Search Results

Overview

Uniprot IDQ8N1G0
Protein NameZinc finger protein 687
Gene NameZNF687
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1166 KKRRGVGKASALGLG
336 KVRIKTIKTSCGNIT
422 MAASVARKAVVLPGG
439 TSPKMIAKNVLGLVP
451 LVPQALPKADGRAGL
951 PRRELGSKGLKGGGG

Function

May be involved in transcriptional regulation

Protein Sequence

10 MGDMKTPDFD 20 DLLAAFDIPD 30 IDANEAIHSG 40 PEENEGPGGP 50 GKPEPGVGSE 60 SEDTAAASAG 70 DGPGVPAQAS 80 DHGLPPPDIS 90 VVSVIVKNTV 100 CPEQSEALAG 110 GSAGDGAQAA 120 GVTKEGPVGP 130 HRMQNGFGSP 140 EPSLPGTPHS 150 PAPPSGGTWK 160 EKGMEGKTPL 170 DLFAHFGPEP 180 GDHSDPLPPS 190 APSPTREGAL 200 TPPPFPSSFE 210 LAQENGPGMQ 220 PPVSSPPLGA 230 LKQESCSPHH 240 PQVLAQQGSG 250 SSPKATDIPA 260 SASPPPVAGV 270 PFFKQSPGHQ 280 SPLASPKVPV 290 CQPLKEEDDD 300 EGPVDKSSPG 310 SPQSPSSGAE 320 AADEDSNDSP 330 ASSSSRPLKV 340 RIKTIKTSCG 350 NITRTVTQVP 360 SDPDPPAPLA 370 EGAFLAEASL 380 LKLSPATPTS 390 EGPKVVSVQL 400 GDGTRLKGTV 410 LPVATIQNAS 420 TAMLMAASVA 430 RKAVVLPGGT 440 ATSPKMIAKN 450 VLGLVPQALP 460 KADGRAGLGT 470 GGQKVNGASV 480 VMVQPSKTAT 490 GPSTGGGTVI 500 SRTQSSLVEA 510 FNKILNSKNL 520 LPAYRPNLSP 530 PAEAGLALPP 540 TGYRCLECGD 550 AFSLEKSLAR 560 HYDRRSMRIE 570 VTCNHCARRL 580 VFFNKCSLLL 590 HAREHKDKGL 600 VMQCSHLVMR 610 PVALDQMVGQ 620 PDITPLLPVA 630 VPPVSGPLAL 640 PALGKGEGAI 650 TSSAITTVAA 660 EAPVLPLSTE 670 PPAAPATSAY 680 TCFRCLECKE 690 QCRDKAGMAA 700 HFQQLGPPAP 710 GATSNVCPTC 720 PMMLPNRCSF 730 SAHQRMHKNR 740 PPHVCPECGG 750 NFLQANFQTH 760 LREACLHVSR 770 RVGYRCPSCS 780 VVFGGVNSIK 790 SHIQTSHCEV 800 FHKCPICPMA 810 FKSGPSAHAH 820 LYSQHPSFQT 830 QQAKLIYKCA 840 MCDTVFTHKP 850 LLSSHFDQHL 860 LPQRVSVFKC 870 PSCPLLFAQK 880 RTMLEHLKNT 890 HQSGRLEETA 900 GKGAGGALLT 910 PKTEPEELAV 920 SQGGAAPATE 930 ESSSSSEEEE 940 VPSSPEPPRP 950 AKRPRRELGS 960 KGLKGGGGGP 970 GGWTCGLCHS 980 WFPERDEYVA 990 HMKKEHGKSV 1000 KKFPCRLCER 1010 SFCSAPSLRR 1020 HVRVNHEGIK 1030 RVYPCRYCTE 1040 GKRTFSSRLI 1050 LEKHVQVRHG 1060 LQLGAQSPGR 1070 GTTLARGSSA 1080 RAQGPGRKRR 1090 QSSDSCSEEP 1100 DSTTPPAKSP 1110 RGGPGSGGHG 1120 PLRYRSSSST 1130 EQSLMMGLRV 1140 EDGAQQCLDC 1150 GLCFASPGSL 1160 SRHRFISHKK 1170 RRGVGKASAL 1180 GLGDGEEEAP 1190 PSRSDPDGGD 1200 SPLPASGGPL 1210 TCKVCGKSCD 1220 SPLNLKTHFR 1230 THGMAFIRAR QGAVGDN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0003700 DNA-binding transcription factor activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.