Search Results

Overview

Uniprot IDQ8N2C7
Protein NameProtein unc-80 homolog
Gene NameUNC80
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
770 GGGGPYEKNDKNQEK

Function

Auxilary subunit of the NALCN channelosome complex, which regulates the resting membrane potential by depolarizing sodium leak currents (PubMed:32494638, PubMed:35387979, PubMed:34929720). The NALCN channelosome complex is a voltage-gated ion channel responsible for the resting Na(+) permeability that controls neuronal excitability (PubMed:35387979, PubMed:34929720). The NALCN channelosome is constitutively active and conducts monovalent cations but is blocked by physiological concentrations of extracellular divalent cations (PubMed:32494638). Activated by neuropeptides substance P, neurotensin, and extracellular Ca(2+) that regulates neuronal excitability by controlling the sizes of NALCN-dependent sodium-leak current (PubMed:32494638). UNC80 is also essential for NALCN sensitivity to extracellular Ca(2+) (PubMed:32494638)

Protein Sequence

10 MVKRKSSEGQ 20 EQDGGRGIPL 30 PIQTFLWRQT 40 SAFLRPKLGK 50 QYEASCVSFE 60 RVLVENKLHG 70 LSPALSEAIQ 80 SISRWELVQA 90 ALPHVLHCTA 100 TLLSNRNKLG 110 HQDKLGVAET 120 KLLHTLHWML 130 LEAPQDCNNE 140 RFGGTDRGSS 150 WGGSSSAFIH 160 QVENQGSPGQ 170 PCQSSSNDEE 180 ENNRRKIFQN 190 SMATVELFVF 200 LFAPLVHRIK 210 ESDLTFRLAS 220 GLVIWQPMWE 230 HRQPGVSGFT 240 ALVKPIRNII 250 TAKRSSPINS 260 QSRTCESPNQ 270 DARHLEGLQV 280 VCETFQSDSI 290 SPKATISGCH 300 RGNSFDGSLS 310 SQTSQERGPS 320 HSRASLVIPP 330 CQRSRYATYF 340 DVAVLRCLLQ 350 PHWSEEGTQW 360 SLMYYLQRLR 370 HMLEEKPEKP 380 PEPDIPLLPR 390 PRSSSMVAAA 400 PSLVNTHKTQ 410 DLTMKCNEEE 420 KSLSSEAFSK 430 VSLTNLRRSA 440 VPDLSSDLGM 450 NIFKKFKSRK 460 EDRERKGSIP 470 FHHTGKRRPR 480 RMGVPFLLHE 490 DHLDVSPTRS 500 TFSFGSFSGL 510 GEDRRGIEKG 520 GWQTTILGKL 530 TRRGSSDAAT 540 EMESLSARHS 550 HSHHTLVSDL 560 PDPSNSHGEN 570 TVKEVRSQIS 580 TITVATFNTT 590 LASFNVGYAD 600 FFNEHMRKLC 610 NQVPIPEMPH 620 EPLACANLPR 630 SLTDSCINYS 640 YLEDTEHIDG 650 TNNFVHKNGM 660 LDLSVVLKAV 670 YLVLNHDISS 680 RICDVALNIV 690 ECLLQLGVVP 700 CVEKNRKKSE 710 NKENETLEKR 720 PSEGAFQFKG 730 VSGSSTCGFG 740 GPAVSGAGDG 750 GGEEGGGGDG 760 GGGGGDGGGG 770 GGGGGGPYEK 780 