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Overview

Uniprot ID	Q8K3A0
Protein Name	Iron-sulfur cluster co-chaperone protein HscB
Gene Name	Hscb
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
118	TEKHFSDKHSTLVND

Function

Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria. Required for incorporation of iron-sulfur clusters into SDHB, the iron-sulfur protein subunit of succinate dehydrogenase that is involved in complex II of the mitochondrial electron transport chain. Recruited to SDHB by interaction with SDHAF1 which first binds SDHB and then recruits the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20 (By similarity). Plays an essential role in hematopoiesis (PubMed:32634119)

Protein Sequence

10 MWGCGARALL 20 GVWEVRLAGF 30 LGRRLLGSNA 40 AAGKSIAPQC 50 WNCGHAREAG 60 CGDEFFCSHC 70 RALQPPDPTR 80 DYFSLMNCNR 90 SFRVDVTKLQ 100 HRYQQLQRLV 110 HPDFFSQKSQ 120 TEKHFSDKHS 130 TLVNDAYKTL 140 QAPLTRGLYL 150 LKLQGIEIPE 160 GTDYKADSQF 170 LVEIMEINER 180 LADAQSEAAM 190 EEIEATVRAK 200 QKEFTDNINS 210 AFEQGDFEKA 220 KELLTKMRYF 230 SNIEEKIKLS KTPL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0005654	nucleoplasm
Molecular Function	GO:0001671	ATPase activator activity
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0051087	protein-folding chaperone binding
Biological Process	GO:0044571	[2Fe-2S] cluster assembly
Biological Process	GO:0030218	erythrocyte differentiation
Biological Process	GO:0016226	iron-sulfur cluster assembly
Biological Process	GO:0060319	primitive erythrocyte differentiation
Biological Process	GO:0060215	primitive hemopoiesis
Biological Process	GO:0051259	protein complex oligomerization

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.