Search Results
Overview
| Uniprot ID | Q8N392 |
|---|---|
| Protein Name | Rho GTPase-activating protein 18 |
| Gene Name | ARHGAP18 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 164 | QTLRKKNKQYQIPDV |
| 255 | KEKIQKSKGDDATLP |
Function
Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state (PubMed:21865595). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1 (PubMed:25778702). Regulates cell shape, spreading, and migration (PubMed:21865595)
Protein Sequence
10
MSWLSSSQGV
20
VLTAYHPSGK
30
DQTVGNSHAK
40
AGEEATSSRR
50
YGQYTMNQES
60
TTIKVMEKPP
70
FDRSISQDSL
80
DELSMEDYWI
90
ELENIKKSSE
100
NSQEDQEVVV
110
VKEPDEGELE
120
EEWLKEAGLS
130
NLFGESAGDP
140
QESIVFLSTL
150
TRTQAAAVQK
160
RVETVSQTLR
170
KKNKQYQIPD
180
VRDIFAQQRE
190
SKETAPGGTE
200
SQSLRTNENK
210
YQGRDDEASN
220
LVGEEKLIPP
230
EETPAPETDI
240
NLEVSFAEQA
250
LNQKESSKEK
260
IQKSKGDDAT
270
LPSFRLPKDK
280
TGTTRIGDLA
290
PQDMKKVCHL
300
ALIELTALYD
310
VLGIELKQQK
320
AVKIKTKDSG
330
LFCVPLTALL
340
EQDQRKVPGM
350
RIPLIFQKLI
360
SRIEERGLET
370
EGLLRIPGAA
380
IRIKNLCQEL
390
EAKFYEGTFN
400
WESVKQHDAA
410
SLLKLFIREL
420
PQPLLSVEYL
430
KAFQAVQNLP
440
TKKQQLQALN
450
LLVILLPDAN
460
RDTLKALLEF
470
LQRVIDNKEK
480
NKMTVMNVAM
490
VMAPNLFMCH
500
ALGLKSSEQR
510
EFVMAAGTAN
520
TMHLLIKYQK
530
LLWTIPKFIV
540
NQVRKQNTEN
550
HKKDKRAMKK
560
LLKKMAYDRE
570
KYEKQDKSTN
580
DADVPQGVIR
590
VQAPHLSKVS
600
MAIQLTEELK
610
ASDVLARFLS
620
QESGVAQTLK
630
KGEVFLYEIG
640
GNIGERCLDD
650
DTYMKDLYQL
660
NPNAEWVIKS
KPL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005881 | cytoplasmic microtubule |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0001726 | ruffle |
| Molecular Function | GO:0045296 | cadherin binding |
| Molecular Function | GO:0005096 | GTPase activator activity |
| Biological Process | GO:0032956 | regulation of actin cytoskeleton organization |
| Biological Process | GO:0030833 | regulation of actin filament polymerization |
| Biological Process | GO:2000145 | regulation of cell motility |
| Biological Process | GO:0008360 | regulation of cell shape |
| Biological Process | GO:0051056 | regulation of small GTPase mediated signal transduction |
| Biological Process | GO:0007264 | small GTPase-mediated signal transduction |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.