Search Results

Overview

Uniprot IDQ8N1G2
Protein NameCap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Gene NameCMTR1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
108 REGEGLGKYSQGRKD
114 GKYSQGRKDIVEASS
123 IVEASSQKGRRGLGL
14 PECTAPIKKQKKRVA
15 ECTAPIKKQKKRVAE
650 HELKGEGKAQRKISA
725 RLEMKIIKGSSGTPK
764 PWTMGFSKSFKKKFF
767 MGFSKSFKKKFFYNK
93 MYNSVSQKLMAKMGF
97 VSQKLMAKMGFREGE

Function

S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway

Protein Sequence

10 MKRRTDPECT 20 APIKKQKKRV 30 AELALSLSST 40 SDDEPPSSVS 50 HGAKASTTSL 60 SGSDSETEGK 70 QHSSDSFDDA 80 FKADSLVEGT 90 SSRYSMYNSV 100 SQKLMAKMGF 110 REGEGLGKYS 120 QGRKDIVEAS 130 SQKGRRGLGL 140 TLRGFDQELN 150 VDWRDEPEPS 160 ACEQVSWFPE 170 CTTEIPDTQE 180 MSDWMVVGKR 190 KMIIEDETEF 200 CGEELLHSVL 210 QCKSVFDVLD 220 GEEMRRARTR 230 ANPYEMIRGV 240 FFLNRAAMKM 250 ANMDFVFDRM 260 FTNPRDSYGK 270 PLVKDREAEL 280 LYFADVCAGP 290 GGFSEYVLWR 300 KKWHAKGFGM 310 TLKGPNDFKL 320 EDFYSASSEL 330 FEPYYGEGGI 340 DGDGDITRPE 350 NISAFRNFVL 360 DNTDRKGVHF 370 LMADGGFSVE 380 GQENLQEILS 390 KQLLLCQFLM 400 ALSIVRTGGH 410 FICKTFDLFT 420 PFSVGLVYLL 430 YCCFERVCLF 440 KPITSRPANS 450 ERYVVCKGLK 460 VGIDDVRDYL 470 FAVNIKLNQL 480 RNTDSDVNLV 490 VPLEVIKGDH 500 EFTDYMIRSN 510 ESHCSLQIKA 520 LAKIHAFVQD 530 TTLSEPRQAE 540 IRKECLRLWG 550 IPDQARVAPS 560 SSDPKSKFFE 570 LIQGTEIDIF 580 SYKPTLLTSK 590 TLEKIRPVFD 600 YRCMVSGSEQ 610 KFLIGLGKSQ 620 IYTWDGRQSD 630 RWIKLDLKTE 640 LPRDTLLSVE 650 IVHELKGEGK 660 AQRKISAIHI 670 LDVLVLNGTD 680 VREQHFNQRI 690 QLAEKFVKAV 700 SKPSRPDMNP 710 IRVKEVYRLE 720 EMEKIFVRLE 730 MKIIKGSSGT 740 PKLSYTGRDD 750 RHFVPMGLYI 760 VRTVNEPWTM 770 GFSKSFKKKF 780 FYNKKTKDST 790 FDLPADSIAP 800 FHICYYGRLF 810 WEWGDGIRVH 820 DSQKPQDQDK 830 LSKEDVLSFI QMHRA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0004483 methyltransferase cap1 activity
Molecular Function GO:0003676 nucleic acid binding
Biological Process GO:0006370 7-methylguanosine mRNA capping
Biological Process GO:0032259 methylation
Biological Process GO:0006397 mRNA processing

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[5] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[6] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[7] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[8] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.