Overview
| Uniprot ID | Q8N2C7 |
| Protein Name | Protein unc-80 homolog |
| Gene Name | UNC80 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 770 |
GGGGPYEKNDKNQEK |
Function
Auxilary subunit of the NALCN channelosome complex, which regulates the resting membrane potential by depolarizing sodium leak currents (PubMed:32494638, PubMed:35387979, PubMed:34929720). The NALCN channelosome complex is a voltage-gated ion channel responsible for the resting Na(+) permeability that controls neuronal excitability (PubMed:35387979, PubMed:34929720). The NALCN channelosome is constitutively active and conducts monovalent cations but is blocked by physiological concentrations of extracellular divalent cations (PubMed:32494638). Activated by neuropeptides substance P, neurotensin, and extracellular Ca(2+) that regulates neuronal excitability by controlling the sizes of NALCN-dependent sodium-leak current (PubMed:32494638). UNC80 is also essential for NALCN sensitivity to extracellular Ca(2+) (PubMed:32494638)
Protein Sequence
10
MVKRKSSEGQ
20
EQDGGRGIPL
30
PIQTFLWRQT
40
SAFLRPKLGK
50
QYEASCVSFE
60
RVLVENKLHG
70
LSPALSEAIQ
80
SISRWELVQA
90
ALPHVLHCTA
100
TLLSNRNKLG
110
HQDKLGVAET
120
KLLHTLHWML
130
LEAPQDCNNE
140
RFGGTDRGSS
150
WGGSSSAFIH
160
QVENQGSPGQ
170
PCQSSSNDEE
180
ENNRRKIFQN
190
SMATVELFVF
200
LFAPLVHRIK
210
ESDLTFRLAS
220
GLVIWQPMWE
230
HRQPGVSGFT
240
ALVKPIRNII
250
TAKRSSPINS
260
QSRTCESPNQ
270
DARHLEGLQV
280
VCETFQSDSI
290
SPKATISGCH
300
RGNSFDGSLS
310
SQTSQERGPS
320
HSRASLVIPP
330
CQRSRYATYF
340
DVAVLRCLLQ
350
PHWSEEGTQW
360
SLMYYLQRLR
370
HMLEEKPEKP
380
PEPDIPLLPR
390
PRSSSMVAAA
400
PSLVNTHKTQ
410
DLTMKCNEEE
420
KSLSSEAFSK
430
VSLTNLRRSA
440
VPDLSSDLGM
450
NIFKKFKSRK
460
EDRERKGSIP
470
FHHTGKRRPR
480
RMGVPFLLHE
490
DHLDVSPTRS
500
TFSFGSFSGL
510
GEDRRGIEKG
520
GWQTTILGKL
530
TRRGSSDAAT
540
EMESLSARHS
550
HSHHTLVSDL
560
PDPSNSHGEN
570
TVKEVRSQIS
580
TITVATFNTT
590
LASFNVGYAD
600
FFNEHMRKLC
610
NQVPIPEMPH
620
EPLACANLPR
630
SLTDSCINYS
640
YLEDTEHIDG
650
TNNFVHKNGM
660
LDLSVVLKAV
670
YLVLNHDISS
680
RICDVALNIV
690
ECLLQLGVVP
700
CVEKNRKKSE
710
NKENETLEKR
720
PSEGAFQFKG
730
VSGSSTCGFG
740
GPAVSGAGDG
750
GGEEGGGGDG
760
GGGGGDGGGG
770
GGGGGGPYEK
780
NDKNQEKDES
790
