Search Results

Overview

Uniprot ID	Q8K4Z3
Protein Name	NAD(P)H-hydrate epimerase
Gene Name	Naxe
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
142	YYPKRPNKPLFTGLV
263	FVPPALEKKYQLNLP

Function

Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) (PubMed:21994945). This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity). Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis (By similarity)

Protein Sequence

10 MSGLRTLLGL 20 GLLVAGSRLP 30 RVISQQSVCR 40 ARPIWWGTQR 50 RGSETMAGAA 60 VKYLSQEEAQ 70 AVDQELFNEY 80 QFSVDQLMEL 90 AGLSCATAIA 100 KAYPPTSMSK 110 SPPTVLVICG 120 PGNNGGDGLV 130 CARHLKLFGY 140 QPTIYYPKRP 150 NKPLFTGLVT 160 QCQKMDIPFL 170 GEMPPEPMMV 180 DELYELVVDA 190 IFGFSFKGDV 200 REPFHSILSV 210 LSGLTVPIAS 220 IDIPSGWDVE 230 KGNPSGIQPD 240 LLISLTAPKK 250 SATHFTGRYH 260 YLGGRFVPPA 270 LEKKYQLNLP 280 SYPDTECVYR LQ

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0044297	cell body
Cellular Component	GO:0005929	cilium
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0052856	NAD(P)HX epimerase activity
Molecular Function	GO:0000166	nucleotide binding
Biological Process	GO:0006869	lipid transport
Biological Process	GO:0031580	membrane raft distribution
Biological Process	GO:0110051	metabolite repair
Biological Process	GO:0016525	negative regulation of angiogenesis
Biological Process	GO:0046496	nicotinamide nucleotide metabolic process
Biological Process	GO:0010874	regulation of cholesterol efflux
Biological Process	GO:0002040	sprouting angiogenesis

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.