Search Results

Overview

Uniprot ID	Q8N302
Protein Name	Angiogenic factor with G patch and FHA domains 1
Gene Name	AGGF1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
568	ELKKIRVKYGLQNTE

Function

Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion

Protein Sequence

10 MASEAPSPPR 20 SPPPPTSPEP 30 ELAQLRRKVE 40 KLERELRSCK 50 RQVREIEKLL 60 HHTERLYQNA 70 ESNNQELRTQ 80 VEELSKILQR 90 GRNEDNKKSD 100 VEVQTENHAP 110 WSISDYFYQT 120 YYNDVSLPNK 130 VTELSDQQDQ 140 AIETSILNSK 150 DHLQVENDAY 160 PGTDRTENVK 170 YRQVDHFASN 180 SQEPASALAT 190 EDTSLEGSSL 200 AESLRAAAEA 210 AVSQTGFSYD 220 ENTGLYFDHS 230 TGFYYDSENQ 240 LYYDPSTGIY 250 YYCDVESGRY 260 QFHSRVDLQP 270 YPTSSTKQSK 280 DKKLKKKRKD 290 PDSSATNEEK 300 DLNSEDQKAF 310 SVEHTSCNEE 320 ENFANMKKKA 330 KIGIHHKNSP 340 PKVTVPTSGN 350 TIESPLHENI 360 SNSTSFKDEK 370 IMETDSEPEE 380 GEITDSQTED 390 SYDEAITSEG 400 NVTAEDSEDE 410 DEDKIWPPCI 420 RVIVIRSPVL 430 QIGSLFIITA 440 VNPATIGREK 450 DMEHTLRIPE 460 VGVSKFHAEI 470 YFDHDLQSYV 480 LVDQGSQNGT 490 IVNGKQILQP 500 KTKCDPYVLE 510 HGDEVKIGET 520 VLSFHIHPGS 530 DTCDGCEPGQ 540 VRAHLRLDKK 550 DESFVGPTLS 560 KEEKELERRK 570 ELKKIRVKYG 580 LQNTEYEDEK 590 TLKNPKYKDR 600 AGKRREQVGS 610 EGTFQRDDAP 620 ASVHSEITDS 630 NKGRKMLEKM 640 GWKKGEGLGK 650 DGGGMKTPIQ 660 LQLRRTHAGL 670 GTGKPSSFED 680 VHLLQNKNKK 690 NWDKARERFT 700 ENFPETKPQK 710 DDPGTMPWVK GTLE

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0048471	perinuclear region of cytoplasm
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0003676	nucleic acid binding
Biological Process	GO:0001525	angiogenesis
Biological Process	GO:0007155	cell adhesion
Biological Process	GO:0045766	positive regulation of angiogenesis
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation
Biological Process	GO:0001570	vasculogenesis

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.