NDKNQEKDES 790 TPVSNHRLAL 800 TMLIKIVKSL 810 GCAYGCGEGH 820 RGLSGDRLRH 830 QVFRENAQNC 840 LTKLYKLDKM 850 QFRQTMRDYV 860 NKDSLNNVVD 870 FLHALLGFCM 880 EPVTDNKAGF 890 GNNFTTVDNK 900 STAQNVEGII 910 VSAMFKSLIT 920 RCASTTHELH 930 SPENLGLYCD 940 IRQLVQFIKE 950 AHGNVFRRVA 960 LSALLDSAEK 970 LAPGKKVEEN 980 EQESKPAGSK 990 RSEAGSIVDK 1000 GQVSSAPEEC 1010 RSFMSGRPSQ 1020 TPEHDEQMQG 1030 ANLGRKDFWR 1040 KMFKSQSAAS 1050 DTSSQSEQDT 1060 SECTTAHSGT 1070 TSDRRARSRS 1080 RRISLRKKLK 1090 LPIGKRNWLK 1100 RSSLSGLADG 1110 VEDLLDISSV 1120 DRLSFIRQSS 1130 KVKFTSAVKL 1140 SEGGPGSGME 1150 NGRDEEENFF 1160 KRLGCHSFDD 1170 HLSPNQDGGK 1180 SKNVVNLGAI 1190 RQGMKRFQFL 1200 LNCCEPGTIP 1210 DASILAAALD 1220 LEAPVVARAA 1230 LFLECARFVH 1240 RCNRGNWPEW 1250 MKGHHVNITK 1260 KGLSRGRSPI 1270 VGNKRNQKLQ 1280 WNAAKLFYQW 1290 GDAIGVRLNE 1300 LCHGESESPA 1310 NLLGLIYDEE 1320 TKRRLRKEDE 1330 EEDFLDDSTV 1340 NPSKCGCPFA 1350 LKMAACQLLL 1360 EITTFLRETF 1370 SCLPRPRTEP 1380 LVDLESCRLR 1390 LDPELDRHRY 1400 ERKISFAGVL 1410 DENEDSKDSL 1420 HSSSHTLKSD 1430 AGVEEKKEGS 1440 PWSASEPSIE 1450 PEGMSNAGAE 1460 ENYHRNMSWL 1470 HVMILLCNQQ 1480 SFICTHVDYC 1490 HPHCYLHHSR 1500 SCARLVRAIK 1510 LLYGDSVDSL 1520 RESSNISSVA 1530 LRGKKQKECS 1540 DKSCLRTPSL 1550 KKRVSDANLE 1560 GKKDSGMLKY 1570 IRLQVMSLSP 1580 APLSLLIKAA 1590 PILTEEMYGD 1600 IQPAAWELLL 1610 SMDEHMAGAA 1620 AAMFLLCAVK 1630 VPEAVSDMLM 1640 SEFHHPETVQ 1650 RLNAVLKFHT 1660 LWRFRYQVWP 1670 RMEEGAQQIF 1680 KIPPPSINFT 1690 LPSPVLGMPS 1700 VPMFDPPWVP 1710 QCSGSVQDPI 1720 NEDQSKSFSA 1730 RAVSRSHQRA 1740 EHILKNLQQE 1750 EEKKRLGREA 1760 SLITAIPITQ 1770 EACYEPTCTP 1780 NSEPEEEVEE 1790 VTNLASRRLS 1800 VSPSCTSSTS 1810 HRNYSFRRGS 1820 VWSVRSAVSA 1830 EDEEHTTEHT 1840 PNHHVPQPPQ 1850 AVFPACICAA 1860 VLPIVHLMED 1870 GEVREDGVAV 1880 SAVAQQVLWN 1890 CLIEDPSTVL 1900 RHFLEKLTIS 1910 NRQDELMYML 1920 RKLLLNIGDF 1930 PAQTSHILFN 1940 YLVGLIMYFV 1950 RTPCEWGMDA 1960 ISATLTFLWE 1970 VVGYVEGLFF 1980 KDLKQTMKKE 1990 QCEVKLLVTA 2000 SMPGTKTLVV 2010 HGQNECDIPT 2020 QLPVHEDTQF 2030 EALLKECLEF 2040 FNIPESQSTH 2050 YFLMDKRWNL 2060 IHYNKTYVRD 2070 IYPFRRSVSP 2080 QLNLVHMHPE 2090 KGQELIQKQV 2100 FTRKLEEVGR 2110 VLFLISLTQK 2120 IPTAHKQSHV 2130 SMLQEDLLRL 2140 PSFPRSAIDA 2150 EFSLFSDPQA 2160 GKELFGLDTL 