Search Results
Overview
| Uniprot ID | Q8N335 |
|---|---|
| Protein Name | Glycerol-3-phosphate dehydrogenase 1-like protein |
| Gene Name | GPD1L |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 291 | KTIEELEKEMLNGQK |
Function
Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L
Protein Sequence
10
MAAAPLKVCI
20
VGSGNWGSAV
30
AKIIGNNVKK
40
LQKFASTVKM
50
WVFEETVNGR
60
KLTDIINNDH
70
ENVKYLPGHK
80
LPENVVAMSN
90
LSEAVQDADL
100
LVFVIPHQFI
110
HRICDEITGR
120
VPKKALGITL
130
IKGIDEGPEG
140
LKLISDIIRE
150
KMGIDISVLM
160
GANIANEVAA
170
EKFCETTIGS
180
KVMENGLLFK
190
ELLQTPNFRI
200
TVVDDADTVE
210
LCGALKNIVA
220
VGAGFCDGLR
230
CGDNTKAAVI
240
RLGLMEMIAF
250
ARIFCKGQVS
260
TATFLESCGV
270
ADLITTCYGG
280
RNRRVAEAFA
290
RTGKTIEELE
300
KEMLNGQKLQ
310
GPQTSAEVYR
320
ILKQKGLLDK
330
FPLFTAVYQI
340
CYESRPVQEM
350
LSCLQSHPEH
T
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0051287 | NAD binding |
| Molecular Function | GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0017080 | sodium channel regulator activity |
| Molecular Function | GO:0044325 | transmembrane transporter binding |
| Biological Process | GO:0005975 | carbohydrate metabolic process |
| Biological Process | GO:0046168 | glycerol-3-phosphate catabolic process |
| Biological Process | GO:0019674 | NAD+ metabolic process |
| Biological Process | GO:2000010 | positive regulation of protein localization to cell surface |
| Biological Process | GO:0010765 | positive regulation of sodium ion transport |
| Biological Process | GO:0002027 | regulation of heart rate |
| Biological Process | GO:0060373 | regulation of ventricular cardiac muscle cell membrane depolarization |
| Biological Process | GO:0086005 | ventricular cardiac muscle cell action potential |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.