Search Results

Overview

Uniprot ID	Q8IZL2
Protein Name	Mastermind-like protein 2
Gene Name	MAML2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
263	GLFNMGLKEVKKEPG

Function

Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3

Protein Sequence

10 MGDTAPPQAP 20 AGGLGGASGA 30 GLLGGGSVTP 40 RVHSAIVERL 50 RARIAVCRQH 60 HLSCEGRYER 70 GRAESSDRER 80 ESTLQLLSLV 90 QHGQGARKAG 100 KHTKATATAA 110 TTTAPPPPPA 120 APPAASQAAA 130 TAAPPPPPDY 140 HHHHQQHLLN 150 SSNNGGSGGI 160 NGEQQPPAST 170 PGDQRNSALI 180 ALQGSLKRKQ 190 VVNLSPANSK 200 RPNGFVDNSF 210 LDIKRIRVGE 220 NLSAGQGGLQ 230 INNGQSQIMS 240 GTLPMSQAPL 250 RKTNTLPSHT 260 HSPGNGLFNM 270 GLKEVKKEPG 280 ETLSCSKHMD 290 GQMTQENIFP 300 NRYGDDPGEQ 310 LMDPELQELF 320 NELTNISVPP 330 MSDLELENMI 340 NATIKQDDPF 350 NIDLGQQSQR 360 STPRPSLPME 370 KIVIKSEYSP 380 GLTQGPSGSP 390 QLRPPSAGPA 400 FSMANSALST 410 SSPIPSVPQS 420 QAQPQTGSGA 430 SRALPSWQEV 440 SHAQQLKQIA 450 ANRQQHARMQ 460 QHQQQHQPTN 470 WSALPSSAGP 480 SPGPFGQEKI 490 PSPSFGQQTF 500 SPQSSPMPGV 510 AGGSGQSKVM 520 ANYMYKAGPS 530 AQGGHLDVLM 540 QQKPQDLSRS 550 FINNPHPAME 560 PRQGNTKPLF 570 HFNSDQANQQ 580 MPSVLPSQNK 590 PSLLHYTQQQ 600 QQQQQQQQQQ 610 QQQQQQQQQQ 620 QQQQQQQQQQ 630 QSSISAQQQQ 640 QQQSSISAQQ 650 QQQQQQQQQQ 660 QQQQQQQQQQ 670 QQQQQPSSQP 680 AQSLPSQPLL 690 RSPLPLQQKL 700 LLQQMQNQPI 710 AGMGYQVSQQ 720 QRQDQHSVVG 730 QNTGPSPSPN 740 PCSNPNTGSG 750 YMNSQQSLLN 760 QQLMGKKQTL 770 QRQIMEQKQQ 780 LLLQQQMLAD 790 AEKIAPQDQI 800 NRHLSRPPPD 810 YKDQRRNVGN 820 MQPTAQYSGG 830 SSTISLNSNQ 840 ALANPVSTHT 850 ILTPNSSLLS 860 TSHGTRMPSL 870 STAVQNMGMY 880 GNLPCNQPNT 890 YSVTSGMNQL 900 TQQRNPKQLL 910 ANQNNPMMPR 920 PPTLGPSNNN 930 NVATFGAGSV 940 GNSQQLRPNL 950 THSMASMPPQ 960 RTSNVMITSN 970 TTAPNWASQE 980 GTSKQQEALT 990 SAGVRFPTGT 1000 PAAYTPNQSL 1010 QQAVGSQQFS 1020 QRAVAPPNQL 1030 TPAVQMRPMN 1040 QMSQTLNGQT 1050 MGPLRGLNLR 1060 PNQLSTQILP 1070 NLNQSGTGLN 1080 QSRTGINQPP 1090 SLTPSNFPSP 1100 NQSSRAFQGT 1110 DHSSDLAFDF 1120 LSQQNDNMGP 1130 ALNSDADFID 1140 SLLKTEPGND 1150 DWMKDINLDE ILGNNS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0016604	nuclear body
Cellular Component	GO:0016607	nuclear speck
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0003713	transcription coactivator activity
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0007219	Notch signaling pathway
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:0007221	positive regulation of transcription of Notch receptor target

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.