Overview
| Uniprot ID | Q8N205 |
|---|
| Protein Name | Nesprin-4 |
|---|
| Gene Name | SYNE4 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 309 |
ESGLGHQKRLARHQR |
Function
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus (By similarity)
Protein Sequence
10
MALSLPLGPR
20
LGSEPLNHPP
30
GAPREADIVG
40
CTVCPASGEE
50
STSPEQAQTL
60
GQDSLGPPEH
70
FQGGPRGNEP
80
AAHPPRWSTP
90
SSYEDPAGGK
100
HCEHPISGLE
110
VLEAEQNSLH
120
LCLLGLGRRL
130
QDLEQGLGHW
140
ALAQSGMVQL
150
QALQVDLRGA
160
AERVEALLAF
170
GEGLAQRSEP
180
RAWAALEQIL
190
RALGAYRDSI
200
FRRLWQLQAQ
210
LVSYSLVFEE
220
ANTLDQDLEV
230
EGDSDWPGPG
240
GVWGPWAPSS
250
LPTSTELEWD
260
PAGDIGGLGP
270
LGQKTARTLG
280
VPCELCGQRG
290
PQGRGQGLEE
300
ADTSHSRQDM
310
LESGLGHQKR
320
LARHQRHSLL
330
RKPQDKKRQA
340
SPHLQDVRLE
350
GNPGAPDPAS
360
RQPLTFLLIL
370
FLLFLLLVGA
380
MFLLPASGGP
390
CCSHARIPRT
400
PYLVLSYVNG
LPPV
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0034993 |
meiotic nuclear membrane microtubule tethering complex |
| Cellular Component |
GO:0005640 |
nuclear outer membrane |
| Biological Process |
GO:0045198 |
establishment of epithelial cell apical/basal polarity |
Reference
[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.