Search Results
Overview
| Uniprot ID | Q8N1V2 |
|---|---|
| Protein Name | Cilia- and flagella-associated protein 52 |
| Gene Name | CFAP52 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 387 | IDFMRDGKSIISAWN |
Function
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme (PubMed:36191189). Important for proper ciliary and flagellar beating. May act in cooperation with CFAP45 and axonemal dynein subunit DNAH11 (PubMed:33139725). May play a role in cell growth and/or survival (PubMed:15967112)
Protein Sequence
10
MDNKISPEAQ
20
VAELELDAVI
30
GFNGHVPTGL
40
KCHPDQEHMI
50
YPLGCTVLIQ
60
AINTKEQNFL
70
QGHGNNVSCL
80
AISRSGEYIA
90
SGQVTFMGFK
100
ADIILWDYKN
110
RELLARLSLH
120
KGKIEALAFS
130
PNDLYLVSLG
140
GPDDGSVVVW
150
SIAKRDAICG
160
SPAAGLNVGN
170
ATNVIFSRCR
180
DEMFMTAGNG
190
TIRVWELDLP
200
NRKIWPTECQ
210
TGQLKRIVMS
220
IGVDDDDSFF
230
YLGTTTGDIL
240
KMNPRTKLLT
250
DVGPAKDKFS
260
LGVSAIRCLK
270
MGGLLVGSGA
280
GLLVFCKSPG
290
YKPIKKIQLQ
300
GGITSITLRG
310
EGHQFLVGTE
320
ESHIYRVSFT
330
DFKETLIATC
340
HFDAVEDIVF
350
PFGTAELFAT
360
CAKKDIRVWH
370
TSSNRELLRI
380
TVPNMTCHGI
390
DFMRDGKSII
400
SAWNDGKIRA
410
FAPETGRLMY
420
VINNAHRIGV
430
TAIATTSDCK
440
RVISGGGEGE
450
VRVWQIGCQT
460
QKLEEALKEH
470
KSSVSCIRVK
480
RNNEECVTAS
490
TDGTCIIWDL
500
VRLRRNQMIL
510
ANTLFQCVCY
520
HPEEFQIITS
530
GTDRKIAYWE
540
VFDGTVIREL
550
EGSLSGSING
560
MDITQEGVHF
570
VTGGNDHLVK
580
VWDYNEGEVT
590
HVGVGHSGNI
600
TRIRISPGNQ
610
YIVSVSADGA
620
ILRWKYPYTS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0097729 | 9+2 motile cilium |
| Cellular Component | GO:0160112 | axonemal B tubule inner sheath |
| Cellular Component | GO:0005879 | axonemal microtubule |
| Cellular Component | GO:0005930 | axoneme |
| Cellular Component | GO:0036126 | sperm flagellum |
| Cellular Component | GO:0097225 | sperm midpiece |
| Biological Process | GO:0061966 | establishment of left/right asymmetry |
| Biological Process | GO:0030317 | flagellated sperm motility |
Reference
[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.