Search Results
Overview
| Uniprot ID | Q8IZF6 |
|---|---|
| Protein Name | Adhesion G protein-coupled receptor G4 |
| Gene Name | ADGRG4 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 132 | IWDGVKGKLELFLNK |
| 139 | KLELFLNKERILEVT |
Function
Orphan adhesion G protein-coupled receptor (aGPCR) (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (By similarity). ADGRG4 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity (PubMed:35418677). May be act as sensor of mechanical forces (PubMed:37863265)
Protein Sequence
10
MKEHIIYQKL
20
YGLILMSSFI
30
FLSDTLSLKG
40
KKLDFFGRGD
50
TYVSLIDTIP
60
ELSRFTACID
70
LVFMDDNSRY
80
WMAFSYITNN
90
ALLGREDIDL
100
GLAGDHQQLI
110
LYRLGKTFSI
120
RHHLASFQWH
130
TICLIWDGVK
140
GKLELFLNKE
150
RILEVTDQPH
160
NLTPHGTLFL
170
GHFLKNESSE
180
VKSMMRSFPG
190
SLYYFQLWDH
200
ILENEEFMKC
210
LDGNIVSWEE
220
DVWLVNKIIP
230
TVDRTLRCFV
240
PENMTIQEKS
250
TTVSQQIDMT
260
TPSQITGVKP
270
QNTAHSSTLL
280
SQSIPIFATD
290
YTTISYSNTT
300
SPPLETMTAQ
310
KILKTLVDET
320
ATFAVDVLST
330
SSAISLPTQS
340
ISIDNTTNSM
350
KKTKSPSSES
360
TKTTKMVEAM
370
ATEIFQPPTP
380
SNFLSTSRFT
390
KNSVVSTTSA
400
IKSQSAVTKT
410
TSLFSTIEST
420
SMSTTPCLKQ
430
KSTNTGALPI
440
STAGQEFIES
450
TAAGTVPWFT
460
VEKTSPASTH
470
VGTASSFPPE
480
PVLISTAAPV
490
DSVFPRNQTA
500
FPLATTDMKI
510
AFTVHSLTLP
520
TRLIETTPAP
530
RTAETELTST
540
NFQDVSLPRV
550
EDAMSTSMSK
560
ETSSKTFSFL
570
TSFSFTGTES
580
VQTVIDAEAT
590
RTALTPEITL
600
ASTVAETMLS
610
STITGRVYTQ
620
NTPTADGHLL
630
TLMSTRSAST
640
SKAPESGPTS
650
TTDEAAHLFS
660
SNETIWTSRP
670
DQALLASMNT
680
TTILTFVPNE
690
NFTSAFHENT
700
TYTEYLSATT
710
NITPLKASPE
720
GKGTTANDAT
730
TARYTTAVSK
740
LTSPWFANFS
750
IVSGTTSITN
760
MPEFKLTTLL
770
LKTIPMSTKP
780
ANELPLTPRE
790
TVVPSVDIIS
800
TLACIQPNFS
810
TEESASETTQ
820
TEINGAIVFG
830
GTTTPVPKSA
840
TTQRLNATVT
850
RKEATSHYLM
860
RKSTIAAVAE
870
VSPFSTMLEV
880
TDESAQRVTA
890
SVTVSSFPDI
900
EKLSTPLDNK
910
TATTEVRESW
920
LLTKLVKTTP
930
RSSYNEMTEM
940
FNFNHTYVAH
950
WTSETSEGIS
960
AGSPTSGSTH
970
IFGEPLGAST
980
TRISETSFST
990
TPTDRTATSL
1000
SDGILPPQPT
1010
AAHSSATPVP
1020
VTHMFSLPVN
1030
GSSVVAEETE
1040
VTMSEPSTLA
1050
RAFSTSVLSD
1060
VSNLSSTTMT
1070
TALVPPLDQT
1080
ASTTIVIVPT
1090
HGDLIRTTSE
1100
ATVISVRKTS
1110
MAVPSLTETP
1120
FHSLRLSTPV
1130
TAKAETTLFS
1140
TSVDTVTPST
1150
HTLVCSKPPP
1160
DNIPPASSTH
1170
VISTTSTPEA
1180
TQPISQVEET
1190
STYALSFPYT
1200
FSGGGVVASL
1210
ATGTTETSVV
1220
DETTPSHISA
1230
NKLTTSVNSH
1240
ISSSATYRVH
1250
TPVSIQLVTS
1260
TSVLSSDKDQ
1270
MTISLGKTPR
1280
TMEVTEMSPS
1290
KNSFISYSRG
1300
TPSLEMTDTG
1310
FPETTKISSH
1320
QTHSPSEIPL
1330
GTPSDGNLAS
1340
SPTSGSTQIT
1350
PTLTSSNTVG
1360
VHIPEMSTSL
1370
GKTALPSQAL
1380
TITTFLCPEK
1390
ESTSALPAYT
1400
PRTVEMIVNS
1410
TYVTHSVSYG
1420
QDTSFVDTTT
1430
SSSTRISNPM
1440
DINTTFSHLH
1450
SLRTQPEVTS
1460
VASFISESTQ
1470
TFPESLSLST
1480
AGLYNDGFTV
1490
LSDRITTAFS
1500
VPNVPTMLPR
1510
ESSMATSTPI
1520
YQMSSLPVNV
1530
TAFTSKKVSD
