Search Results

Overview

Uniprot ID	Q8IZQ5
Protein Name	Selenoprotein H
Gene Name	SELENOH
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
9	APRGRKRKAEAAVVA

Function

May be involved in a redox-related process

Protein Sequence

10 MAPRGRKRKA 20 EAAVVAVAEK 30 REKLANGGEG 40 MEEATVVIEH 50 CTSURVYGRN 60 AAALSQALRL 70 EAPELPVKVN 80 PTKPRRGSFE 90 VTLLRPDGSS 100 AELWTGIKKG 110 PPRKLKFPEP 120 QEVVEELKKY LS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005794	Golgi apparatus
Molecular Function	GO:0003723	RNA binding

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.