Search Results
Overview
| Uniprot ID | Q8N108 |
|---|---|
| Protein Name | Mesoderm induction early response protein 1 |
| Gene Name | MIER1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 349 | QTRFGKKKYNLHPGV |
| 434 | NGPTGGNKKPLHADM |
| 435 | GPTGGNKKPLHADMD |
| 471 | NENDFDEKSERPAKR |
| 486 | RRVNSNGKESPGSSE |
Function
Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing
Protein Sequence
10
MAEPSVESSS
20
PGGSATSDDH
30
EFDPSADMLV
40
HDFDDERTLE
50
EEEMMEGETN
60
FSSEIEDLAR
70
EGDMPIHELL
80
SLYGYGSTVR
90
LPEEDEEEEE
100
EEEEGEDDED
110
ADNDDNSGCS
120
GENKEENIKD
130
SSGQEDETQS
140
SNDDPSQSVA
150
SQDAQEIIRP
160
RRCKYFDTNS
170
EVEEESEEDE
180
DYIPSEDWKK
190
EIMVGSMFQA
200
EIPVGICRYK
210
ENEKVYENDD
220
QLLWDPEYLP
230
EDKVIIFLKD
240
ASRRTGDEKG
250
VEAIPEGSHI
260
KDNEQALYEL
270
VKCNFDTEEA
280
LRRLRFNVKA
290
AREELSVWTE
300
EECRNFEQGL
310
KAYGKDFHLI
320
QANKVRTRSV
330
GECVAFYYMW
340
KKSERYDFFA
350
QQTRFGKKKY
360
NLHPGVTDYM
370
DRLLDESESA
380
ASSRAPSPPP
390
TASNSSNSQS
400
EKEDGTVSTA
410
NQNGVSSNGP
420
GEILNKEEVK
430
VEGLHINGPT
440
GGNKKPLHAD
450
MDTNGYETDN
460
LTTDPKLAHM
470
TARNENDFDE
480
KSERPAKRRR
490
VNSNGKESPG
500
SSEFFQEAVS
510
HGKFEELENT
DD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0017053 | transcription repressor complex |
| Molecular Function | GO:0042826 | histone deacetylase binding |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Biological Process | GO:0006338 | chromatin remodeling |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0043123 | positive regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.