Search Results

Overview

Uniprot IDQ8IZT6
Protein NameAbnormal spindle-like microcephaly-associated protein
Gene NameASPM
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
2188 RVRRTLRKMQTAATL
485 ISSHSHNKQPKRRPI

Function

Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis

Protein Sequence

10 MANRRVGRGC 20 WEVSPTERRP 30 PAGLRGPAAE 40 EEASSPPVLS 50 LSHFCRSPFL 60 CFGDVLLGAS 70 RTLSLALDNP 80 NEEVAEVKIS 90 HFPAADLGFS 100 VSQRCFVLQP 110 KEKIVISVNW 120 TPLKEGRVRE 130 IMTFLVNDVL 140 KHQAILLGNA 150 EEQKKKKRSL 160 WDTIKKKKIS 170 ASTSHNRRVS 180 NIQNVNKTFS 190 VSQKVDRVRS 200 PLQACENLAM 210 NEGGPPTENN 220 SLILEENKIP 230 ISPISPAFNE 240 CHGATCLPLS 250 VRRSTTYSSL 260 HASENRELLN 270 VHSANVSKVS 280 FNEKAVTETS 290 FNSVNVNGQR 300 GENSKLSLTP 310 NCSSTLNITQ 320 SQIHFLSPDS 330 FVNNSHGANN 340 ELELVTCLSS 350 DMFMKDNSQP 360 VHLESTIAHE 370 IYQKILSPDS 380 FIKDNYGLNQ 390 DLESESVNPI 400 LSPNQFLKDN 410 MAYMCTSQQT 420 CKVPLSNENS 430 QVPQSPEDWR 440 KSEVSPRIPE 450 CQGSKSPKAI 460 FEELVEMKSN 470 YYSFIKQNNP 480 KFSAVQDISS 490 HSHNKQPKRR 500 PILSATVTKR 510 KATCTRENQT 520 EINKPKAKRC 530 LNSAVGEHEK 540 VINNQKEKED 550 FHSYLPIIDP 560 ILSKSKSYKN 570 EVTPSSTTAS 580 VARKRKSDGS 590 MEDANVRVAI 600 TEHTEVREIK 610 RIHFSPSEPK 620 TSAVKKTKNV 630 TTPISKRISN 640 REKLNLKKKT 650 DLSIFRTPIS 660 KTNKRTKPII 670 AVAQSSLTFI 680 KPLKTDIPRH 690 PMPFAAKNMF 700 YDERWKEKQE 710 QGFTWWLNFI 720 LTPDDFTVKT 730 NISEVNAATL 740 LLGIENQHKI 750 SVPRAPTKEE 760 MSLRAYTARC 770 RLNRLRRAAC 780 RLFTSEKMVK 790 AIKKLEIEIE 800 ARRLIVRKDR 810 HLWKDVGERQ 820 KVLNWLLSYN 830 PLWLRIGLET 840 TYGELISLED 850 NSDVTGLAMF 860 ILNRLLWNPD 870 IAAEYRHPTV 880 PHLYRDGHEE 890 ALSKFTLKKL 900 LLLVCFLDYA 910 KISRLIDHDP 920 CLFCKDAEFK 930 ASKEILLAFS 940 RDFLSGEGDL 950 SRHLGLLGLP 960 VNHVQTPFDE 970 FDFAVTNLAV 980 DLQCGVRLVR 990 TMELLTQNWD 1000 LSKKLRIPAI 1010 SRLQKMHNVD 1020 IVLQVLKSRG 1030 IELSDEHGNT 1040 ILSKDIVDRH 1050 REKTLRLLWK 1060 IAFAFQVDIS 1070 LNLDQLKEEI 1080 AFLKHTKSIK 1090 KTISLLSCHS 1100 DDLINKKKGK 1110 RDSGSFEQYS 1120 ENIKLLMDWV 1130 NAVCAFYNKK 1140 VENFTVSFSD 1150 GRVLCYLIHH 1160 YHPCYVPFDA 1170 ICQRTTQTVE 1180 CTQTGSVVLN 1190 SSSESDDSSL 1200 DMSLKAFDHE 1210 NTSELYKELL 1220 