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Overview

Uniprot ID	Q8N142
Protein Name	Adenylosuccinate synthetase isozyme 1
Gene Name	ADSS1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
158	QRQAQEGKNIGTTKK
174	IGPTYSSKAARTGLR
18	PPGAGGVKRGRLQQE

Function

Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP

Protein Sequence

10 MSGTRASNDR 20 PPGAGGVKRG 30 RLQQEAAATG 40 SRVTVVLGAQ 50 WGDEGKGKVV 60 DLLATDADII 70 SRCQGGNNAG 80 HTVVVDGKEY 90 DFHLLPSGII 100 NTKAVSFIGN 110 GVVIHLPGLF 120 EEAEKNEKKG 130 LKDWEKRLII 140 SDRAHLVFDF 150 HQAVDGLQEV 160 QRQAQEGKNI 170 GTTKKGIGPT 180 YSSKAARTGL 190 RICDLLSDFD 200 EFSSRFKNLA 210 HQHQSMFPTL 220 EIDIEGQLKR 230 LKGFAERIRP 240 MVRDGVYFMY 250 EALHGPPKKI 260 LVEGANAALL 270 DIDFGTYPFV 280 TSSNCTVGGV 290 CTGLGIPPQN 300 IGDVYGVVKA 310 YTTRVGIGAF 320 PTEQINEIGG 330 LLQTRGHEWG 340 VTTGRKRRCG 350 WLDLMILRYA 360 HMVNGFTALA 370 LTKLDILDVL 380 GEVKVGVSYK 390 LNGKRIPYFP 400 ANQEMLQKVE 410 VEYETLPGWK 420 ADTTGARRWE 430 DLPPQAQNYI 440 RFVENHVGVA 450 VKWVGVGKSR ESMIQLF

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Molecular Function	GO:0004019	adenylosuccinate synthase activity
Molecular Function	GO:0005525	GTP binding
Molecular Function	GO:0000287	magnesium ion binding
Molecular Function	GO:0042301	phosphate ion binding
Biological Process	GO:0044208	'de novo' AMP biosynthetic process
Biological Process	GO:0006167	AMP biosynthetic process
Biological Process	GO:0044209	AMP salvage
Biological Process	GO:0002376	immune system process
Biological Process	GO:0046040	IMP metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.