Search Results

Overview

Uniprot ID	Q8K3J1
Protein Name	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
Gene Name	Ndufs8
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
42	TYKYVNKKEQESEVD
51	QESEVDMKSATDNAA

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:38575788). Essential for the catalytic activity and assembly of complex I (By similarity)

Protein Sequence

10 MYRLSSSMLP 20 RALAQAMRTG 30 HLNGQSLHSS 40 AVAATYKYVN 50 KKEQESEVDM 60 KSATDNAARI 70 LMWTELIRGL 80 GMTLSYLFRE 90 PATINYPFEK 100 GPLSPRFRGE 110 HALRRYPSGE 120 ERCIACKLCE 130 AICPAQAITI 140 EAEPRADGSR 150 RTTRYDIDMT 160 KCIYCGFCQE 170 ACPVDAIVEG 180 PNFEFSTETH 190 EELLYNKEKL 200 LNNGDKWEAE 210 IAANIQADYL YR

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005743	mitochondrial inner membrane
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0045271	respiratory chain complex I
Molecular Function	GO:0051539	4 iron, 4 sulfur cluster binding
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0008137	NADH dehydrogenase (ubiquinone) activity
Molecular Function	GO:0003954	NADH dehydrogenase activity
Biological Process	GO:0009060	aerobic respiration
Biological Process	GO:0006120	mitochondrial electron transport, NADH to ubiquinone
Biological Process	GO:0032981	mitochondrial respiratory chain complex I assembly
Biological Process	GO:0042776	proton motive force-driven mitochondrial ATP synthesis

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.