Search Results

Overview

Uniprot ID	Q8IZH2
Protein Name	5'-3' exoribonuclease 1
Gene Name	XRN1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1364	RMLKEILKIDGSNTV
1681	GHSISHHKSTPISSS
1694	SSRRKSRKLAVNFGV

Function

Major 5'-3' exoribonuclease involved in mRNA decay (PubMed:18172165, PubMed:33472058). Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates (By similarity). The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex (By similarity). Plays a role in replication-dependent histone mRNA degradation (PubMed:18172165). May act as a tumor suppressor protein in osteogenic sarcoma (OGS) (PubMed:12426100)

Protein Sequence

10 MGVPKFYRWI 20 SERYPCLSEV 30 VKEHQIPEFD 40 NLYLDMNGII 50 HQCSHPNDDD 60 VHFRISDDKI 70 FTDIFHYLEV 80 LFRIIKPRKV 90 FFMAVDGVAP 100 RAKMNQQRGR 110 RFRSAKEAED 120 KIKKAIEKGE 130 TLPTEARFDS 140 NCITPGTEFM 150 ARLHEHLKYF 160 VNMKISTDKS 170 WQGVTIYFSG 180 HETPGEGEHK 190 IMEFIRSEKA 200 KPDHDPNTRH 210 CLYGLDADLI 220 MLGLTSHEAH 230 FSLLREEVRF 240 GGKKTQRVCA 250 PEETTFHLLH 260 LSLMREYIDY 270 EFSVLKEKIT 280 FKYDIERIID 290 DWILMGFLVG 300 NDFIPHLPHL 310 HINHDALPLL 320 YGTYVTILPE 330 LGGYINESGH 340 LNLPRFEKYL 350 VKLSDFDREH 360 FSEVFVDLKW 370 FESKVGNKYL 380 NEAAGVAAEE 390 ARNYKEKKKL 400 KGQENSLCWT 410 ALDKNEGEMI 420 TSKDNLEDET 430 EDDDLFETEF 440 RQYKRTYYMT 450 KMGVDVVSDD 460 FLADQAACYV 470 QAIQWILHYY 480 YHGVQSWSWY 490 YPYHYAPFLS 500 DIHNISTLKI 510 HFELGKPFKP 520 FEQLLAVLPA 530 ASKNLLPACY 540 QHLMTNEDSP 550 IIEYYPPDFK 560 TDLNGKQQEW 570 EAVVLIPFID 580 EKRLLEAMET 590 CNHSLKKEER 600 KRNQHSECLM 610 CWYDRDTEFI 620 YPSPWPEKFP 630 AIERCCTRYK 640 IISLDAWRVD 650 INKNKITRID 660 QKALYFCGFP 670 TLKHIRHKFF 680 LKKSGVQVFQ 690 QSSRGENMML 700 EILVDAESDE 710 LTVENVASSV 720 LGKSVFVNWP 730 HLEEARVVAV 740 SDGETKFYLE 750 EPPGTQKLYS 760 GRTAPPSKVV 770 HLGDKEQSNW 780 AKEVQGISEH 790 YLRRKGIIIN 800 ETSAVVYAQL 810 LTGRKYQINQ 820 NGEVRLEKQW 830 SKQVVPFVYQ 840 TIVKDIRAFD 850 SRFSNIKTLD 860 DLFPLRSMVF 870 MLGTPYYGCT 880 GEVQDSGDVI 890 TEGRIRVIFS 900 IPCEPNLDAL 910 IQNQHKYSIK 920 YNPGYVLASR 930 LGVSGYLVSR 940 FTGSIFIGRG 950 SRRNPHGDHK 960 ANVGLNLKFN 970 KKNEEVPGYT 980 KKVGSEWMYS 990 SAAEQLLAEY 1000 LERAPELFSY 1010 IAKNSQEDVF 1020 YEDDIWPGEN 1030 ENGAEKVQEI 1040 ITWLKGHPVS 1050 TLSRSSCDLQ 1060 ILDAAIVEKI 1070 EEEVEKCKQR 1080 KNNKKVRVTV 1090 KPHLLYRPLE 1100 QQHGVIPDRD 1110 AEFCLFDRVV 1120 NVRENFSVPV 1130 GLRGTIIGIK 1140 GANREADVLF 1150 EVLFDEEFPG 1160 GLTIRCSPGR 1170 GYRLPTSALV 1180 NLSHGSRSET 1190 GNQKLTAIVK 1200 PQPAVHQHSS 1210 SSSVSSGHLG 1220 ALNHSPQSLF 1230 VPTQVPTKDD 1240 DEFCNIWQSL 1250 QGSGKMQYFQ 1260 PTIQEKGAVL 1270 PQEISQVNQH 1280 HKSGFNDNSV 1290 KYQQRKHDPH 1300 RKFKEECKSP 1310 KAECWSQKMS 1320 NKQPNSGIEN 1330 FLASLNISKE 1340 NEVQSSHHGE 1350 PPSEEHLSPQ 1360 SFAMGTRMLK 1370 EILKIDGSNT 1380 VDHKNEIKQI 1390 ANEIPVSSNR 1400 RDEYGLPSQP 1410 KQNKKLASYM 1420 NKPHSANEYH 1430 NVQSMDNMCW 1440 PAPSQIPPVS 1450 TPVTELSRIC 1460 SLVGMPQPDF 1470 SFLRMPQTMT 1480 VCQVKLSNGL 1490 LVHGPQCHSE 1500 NEAKEKAALF 1510 ALQQLGSLGM 1520 NFPLPSQVFA 1530 NYPSAVPPGT 1540 IPPAFPPPTG 1550 WDHYGSNYAL 1560 GAANIMPSSS 1570 HLFGSMPWGP 1580 SVPVPGKPFH 1590 HTLYSGTMPM 1600 AGGIPGGVHN 1610 QFIPLQVTKK 1620 RVANKKNFEN 1630 KEAQSSQATP 1640 VQTSQPDSSN 1650 IVKVSPRESS 1660 SASLKSSPIA 1670 QPASSFQVET 1680 ASQGHSISHH 1690 KSTPISSSRR 1700 KSRKLAVNFG VSKPSE

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0030425	dendrite
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0043025	neuronal cell body
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0000932	P-body
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0004534	5'-3' RNA exonuclease activity
Molecular Function	GO:0051880	G-quadruplex DNA binding
Molecular Function	GO:0002151	G-quadruplex RNA binding
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0070034	telomerase RNA binding
Biological Process	GO:0071409	cellular response to cycloheximide
Biological Process	GO:1905795	cellular response to puromycin
Biological Process	GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA
Biological Process	GO:0071044	histone mRNA catabolic process
Biological Process	GO:0006402	mRNA catabolic process
Biological Process	GO:0032211	negative regulation of telomere maintenance via telomerase
Biological Process	GO:0017148	negative regulation of translation
Biological Process	GO:0071028	nuclear mRNA surveillance
Biological Process	GO:0000956	nuclear-transcribed mRNA catabolic process
Biological Process	GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Biological Process	GO:0033574	response to testosterone
Biological Process	GO:0016075	rRNA catabolic process

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.