ENEKKNFHLV 1230 RSAVRDLGGI 1240 PAMINHSDMS 1250 NTIPDEKVVI 1260 TYLSFLCARL 1270 LDLRKEIRAA 1280 RLIQTTWRKY 1290 KLKTDLKRHQ 1300 EREKAARIIQ 1310 LAVINFLAKQ 1320 RLRKRVNAAL 1330 VIQKYWRRVL 1340 AQRKLLMLKK 1350 EKLEKVQNKA 1360 ASLIQGYWRR 1370 YSTRQRFLKL 1380 KYYSIILQSR 1390 IRMIIAVTSY 1400 KRYLWATVTI 1410 QRHWRAYLRR 1420 KQDQQRYEML 1430 KSSTLIIQSM 1440 FRKWKQRKMQ 1450 SQVKATVILQ 1460 RAFREWHLRK 1470 QAKEENSAII 1480 IQSWYRMHKE 1490 LRKYIYIRSC 1500 VVIIQKRFRC 1510 FQAQKLYKRR 1520 KESILTIQKY 1530 YKAYLKGKIE 1540 RTNYLQKRAA 1550 AIQLQAAFRR 1560 LKAHNLCRQI 1570 RAACVIQSYW 1580 RMRQDRVRFL 1590 NLKKTIIKFQ 1600 AHVRKHQQRQ 1610 KYKKMKKAAV 1620 IIQTHFRAYI 1630 FAMKVLASYQ 1640 KTRSAVIVLQ 1650 SAYRGMQARK 1660 MYIHILTSVI 1670 KIQSYYRAYV 1680 SKKEFLSLKN 1690 ATIKLQSTVK 1700 MKQTRKQYLH 1710 LRAAALFIQQ 1720 CYRSKKIAAQ 1730 KREEYMQMRE 1740 SCIKLQAFVR 1750 GYLVRKQMRL 1760 QRKAVISLQS 1770 YFRMRKARQY 1780 YLKMYKAIIV 1790 IQNYYHAYKA 1800 QVNQRKNFLQ 1810 VKKAATCLQA 1820 AYRGYKVRQL 1830 IKQQSIAALK 1840 IQSAFRGYNK 1850 RVKYQSVLQS 1860 IIKIQRWYRA 1870 YKTLHDTRTH 1880 FLKTKAAVIS 1890 LQSAYRGWKV 1900 RKQIRREHQA 1910 ALKIQSAFRM 1920 AKAQKQFRLF 1930 KTAALVIQQN 1940 FRAWTAGRKQ 1950 CMEYIELRHA 1960 VLVLQSMWKG 1970 KTLRRQLQRQ 1980 HKCAIIIQSY 1990 YRMHVQQKKW 2000 KIMKKAALLI 2010 QKYYRAYSIG 2020 REQNHLYLKT 2030 KAAVVTLQSA 2040 YRGMKVRKRI 2050 KDCNKAAVTI 2060 QSKYRAYKTK 2070 KKYATYRASA 2080 IIIQRWYRGI 2090 KITNHQHKEY 2100 LNLKKTAIKI 2110 QSVYRGIRVR 2120 RHIQHMHRAA 2130 TFIKAMFKMH 2140 QSRISYHTMR 2150 KAAIVIQVRC 2160 RAYYQGKMQR 2170 EKYLTILKAV 2180 KVLQASFRGV 2190 RVRRTLRKMQ 2200 TAATLIQSNY 2210 RRYRQQTYFN 2220 KLKKITKTVQ 2230 QRYWAMKERN 2240 IQFQRYNKLR 2250 HSVIYIQAIF 2260 RGKKARRHLK 2270 MMHIAATLIQ 2280 RRFRTLMMRR 2290 RFLSLKKTAI 2300 LIQRKYRAHL 2310 CTKHHLQFLQ 2320 VQNAVIKIQS 2330 SYRRWMIRKR 2340 MREMHRAATF 2350 IQSTFRMHRL 2360 HMRYQALKQA 2370 SVVIQQQYQA 2380 NRAAKLQRQH 2390 YLRQRHSAVI 2400 LQAAFRGMKT 2410 RRHLKSMHSS 2420 ATLIQSRFRS 2430 LLVRRRFISL 2440 KKATIFVQRK 2450 YRATICAKHK 2460 LYQFLHLRKA 2470 AITIQSSYRR 2480 LMVKKKLQEM 2490 QRAAVLIQAT 2500 FRMYRTYITF 2510 QTWKHASILI 2520 QQHYRTYRAA 2530 KLQRENYIRQ 2540 WHSAVVIQAA 2550 YKGMKARQLL 