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Overview

Uniprot IDQ8N3F8
Protein NameMICAL-like protein 1
Gene NameMICALL1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
289 TKPRVPGKLQELASP
307 RPTPAPRKASESTTP
631 LQVKSSCKENPFNRK
649 AASPATKKATKGSKP
846 FKTMKMLKLLGNKRD

Function

Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity)

Protein Sequence

10 MAGPRGALLA 20 WCRRQCEGYR 30 GVEIRDLSSS 40 FRDGLAFCAI 50 LHRHRPDLLD 60 FDSLSKDNVF 70 ENNRLAFEVA 80 EKELGIPALL 90 DPNDMVSMSV 100 PDCLSIMTYV 110 SQYYNHFCSP 120 GQAGVSPPRK 130 GLAPCSPPSV 140 APTPVEPEDV 150 AQGEELSSGS 160 LSEQGTGQTP 170 SSTCAACQQH 180 VHLVQRYLAD 190 GRLYHRHCFR 200 CRRCSSTLLP 210 GAYENGPEEG 220 TFVCAEHCAR 230 LGPGTRSGTR 240 PGPFSQPKQQ 250 HQQQLAEDAK 260 DVPGGGPSSS 270 APAGAEADGP 280 KASPEARPQI 290 PTKPRVPGKL 300 QELASPPAGR 310 PTPAPRKASE 320 STTPAPPTPR 330 PRSSLQQENL 340 VEQAGSSSLV 350 NGRLHELPVP 360 KPRGTPKPSE 370 GTPAPRKDPP 380 WITLVQAEPK 390 KKPAPLPPSS 400 SPGPPSQDSR 410 QVENGGTEEV 420 AQPSPTASLE 430 SKPYNPFEEE 440 EEDKEEEAPA 450 APSLATSPAL 460 GHPESTPKSL 470 HPWYGITPTS 480 SPKTKKRPAP 490 RAPSASPLAL 500 HASRLSHSEP 510 PSATPSPALS 520 VESLSSESAS 530 QTAGAELLEP 540 PAVPKSSSEP 550 AVHAPGTPGN 560 PVSLSTNSSL 570 ASSGELVEPR 580 VEQMPQASPG 590 LAPRTRGSSG 600 PQPAKPCSGA 610 TPTPLLLVGD 620 RSPVPSPGSS 630 SPQLQVKSSC 640 KENPFNRKPS 650 PAASPATKKA 660 TKGSKPVRPP 670 APGHGFPLIK 680 RKVQADQYIP 690 EEDIHGEMDT 700 IERRLDALEH 710 RGVLLEEKLR 720 GGLNEGREDD 730 MLVDWFKLIH 740 EKHLLVRRES 750 ELIYVFKQQN 760 LEQRQADVEY 770 ELRCLLNKPE 780 KDWTEEDRAR 790 EKVLMQELVT 800 LIEQRNAIIN 810 CLDEDRQREE 820 EEDKMLEAMI 830 KKKEFQREAE 840 PEGKKKGKFK 850 TMKMLKLLGN 860 KRDAKSKSPR DKS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005912 adherens junction
Cellular Component GO:0030054 cell junction
Cellular Component GO:0034451 centriolar satellite
Cellular Component GO:0005814 centriole
Cellular Component GO:0060170 ciliary membrane
Cellular Component GO:0005929 cilium
Cellular Component GO:0010009 cytoplasmic side of endosome membrane
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005770 late endosome
Cellular Component GO:0031902 late endosome membrane
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0055038 recycling endosome membrane
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0008093 cytoskeletal anchor activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0070300 phosphatidic acid binding
Molecular Function GO:0031267 small GTPase binding
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0002042 cell migration involved in sprouting angiogenesis
Biological Process GO:0060271 cilium assembly
Biological Process GO:0032456 endocytic recycling
Biological Process GO:0006897 endocytosis
Biological Process GO:0031175 neuron projection development
Biological Process GO:0097320 plasma membrane tubulation
Biological Process GO:0061512 protein localization to cilium
Biological Process GO:0036010 protein localization to endosome
Biological Process GO:0006612 protein targeting to membrane
Biological Process GO:0015031 protein transport
Biological Process GO:0006898 receptor-mediated endocytosis
Biological Process GO:0032458 slow endocytic recycling

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.