1540
TPPIVITKSS
1550
KTMHPGCLKS
1560
PCTATSGPMS
1570
EMSSIPVNNS
1580
AFTPATVSSD
1590
TSTRVGLFST
1600
LLSSVTPRTT
1610
MTMQTSTLDV
1620
TPVIYAGATS
1630
KNKMVSSAFT
1640
TEMIEAPSRI
1650
TPTTFLSPTE
1660
PTLPFVKTVP
1670
TTIMAGIVTP
1680
FVGTTAFSPL
1690
SSKSTGAISS
1700
IPKTTFSPFL
1710
SATQQSSQAD
1720
EATTLGILSG
1730
ITNRSLSTVN
1740
SGTGVALTDT
1750
YSRITVPENM
1760
LSPTHADSLH
1770
TSFNIQVSPS
1780
LTSFKSASGP
1790
TKNVKTTTNC
1800
FSSNTRKMTS
1810
LLEKTSLTNY
1820
ATSLNTPVSY
1830
PPWTPSSATL
1840
PSLTSFVYSP
1850
HSTEAEISTP
1860
KTSPPPTSQM
1870
VEFPVLGTRM
1880
TSSNTQPLLM
1890
TSWNIPTAEG
1900
SQFPISTTIN
1910
VPTSNEMETE
1920
TLHLVPGPLS
1930
TFTASQTGLV
1940
SKDVMAMSSI
1950
PMSGILPNHG
1960
LSENPSLSTS
1970
LRAITSTLAD
1980
VKHTFEKMTT
1990
SVTPGTTLPS
2000
ILSGATSGSV
2010
ISKSPILTWL
2020
LSSLPSGSPP
2030
ATVSNAPHVM
2040
TSSTVEVSKS
2050
TFLTSDMISA
2060
HPFTNLTTLP
2070
SATMSTILTR
2080
TIPTPTLGGI
2090
TTGFPTSLPM
2100
SINVTDDIVY
2110
ISTHPEASSR
2120
TTITANPRTV
2130
SHPSSFSRKT
2140
MSPSTTDHTL
2150
SVGAMPLPSS
2160
TITSSWNRIP
2170
TASSPSTLII
2180
PKPTLDSLLN
2190
IMTTTSTVPG
2200
ASFPLISTGV
2210
TYPFTATVSS
2220
PISSFFETTW
2230
LDSTPSFLST
2240
EASTSPTATK
2250
STVSFYNVEM
2260
SFSVFVEEPR
2270
IPITSVINEF
2280
TENSLNSIFQ
2290
NSEFSLATLE
2300
TQIKSRDISE
2310
EEMVMDRAIL
2320
EQREGQEMAT
2330
ISYVPYSCVC
2340
QVIIKASSSL
2350
ASSELMRKIK
2360
SKIHGNFTHG
2370
NFTQDQLTLL
2380
VNCEHVAVKK
2390
LEPGNCKADE
2400
TASKYKGTYK
2410
WLLTNPTETA
2420
QTRCIKNEDG
2430
NATRFCSISI
2440
NTGKSQWEKP
2450
KFKQCKLLQE
2460
LPDKIVDLAN
2470
ITISDENAED
2480
VAEHILNLIN
2490
ESPALGKEET
2500
KIIVSKISDI
2510
SQCDEISMNL
2520
THVMLQIINV
2530
VLEKQNNSAS
2540
DLHEISNEIL
2550
RIIERTGHKM
2560
EFSGQIANLT
2570
VAGLALAVLR
2580
GDHTFDGMAF
2590
SIHSYEEGTD
2600
PEIFLGNVPV
2610
GGILASIYLP
2620
KSLTERIPLS
2630
NLQTILFNFF
2640
GQTSLFKTKN
2650
VTKALTTYVV
2660
SASISDDMFI
2670
QNLADPVVIT
2680
LQHIGGNQNY
2690
GQVHCAFWDF
2700
ENNNGLGGWN
2710
SSGCKVKETN
2720
VNYTICQCDH
2730
LTHFGVLMDL
2740
SRSTVDSVNE
2750
QILALITYTG
2760
CGISSIFLGV
2770
AVVTYIAFHK
2780
LRKDYPAKIL
2790
INLCTALLML
2800
NLVFLINSWL
2810
SSFQKVGVCI
2820
TAAVALHYFL
2830
LVSFTWMGLE
2840
AVHMYLALVK
2850
VFNIYIPNYI
2860
LKFCLVGWGI
2870
PAIMVAITVS
2880
VKKDLYGTLS
2890
PTTPFCWIKD
2900
DSIFYISVVA
2910
YFCLIFLMNL
2920
SMFCTVLVQL
2930
NSVKSQIQKT
2940
RRKMILHDLK
2950
GTMSLTFLLG
2960
LTWGFAFFAW
2970
GPMRNFFLYL
2980
FAIFNTLQGF
2990
FIFVFHCVMK
3000
ESVREQWQIH
3010
LCCGWLRLDN
3020
SSDGSSRCQI
3030
KVGYKQEGLK
3040
KIFEHKLLTP
3050
SLKSTATSST
3060
FKSLGSAQGT
3070
PSEISFPNDD
3080
FDKDPYCSSP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0004930 | G protein-coupled receptor activity |
| Biological Process | GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| Biological Process | GO:0007166 | cell surface receptor signaling pathway |
| Biological Process | GO:0007186 | G protein-coupled receptor signaling pathway |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.