Overview
| Uniprot ID | Q8N300 |
|---|
| Protein Name | Small vasohibin-binding protein |
|---|
| Gene Name | SVBP |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 11 |
PARKEKTKVKESVSR |
| 7 |
*MDPPARKEKTKVKE |
| 9 |
DPPARKEKTKVKESV |
Function
Enhances the tyrosine carboxypeptidase activity of VASH1 and VASH2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin (PubMed:29146869, PubMed:31171830, PubMed:31235910, PubMed:31235911, PubMed:31270470, PubMed:31324789). This activity is critical for spindle function and accurate chromosome segregation during mitosis since microtubule detyrosination regulates mitotic spindle length and postioning (PubMed:31171830). Also required to enhance the solubility and secretion of VASH1 and VASH2 (PubMed:20736312, PubMed:27879017, PubMed:30607023). Plays a role in axon and excitatory synapse formation (PubMed:31235911)
Protein Sequence
10
MDPPARKEKT
20
KVKESVSRVE
30
KAKQKSAQQE
40
LKQRQRAEIY
50
ALNRVMTELE
60
QQQFDEFCKQ
MQPPGE
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0045177 |
apical part of cell |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005856 |
cytoskeleton |
| Cellular Component |
GO:0005576 |
extracellular region |
| Molecular Function |
GO:0008017 |
microtubule binding |
| Molecular Function |
GO:0016504 |
peptidase activator activity |
| Biological Process |
GO:0061564 |
axon development |
| Biological Process |
GO:0010596 |
negative regulation of endothelial cell migration |
| Biological Process |
GO:0031397 |
negative regulation of protein ubiquitination |
| Biological Process |
GO:0009306 |
protein secretion |
| Biological Process |
GO:0006508 |
proteolysis |
| Biological Process |
GO:1905048 |
regulation of metallopeptidase activity |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.