2560 REKHKASIVI 2570 QSTYRMYRQY 2580 CFYQKLQWAT 2590 KIIQEKYRAN 2600 KKKQKVFQHN 2610 ELKKETCVQA 2620 GFQDMNIKKQ 2630 IQEQHQAAII 2640 IQKHCKAFKI 2650 RKHYLHLRAT 2660 VVSIQRRYRK 2670 LTAVRTQAVI 2680 CIQSYYRGFK 2690 VRKDIQNMHR 2700 AATLIQSFYR 2710 MHRAKVDYET 2720 KKTAIVVIQN 2730 YYRLYVRVKT 2740 ERKNFLAVQK 2750 SVRTIQAAFR 2760 GMKVRQKLKN 2770 VSEEKMAAIV 2780 NQSALCCYRS 2790 KTQYEAVQSE 2800 GVMIQEWYKA 2810 SGLACSQEAE 2820 YHSQSRAAVT 2830 IQKAFCRMVT 2840 RKLETQKCAA 2850 LRIQFFLQMA 2860 VYRRRFVQQK 2870 RAAITLQHYF 2880 RTWQTRKQFL 2890 LYRKAAVVLQ 2900 NHYRAFLSAK 2910 HQRQVYLQIR 2920 SSVIIIQARS 2930 KGFIQKRKFQ 2940 EIKNSTIKIQ 2950 AMWRRYRAKK 2960 YLCKVKAACK 2970 IQAWYRCWRA 2980 HKEYLAILKA 2990 VKIIQGCFYT 3000 KLERTRFLNV 3010 RASAIIIQRK 3020 WRAILPAKIA 3030 HEHFLMIKRH 3040 RAACLIQAHY 3050 RGYKGRQVFL 3060 RQKSAALIIQ 3070 KYIRAREAGK 3080 HERIKYIEFK 3090 KSTVILQALV 3100 RGWLVRKRFL 3110 EQRAKIRLLH 3120 FTAAAYYHLN 3130 AVRIQRAYKL 3140 YLAVKNANKQ 3150 VNSVICIQRW 3160 FRARLQEKRF 3170 IQKYHSIKKI 3180 EHEGQECLSQ 3190 RNRAASVIQK 3200 AVRHFLLRKK 3210 QEKFTSGIIK 3220 IQALWRGYSW 3230 RKKNDCTKIK 3240 AIRLSLQVVN 3250 REIREENKLY 3260 KRTALALHYL 3270 LTYKHLSAIL 3280 EALKHLEVVT 3290 RLSPLCCENM 3300 AQSGAISKIF 3310 VLIRSCNRSI 3320 PCMEVIRYAV 3330 QVLLNVSKYE 3340 KTTSAVYDVE 3350 NCIDILLELL 3360 QIYREKPGNK 3370 VADKGGSIFT 3380 KTCCLLAILL 3390 KTTNRASDVR 3400 SRSKVVDRIY 3410 SLYKLTAHKH 3420 KMNTERILYK 3430 QKKNSSISIP 3440 FIPETPVRTR 3450 IVSRLKPDWV 3460 LRRDNMEEIT 3470 NPLQAIQMVM DTLGIPY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016324 apical plasma membrane
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0072687 meiotic spindle
Cellular Component GO:0036449 microtubule minus-end
Cellular Component GO:0030496 midbody
Cellular Component GO:0097431 mitotic spindle pole
Cellular Component GO:0005634 nucleus
Molecular Function GO:0005516 calmodulin binding
Biological Process GO:0051301 cell division
Biological Process GO:0051445 regulation of meiotic cell cycle
Biological Process GO:0051653 spindle localization
Biological Process GO:0007051 spindle organization

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.