Search Results

Overview

Uniprot IDQ8K2B3
Protein NameSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Gene NameSdha
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
167 FSRTEDGKIYQRAFG
179 AFGGQSLKFGKGGQA
182 GQSLKFGKGGQAHRC
250 SIHRIRAKNTVIATG
335 ERYAPVAKDLASRDV
480 ESCRPGDKVPSIKAN
485 GDKVPSIKANAGEES
498 ESVMNLDKLRFADGS
517 ELRLNMQKSMQNHAA
547 SQLYGDLKHLKTFDR
550 YGDLKHLKTFDRGMV
608 VDEYDYSKPIQGQQK
615 KPIQGQQKKPFGEHW
616 PIQGQQKKPFGEHWR
624 PFGEHWRKHTLSYVD
633 TLSYVDIKTGKVTLE
636 YVDIKTGKVTLEYRP

Function

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (By similarity). Can act as a tumor suppressor (By similarity)

Protein Sequence

10 MAGVGAVSRL 20 LRGRRLALTG 30 AWPGTLQKQT 40 CGFHFSVGEN 50 KKASAKVSDA 60 ISTQYPVVDH 70 EFDAVVVGAG 80 GAGLRAAFGL 90 SEAGFNTACL 100 TKLFPTRSHT 110 VAAQGGINAA 120 LGNMEEDNWR 130 WHFYDTVKGS 140 DWLGDQDAIH 150 YMTEQAPASV 160 VELENYGMPF 170 SRTEDGKIYQ 180 RAFGGQSLKF 190 GKGGQAHRCC 200 CVADRTGHSL 210 LHTLYGRSLR 220 YDTSYFVEYF 230 ALDLLMENGE 240 CRGVIALCIE 250 DGSIHRIRAK 260 NTVIATGGYG 270 RTYFSCTSAH 280 TSTGDGTAMV 290 TRAGLPCQDL 300 EFVQFHPTGI 310 YGAGCLITEG 320 CRGEGGILIN 330 SQGERFMERY 340 APVAKDLASR 350 DVVSRSMTLE 360 IREGRGCGPE 370 KDHVYLQLHH 380 LPPEQLATRL 390 PGISETAMIF 400 AGVDVTKEPI 410 PVLPTVHYNM 420 GGIPTNYKGQ 430 VLKHVNGQDQ 440 IVPGLYACGE 450 AACASVHGAN 460 RLGANSLLDL 470 VVFGRACALS 480 IAESCRPGDK 490 VPSIKANAGE 500 ESVMNLDKLR 510 FADGSIRTSE 520 LRLNMQKSMQ 530 NHAAVFRVGS 540 VLQEGCEKIS 550 QLYGDLKHLK 560 TFDRGMVWNT 570 DLVETLELQN 580 LMLCALQTIY 590 GAEARKESRG 600 AHAREDYKVR 610 VDEYDYSKPI 620 QGQQKKPFGE 630 HWRKHTLSYV 640 DIKTGKVTLE 650 YRPVIDKTLN 660 EADCATVPPA IRSY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0043209 myelin sheath
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0045273 respiratory chain complex II (succinate dehydrogenase)
Molecular Function GO:0009055 electron transfer activity
Molecular Function GO:0050660 flavin adenine dinucleotide binding
Molecular Function GO:0008177 succinate dehydrogenase (quinone) activity
Biological Process GO:0006121 mitochondrial electron transport, succinate to ubiquinone
Biological Process GO:0007399 nervous system development
Biological Process GO:0042776 proton motive force-driven mitochondrial ATP synthesis
Biological Process GO:0022904 respiratory electron transport chain
Biological Process GO:0006105 succinate metabolic process
Biological Process GO:0006099 tricarboxylic acid cycle

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.