Search Results

Overview

Uniprot IDQ8N0X7
Protein NameSpartin
Gene NameSPART
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
377 KQLDQGNKDVRHKGK
390 GKRGKRAKDTSSEEV
447 KGAEITGKAIQKGAS
475 EVSPAVTKGLYIAKQ
481 TKGLYIAKQATGGAA
514 KELAPHVKKHGSKLV
519 HVKKHGSKLVPESLK
615 GIKAMVKKTATQTGH

Function

Lipophagy receptor that plays an important role in lipid droplet (LD) turnover in motor neurons (PubMed:37443287). Localizes to LDs and interacts with components of the autophagy machinery, such as MAP1LC3A/C proteins to deliver LDs to autophagosomes for degradation via lipophagy (PubMed:37443287). Lipid transfer protein required for lipid droplet degradation, including by lipophagy (PubMed:38190532). Can bind and transfer all lipid species found in lipid droplets, from phospholipids to triglycerides and sterol esters but the direction of lipid transfer by spartin and its cargos are unknown (PubMed:38190532). May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis (PubMed:20719964)

Protein Sequence

10 MEQEPQNGEP 20 AEIKIIREAY 30 KKAFLFVNKG 40 LNTDELGQKE 50 EAKNYYKQGI 60 GHLLRGISIS 70 SKESEHTGPG 80 WESARQMQQK 90 MKETLQNVRT 100 RLEILEKGLA 110 TSLQNDLQEV 120 PKLYPEFPPK 130 DMCEKLPEPQ 140 SFSSAPQHAE 150 VNGNTSTPSA 160 GAVAAPASLS 170 LPSQSCPAEA 180 PPAYTPQAAE 190 GHYTVSYGTD 200 SGEFSSVGEE 210 FYRNHSQPPP 220 LETLGLDADE 230 LILIPNGVQI 240 FFVNPAGEVS 250 APSYPGYLRI 260 VRFLDNSLDT 270 VLNRPPGFLQ 280 VCDWLYPLVP 290 DRSPVLKCTA 300 GAYMFPDTML 310 QAAGCFVGVV 320 LSSELPEDDR 330 ELFEDLLRQM 340 SDLRLQANWN 350 RAEEENEFQI 360 PGRTRPSSDQ 370 LKEASGTDVK 380 QLDQGNKDVR 390 HKGKRGKRAK 400 DTSSEEVNLS 410 HIVPCEPVPE 420 EKPKELPEWS 430 EKVAHNILSG 440 ASWVSWGLVK 450 GAEITGKAIQ 460 KGASKLRERI 470 QPEEKPVEVS 480 PAVTKGLYIA 490 KQATGGAAKV 500 SQFLVDGVCT 510 VANCVGKELA 520 PHVKKHGSKL 530 VPESLKKDKD 540 GKSPLDGAMV 550 VAASSVQGFS 560 TVWQGLECAA 570 KCIVNNVSAE 580 TVQTVRYKYG 590 YNAGEATHHA 600 VDSAVNVGVT 610 AYNINNIGIK 620 AMVKKTATQT 630 GHTLLEDYQI 640 VDNSQRENQE 650 GAANVNVRGE 660 KDEQTKEVKE AKKKDK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005811 lipid droplet
Cellular Component GO:0030496 midbody
Cellular Component GO:0005741 mitochondrial outer membrane
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0045202 synapse
Molecular Function GO:0008289 lipid binding
Molecular Function GO:0031625 ubiquitin protein ligase binding
Biological Process GO:0051301 cell division
Biological Process GO:0016042 lipid catabolic process
Biological Process GO:0006869 lipid transport
Biological Process GO:0061724 lipophagy
Biological Process GO:0061952 midbody abscission
Biological Process GO:0030514 negative regulation of BMP signaling pathway
Biological Process GO:0051881 regulation of mitochondrial membrane potential

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.