TPVSNHRLAL
800
TMLIKIVKSL
810
GCAYGCGEGH
820
RGLSGDRLRH
830
QVFRENAQNC
840
LTKLYKLDKM
850
QFRQTMRDYV
860
NKDSLNNVVD
870
FLHALLGFCM
880
EPVTDNKAGF
890
GNNFTTVDNK
900
STAQNVEGII
910
VSAMFKSLIT
920
RCASTTHELH
930
SPENLGLYCD
940
IRQLVQFIKE
950
AHGNVFRRVA
960
LSALLDSAEK
970
LAPGKKVEEN
980
EQESKPAGSK
990
RSEAGSIVDK
1000
GQVSSAPEEC
1010
RSFMSGRPSQ
1020
TPEHDEQMQG
1030
ANLGRKDFWR
1040
KMFKSQSAAS
1050
DTSSQSEQDT
1060
SECTTAHSGT
1070
TSDRRARSRS
1080
RRISLRKKLK
1090
LPIGKRNWLK
1100
RSSLSGLADG
1110
VEDLLDISSV
1120
DRLSFIRQSS
1130
KVKFTSAVKL
1140
SEGGPGSGME
1150
NGRDEEENFF
1160
KRLGCHSFDD
1170
HLSPNQDGGK
1180
SKNVVNLGAI
1190
RQGMKRFQFL
1200
LNCCEPGTIP
1210
DASILAAALD
1220
LEAPVVARAA
1230
LFLECARFVH
1240
RCNRGNWPEW
1250
MKGHHVNITK
1260
KGLSRGRSPI
1270
VGNKRNQKLQ
1280
WNAAKLFYQW
1290
GDAIGVRLNE
1300
LCHGESESPA
1310
NLLGLIYDEE
1320
TKRRLRKEDE
1330
EEDFLDDSTV
1340
NPSKCGCPFA
1350
LKMAACQLLL
1360
EITTFLRETF
1370
SCLPRPRTEP
1380
LVDLESCRLR
1390
LDPELDRHRY
1400
ERKISFAGVL
1410
DENEDSKDSL
1420
HSSSHTLKSD
1430
AGVEEKKEGS
1440
PWSASEPSIE
1450
PEGMSNAGAE
1460
ENYHRNMSWL
1470
HVMILLCNQQ
1480
SFICTHVDYC
1490
HPHCYLHHSR
1500
SCARLVRAIK
1510
LLYGDSVDSL
1520
RESSNISSVA
1530
LRGKKQKECS
1540
DKSCLRTPSL
1550
KKRVSDANLE
1560
GKKDSGMLKY
1570
IRLQVMSLSP
1580
APLSLLIKAA
1590
PILTEEMYGD
1600
IQPAAWELLL
1610
SMDEHMAGAA
1620
AAMFLLCAVK
1630
VPEAVSDMLM
1640
SEFHHPETVQ
1650
RLNAVLKFHT
1660
LWRFRYQVWP
1670
RMEEGAQQIF
1680
KIPPPSINFT
1690
LPSPVLGMPS
1700
VPMFDPPWVP
1710
QCSGSVQDPI
1720
NEDQSKSFSA
1730
RAVSRSHQRA
1740
EHILKNLQQE
1750
EEKKRLGREA
1760
SLITAIPITQ
1770
EACYEPTCTP
1780
NSEPEEEVEE
1790
VTNLASRRLS
1800
VSPSCTSSTS
1810
HRNYSFRRGS
1820
VWSVRSAVSA
1830
EDEEHTTEHT
1840
PNHHVPQPPQ
1850
AVFPACICAA
1860
VLPIVHLMED
1870
GEVREDGVAV
1880
SAVAQQVLWN
1890
CLIEDPSTVL
1900
RHFLEKLTIS
1910
NRQDELMYML
1920
RKLLLNIGDF
1930
PAQTSHILFN
1940
YLVGLIMYFV
1950
RTPCEWGMDA
1960
ISATLTFLWE
1970
VVGYVEGLFF
1980
KDLKQTMKKE
1990
QCEVKLLVTA
2000
SMPGTKTLVV
2010
HGQNECDIPT
2020
QLPVHEDTQF
2030
EALLKECLEF
2040
FNIPESQSTH
2050
YFLMDKRWNL
2060
IHYNKTYVRD
2070
IYPFRRSVSP
2080
QLNLVHMHPE
2090
KGQELIQKQV
2100
FTRKLEEVGR
2110
VLFLISLTQK
2120
IPTAHKQSHV
2130
SMLQEDLLRL
2140
PSFPRSAIDA
2150
EFSLFSDPQA
2160
GKELFGLDTL
2170
QKSLWIQLLE
2180