2170 QKSLWIQLLE 2180 EMFLGMPSEF 2190 PWGDEIMLFL 2200 NVFNGALILH 2210 PEDSALLRQY 2220 AATVINTAVH 2230 FNHLFSLSGY 2240 QWILPTMLQV 2250 YSDYESNPQL 2260 RQAIEFACHQ 2270 FYILHRKPFV 2280 LQLFASVAPL 2290 LEFPDAANNG 2300 PSKGVSAQCL 2310 FDLLQSLEGE 2320 TTDILDILEL 2330 VKAEKPLKSL 2340 DFCYGNEDLT 2350 FSISEAIKLC 2360 VTVVAYAPES 2370 FRSLQMLMVL 2380 EALVPCYLQK 2390 LKRQTSQVET 2400 VPAAREEIAA 2410 TAALATSLQA 2420 LLYSVEVLTR 2430 PMTAPQMSRC 2440 DQGHKGTTTA 2450 NHTMSSGVNT 2460 RYQEQGAKLH 2470 FIRENLHLLE 2480 EGQGIPREEL 2490 DERIAREEFR 2500 RPRESLLNIC 2510 TEFYKHCGPR 2520 LKILQNLAGE 2530 PRVIALELLD 2540 VKSHMRLAEI 2550 AHSLLKLAPY 2560 DTQTMESRGL 2570 RRYIMEMLPI 2580 TDWTAEAVRP 2590 ALILILKRLD 2600 RMFNKIHKMP 2610 TLRRQVEWEP 2620 ASNLIEGVCL 2630 TLQRQPIISF 2640 LPHLRSLINV 2650 CVNLVMGVVG 2660 PSSVADGLPL 2670 LHLSPYLSPP 2680 LPFSTAVVRL 2690 VALQIQALKE 2700 DFPLSHVISP 2710 FTNQERREGM 2720 LLNLLIPFVL 2730 TVGSGSKDSP 2740 WLEQPEVQLL 2750 LQTVINVLLP 2760 PRIISTSRSK 2770 NFMLESSPAH 2780 CSTPGDAGKD 2790 LRREGLAEST 2800 SQAAYLALKV 2810 ILVCFERQLG 2820 SQWYWLSLQV 2830 KEMALRKVGG 2840 LALWDFLDFI 2850 VRTRIPIFVL 2860 LRPFIQCKLL 2870 AQPAENHEEL 2880 SARQHIADQL 2890 ERRFIPRPLC 2900 KSSLIAEFNS 2910 ELKILKEAVH 2920 SGSAYQGKTS 2930 ISTVGTSTSA 2940 YRLSLATMSR 2950 SNTGTGTVWE 2960 QDSEPSQQAS 2970 QDTLSRTDEE 2980 DEENDSISMP 2990 SVVSEQEAYL 3000 LSAIGRRRFS 3010 SHVSSMSVPQ 3020 AEVGMLPSQS 3030 EPNVLDDSQG 3040 LAAEGSLSRV 3050 ASIQSEPGQQ 3060 NLLVQQPLGR 3070 KRGLRQLRRP 3080 LLSRQKTQTE 3090 PRNRQGARLS 3100 TTRRSIQPKT 3110 KPSADQKRSV 3120 TFIEAQPEPA 3130 AAPTDALPAT 3140 GQLQGCSPAP 3150 SRKPEAMDEP 3160 VLTSSPAIVV 3170 ADLHSVSPKQ 3180 SENFPTEEGE 3190 KEEDTEAQGA 3200 TAHSPLSAQL 3210 SDPDDFTGLE 3220 TSSLLQHGDT 3230 VLHISEENGM 3240 ENPLLSSQFT 3250 FTPTELGKTD AVLDESHV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0034703 cation channel complex
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0030424 axon
Molecular Function GO:0005261 monoatomic cation channel activity
Biological Process GO:0055080 monoatomic cation homeostasis
Biological Process GO:0098908 regulation of neuronal action potential
Biological Process GO:0035725 sodium ion transmembrane transport

Reference

PMID: N/A