2130 SHPSSFSRKT 2140 MSPSTTDHTL 2150 SVGAMPLPSS 2160 TITSSWNRIP 2170 TASSPSTLII 2180 PKPTLDSLLN 2190 IMTTTSTVPG 2200 ASFPLISTGV 2210 TYPFTATVSS 2220 PISSFFETTW 2230 LDSTPSFLST 2240 EASTSPTATK 2250 STVSFYNVEM 2260 SFSVFVEEPR 2270 IPITSVINEF 2280 TENSLNSIFQ 2290 NSEFSLATLE 2300 TQIKSRDISE 2310 EEMVMDRAIL 2320 EQREGQEMAT 2330 ISYVPYSCVC 2340 QVIIKASSSL 2350 ASSELMRKIK 2360 SKIHGNFTHG 2370 NFTQDQLTLL 2380 VNCEHVAVKK 2390 LEPGNCKADE 2400 TASKYKGTYK 2410 WLLTNPTETA 2420 QTRCIKNEDG 2430 NATRFCSISI 2440 NTGKSQWEKP 2450 KFKQCKLLQE 2460 LPDKIVDLAN 2470 ITISDENAED 2480 VAEHILNLIN 2490 ESPALGKEET 2500 KIIVSKISDI 2510 SQCDEISMNL 2520 THVMLQIINV 2530 VLEKQNNSAS 2540 DLHEISNEIL 2550 RIIERTGHKM 2560 EFSGQIANLT 2570 VAGLALAVLR 2580 GDHTFDGMAF 2590 SIHSYEEGTD 2600 PEIFLGNVPV 2610 GGILASIYLP 2620 KSLTERIPLS 2630 NLQTILFNFF 2640 GQTSLFKTKN 2650 VTKALTTYVV 2660 SASISDDMFI 2670 QNLADPVVIT 2680 LQHIGGNQNY 2690 GQVHCAFWDF 2700 ENNNGLGGWN 2710 SSGCKVKETN 2720 VNYTICQCDH 2730 LTHFGVLMDL 2740 SRSTVDSVNE 2750 QILALITYTG 2760 CGISSIFLGV 2770 AVVTYIAFHK 2780 LRKDYPAKIL 2790 INLCTALLML 2800 NLVFLINSWL 2810 SSFQKVGVCI 2820 TAAVALHYFL 2830 LVSFTWMGLE 2840 AVHMYLALVK 2850 VFNIYIPNYI 2860 LKFCLVGWGI 2870 PAIMVAITVS 2880 VKKDLYGTLS 2890 PTTPFCWIKD 2900 DSIFYISVVA 2910 YFCLIFLMNL 2920 SMFCTVLVQL 2930 NSVKSQIQKT 2940 RRKMILHDLK 2950 GTMSLTFLLG 2960 LTWGFAFFAW 2970 GPMRNFFLYL 2980 FAIFNTLQGF 2990 FIFVFHCVMK 3000 ESVREQWQIH 3010 LCCGWLRLDN 3020 SSDGSSRCQI 3030 KVGYKQEGLK 3040 KIFEHKLLTP 3050 SLKSTATSST 3060 FKSLGSAQGT 3070 PSEISFPNDD 3080 FDKDPYCSSP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016020 membrane
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0004930 G protein-coupled receptor activity
Biological Process GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Process GO:0007166 cell surface receptor signaling pathway
Biological Process GO:0007186 G protein-coupled receptor signaling pathway

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.