EMFLGMPSEF
2190
PWGDEIMLFL
2200
NVFNGALILH
2210
PEDSALLRQY
2220
AATVINTAVH
2230
FNHLFSLSGY
2240
QWILPTMLQV
2250
YSDYESNPQL
2260
RQAIEFACHQ
2270
FYILHRKPFV
2280
LQLFASVAPL
2290
LEFPDAANNG
2300
PSKGVSAQCL
2310
FDLLQSLEGE
2320
TTDILDILEL
2330
VKAEKPLKSL
2340
DFCYGNEDLT
2350
FSISEAIKLC
2360
VTVVAYAPES
2370
FRSLQMLMVL
2380
EALVPCYLQK
2390
LKRQTSQVET
2400
VPAAREEIAA
2410
TAALATSLQA
2420
LLYSVEVLTR
2430
PMTAPQMSRC
2440
DQGHKGTTTA
2450
NHTMSSGVNT
2460
RYQEQGAKLH
2470
FIRENLHLLE
2480
EGQGIPREEL
2490
DERIAREEFR
2500
RPRESLLNIC
2510
TEFYKHCGPR
2520
LKILQNLAGE
2530
PRVIALELLD
2540
VKSHMRLAEI
2550
AHSLLKLAPY
2560
DTQTMESRGL
2570
RRYIMEMLPI
2580
TDWTAEAVRP
2590
ALILILKRLD
2600
RMFNKIHKMP
2610
TLRRQVEWEP
2620
ASNLIEGVCL
2630
TLQRQPIISF
2640
LPHLRSLINV
2650
CVNLVMGVVG
2660
PSSVADGLPL
2670
LHLSPYLSPP
2680
LPFSTAVVRL
2690
VALQIQALKE
2700
DFPLSHVISP
2710
FTNQERREGM
2720
LLNLLIPFVL
2730
TVGSGSKDSP
2740
WLEQPEVQLL
2750
LQTVINVLLP
2760
PRIISTSRSK
2770
NFMLESSPAH
2780
CSTPGDAGKD
2790
LRREGLAEST
2800
SQAAYLALKV
2810
ILVCFERQLG
2820
SQWYWLSLQV
2830
KEMALRKVGG
2840
LALWDFLDFI
2850
VRTRIPIFVL
2860
LRPFIQCKLL
2870
AQPAENHEEL
2880
SARQHIADQL
2890
ERRFIPRPLC
2900
KSSLIAEFNS
2910
ELKILKEAVH
2920
SGSAYQGKTS
2930
ISTVGTSTSA
2940
YRLSLATMSR
2950
SNTGTGTVWE
2960
QDSEPSQQAS
2970
QDTLSRTDEE
2980
DEENDSISMP
2990
SVVSEQEAYL
3000
LSAIGRRRFS
3010
SHVSSMSVPQ
3020
AEVGMLPSQS
3030
EPNVLDDSQG
3040
LAAEGSLSRV
3050
ASIQSEPGQQ
3060
NLLVQQPLGR
3070
KRGLRQLRRP
3080
LLSRQKTQTE
3090
PRNRQGARLS
3100
TTRRSIQPKT
3110
KPSADQKRSV
3120
TFIEAQPEPA
3130
AAPTDALPAT
3140
GQLQGCSPAP
3150
SRKPEAMDEP
3160
VLTSSPAIVV
3170
ADLHSVSPKQ
3180
SENFPTEEGE
3190
KEEDTEAQGA
3200
TAHSPLSAQL
3210
SDPDDFTGLE
3220
TSSLLQHGDT
3230
VLHISEENGM
3240
ENPLLSSQFT
3250
FTPTELGKTD
AVLDESHV
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0034703 |
cation channel complex |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0030424 |
axon |
| Molecular Function |
GO:0005261 |
monoatomic cation channel activity |
| Biological Process |
GO:0055080 |
monoatomic cation homeostasis |
| Biological Process |
GO:0098908 |
regulation of neuronal action potential |
| Biological Process |
GO:0035725 |
sodium ion transmembrane transport |
Reference
PMID: N/A