Search Results

Overview

Uniprot ID	Q8K1Z0
Protein Name	Ubiquinone biosynthesis protein COQ9, mitochondrial
Gene Name	Coq9
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
170	VQLGQAEKRKTDQFL
172	LGQAEKRKTDQFLRD

Function

Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to COQ7, therefore facilitating the COQ7-mediated hydroxylase step (By similarity). Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:23255162, PubMed:25339443)

Protein Sequence

10 MAATAAVSGV 20 LGRLGWRLLQ 30 LRCLPVARCR 40 PALVPRAFHT 50 AVGFRSSEEQ 60 KQQPPHSSSQ 70 QHSETQGPEF 80 SRPPPRYTDQ 90 SGEEEEDYES 100 EEQLQHRILT 110 AALEFVPAHG 120 WTAEAIAEGA 130 QSLGLSSAAA 140 SMFGSDGSEL 150 ILHFVTQCNA 160 RLNQVLEEEQ 170 KLVQLGQAEK 180 RKTDQFLRDA 190 VETRLRMLIP 200 YIEHWPRALS 210 ILLLPHNIPP 220 SLNLLTSMVD 230 DMWHYAGDQS 240 TDFNWYTRRA 250 VLAGIYNTTE 260 LVMMQDSSPD 270 FEDTWRFLEN 280 RINDAMNMGH 290 TAKQVKSTGE 300 ALVQGLMGAA 310 VTLKNLTGLN QRR

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005743	mitochondrial inner membrane
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0110142	ubiquinone biosynthesis complex
Molecular Function	GO:0008047	enzyme activator activity
Molecular Function	GO:0019840	isoprenoid binding
Molecular Function	GO:0008289	lipid binding
Molecular Function	GO:0042803	protein homodimerization activity
Biological Process	GO:0006120	mitochondrial electron transport, NADH to ubiquinone
Biological Process	GO:0006744	ubiquinone biosynthetic process

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.