Search Results

Overview

Uniprot IDQ8N2M8
Protein NameCLK4-associating serine/arginine rich protein
Gene NameCLASRP
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
553 ASPAVGEKLKKTEPA
555 PAVGEKLKKTEPAAG
571 ETGAAKPKLTPQEKL

Function

Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity)

Protein Sequence

10 MWHEARKHER 20 KLRGMMVDYK 30 KRAERRREYY 40 EKIKKDPAQF 50 LQVHGRACKV 60 HLDSAVALAA 70 ESPVNMMPWQ 80 GDTNNMIDRF 90 DVRAHLDHIP 100 DYTPPLLTTI 110 SPEQESDERK 120 CNYERYRGLV 130 QNDFAGISEE 140 QCLYQIYIDE 150 LYGGLQRPSE 160 DEKKKLAEKK 170 ASIGYTYEDS 180 TVAEVEKAAE 190 KPEEEESAAE 200 EESNSDEDEV 210 IPDIDVEVDV 220 DELNQEQVAD 230 LNKQATTYGM 240 ADGDFVRMLR 250 KDKEEAEAIK 260 HAKALEEEKA 270 MYSGRRSRRQ 280 RREFREKRLR 290 GRKISPPSYA 300 RRDSPTYDPY 310 KRSPSESSSE 320 SRSRSRSPTP 330 GREEKITFIT 340 SFGGSDEEAA 350 AAAAAAAASG 360 VTTGKPPAPP 370 QPGGPAPGRN 380 ASARRRSSSS 390 SSSSSASRTS 400 SSRSSSRSSS 410 RSRRGGGYYR 420 SGRHARSRSR 430 SWSRSRSRSR 440 RYSRSRSRGR 450 RHSGGGSRDG 460 HRYSRSPARR 470 GGYGPRRRSR 480 SRSHSGDRYR 490 RGGRGLRHHS 500 SSRSRSSWSL 510 SPSRSRSLTR 520 SRSHSPSPSQ 530 SRSRSRSRSQ 540 SPSPSPAREK 550 LTRPAASPAV 560 GEKLKKTEPA 570 AGKETGAAKP 580 KLTPQEKLKL 590 RMQKALNRQF 600 KADKKAAQEK 610 MIQQEHERQE 620 REDELRAMAR 630 KIRMKERERR 640 EKEREEWERQ 650 YSRQSRSPSP 660 RYSREYSSSR 670 RRSRSRSRSP HYRH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Biological Process GO:0006397 mRNA processing
Biological Process GO:0008380 RNA splicing

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.