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Overview

Uniprot ID	Q8K4F5
Protein Name	sn-1-specific diacylglycerol lipase ABHD11
Gene Name	Abhd11
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
196	QARKLADKQLSSVVK
79	TNFNSLAKAMVQRTG

Function

Catalyzes the hydrolysis of diacylglycerol in vitro and may function as a key regulator in lipid metabolism, namely by regulating the intracellular levels of diacylglycerol (By similarity). 1,2-diacyl-sn-glycerols are the preferred substrate over 1,3-diacyl-sn-glycerols. The enzyme hydrolyzes stearate in preference to palmitate from the sn-1 position of 1,2-diacyl-sn-glycerols (By similarity). Maintains the functional lipoylation of the 2-oxoglutarate dehydrogenase complex (OGDHc) through its interaction with the OGDHc by preventing the formation of lipoyl adducts (By similarity). In addition, is also required for the expansion and differentiation of embryonic stem cells (ESCs) (PubMed:32733886)

Protein Sequence

10 MLRWARAWRV 20 PRGVLGASSP 30 RRLAVPVTFC 40 SSRSSGQENA 50 DLRPLPLSYN 60 LLDGDATLPA 70 IVFLHGLFGS 80 KTNFNSLAKA 90 MVQRTGRRVL 100 TVDARNHGDS 110 PHSPDASYEA 120 MSQDLQGLLP 130 QLGLVPCVLV 140 GHSMGGKTAM 150 LLALQRPDVV 160 ERLVVVDISP 170 VGTTPGSHIG 180 AFIAAMKAVE 190 IPEKVPHSQA 200 RKLADKQLSS 210 VVKEAGIRQF 220 LLTNLVEVGG 230 RFSWRLNLDT 240 LAQHLDKIMT 250 FPQQREPYSG 260 PTLFLLGGNS 270 TYVQPSHHSE 280 IRRLFPQAQI 290 QTVPNAGHWV 300 HSDKPQDFMD AVTSFLA

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0045252	oxoglutarate dehydrogenase complex
Molecular Function	GO:0052689	carboxylic ester hydrolase activity
Molecular Function	GO:0016298	lipase activity
Biological Process	GO:0006629	lipid metabolic process

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.