Search Results

Overview

Uniprot IDQ8K4Z4
Protein NameBeta-2 adrenergic receptor
Gene NameAdrb2
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
228 RVFQVAKKQLQKIDR

Function

G protein-coupled receptor for catecholamines that couples to both G(s) and G(i) proteins, activating bifurcated signaling pathways (PubMed:12460637). ADRB2 binds epinephrine (Epi) with an approximately 30-fold greater affinity than norepinephrine (NE) (By similarity). In the heart, Epi- and NE-activated ADRB2 induces rapid and slow cardiomyocyte contraction rate, respectively. Both NE and Epi promote coupling to G(s)/PKA pathway to regulate myocyte contraction rate. Epi also promotes ADRB2 coupling to G(i) proteins to exert cardioprotective effects especially in the conditions of hypoxia and oxidative stress through the G(i)/PI3K/Akt signaling pathway. ADRB2-G(s) signaling delivers proapoptotic signals in cardiomyocytes although G(i)-mediated survival effect appears to predominate (By similarity). ADRB2 also transduces signals independently of PKA to regulate cellular pH by modulating Na(+)/H(+) exchanger SLC9A3 function (By similarity)

Protein Sequence

10 MGHLGNGSDF 20 LLAPNASHAP 30 DHNVTRERDE 40 AWVVGMAIVM 50 SLIVLAIVFG 60 NVLVITAIAK 70 FERLQTVTNY 80 FITSLACADL 90 VMGLAVVPFG 100 ASHILMNMWT 110 FGNFWCEFWT 120 SIDVLCVTAS 130 IETLCVIAVD 140 RYFAITSPFK 150 YQSLLTKNKA 160 RVVILMVWVV 170 SGLTSFLPIQ 180 MHWYRATHKD 190 AINCYAEETC 200 CDFFTNQAYA 210 IASSIVSFYL 220 PLVVMVFVYS 230 RVFQVAKKQL 240 QKIDRSEGRF 250 HTQNLSQVEQ 260 DGRSGHGLRR 270 SSKFYLKEHK 280 ALKTLGIIMG 290 TFTLCWLPFF 300 IVNIVHVIQD 310 NLIPKEVYIL 320 LNWVGYVNSA 330 FNPLIYCRSP 340 DFRIAFQELL 350 CLRRSALKAY 360 GNDCSSNSNG 370 KTDYTGEPNV 380 CHQGQEKERE 390 LLCEDPPGTE 400 DLVSCPGTVP 410 SDSIDSQGRN YSTNDSLL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016324 apical plasma membrane
Cellular Component GO:0005769 early endosome
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0098992 neuronal dense core vesicle
Cellular Component GO:0005634 nucleus
Cellular Component GO:0043235 receptor complex
Molecular Function GO:0008179 adenylate cyclase binding
Molecular Function GO:0001540 amyloid-beta binding
Molecular Function GO:0004941 beta2-adrenergic receptor activity
Molecular Function GO:0051380 norepinephrine binding
Molecular Function GO:0015459 potassium channel regulator activity
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0044877 protein-containing complex binding
Biological Process GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway
Biological Process GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway
Biological Process GO:0098990 AMPA selective glutamate receptor signaling pathway
Biological Process GO:1904646 cellular response to amyloid-beta
Biological Process GO:0010667 negative regulation of cardiac muscle cell apoptotic process
Biological Process GO:0045744 negative regulation of G protein-coupled receptor signaling pathway
Biological Process GO:0051241 negative regulation of multicellular organismal process
Biological Process GO:0002025 norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure
Biological Process GO:1901098 positive regulation of autophagosome maturation
Biological Process GO:0010666 positive regulation of cardiac muscle cell apoptotic process
Biological Process GO:0106134 positive regulation of cardiac muscle cell contraction
Biological Process GO:0120162 positive regulation of cold-induced thermogenesis
Biological Process GO:1900451 positive regulation of glutamate receptor signaling pathway
Biological Process GO:1904504 positive regulation of lipophagy
Biological Process GO:0043410 positive regulation of MAPK cascade
Biological Process GO:0061885 positive regulation of mini excitatory postsynaptic potential
Biological Process GO:0006898 receptor-mediated endocytosis
Biological Process GO:0048638 regulation of developmental growth
Biological Process GO:0006940 regulation of smooth muscle contraction

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.