Search Results

Overview

Uniprot ID	Q8N3P4
Protein Name	Vacuolar protein sorting-associated protein 8 homolog
Gene Name	VPS8
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
637	GITPQVMKDLIVHFQ

Function

Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:25266290). Functions predominantly in APPL1-containing endosomes (PubMed:25266290)

Protein Sequence

10 MENEPDHENV 20 EQSLCAKTSE 30 EELNKSFNLE 40 ASLSKFSYID 50 MDKELEFKND 60 LIDDKEFDIP 70 QVDTPPTLES 80 ILNETDDEDE 90 SFILEDPTLL 100 NIDTIDSHSY 110 DTSSVASSDS 120 GDRTNLKRKK 130 KLPDSFSLHG 140 SVMRHSLLKG 150 ISAQIVSAAD 160 KVDAGLPTAI 170 AVSSLIAVGT 180 SHGLALIFGK 190 DQNQALRLCL 200 GSTSVGGQYG 210 AISALSINND 220 CSRLLCGFAK 230 GQITMWDLAS 240 GKLLRSITDA 250 HPPGTAILHI 260 KFTDDPTLAI 270 CNDSGGSVFE 280 LTFKRVMGVR 290 TCESRCLFSG 300 SKGEVCCIEP 310 LHSKPELKDH 320 PITQFSLLAM 330 ASLTKILVIG 340 LKPSLKVWMT 350 FPYGRMDPSS 360 VPLLAWHFVA 370 VQNYVNPMLA 380 FCRGDVVHFL 390 LVKRDESGAI 400 HVTKQKHLHL 410 YYDLINFTWI 420 NSRTVVLLDS 430 VEKLHVIDRQ 440 TQEELETVEI 450 SEVQLVYNSS 460 HFKSLATGGN 470 VSQALALVGE 480 KACYQSISSY 490 GGQIFYLGTK 500 SVYVMMLRSW 510 RERVDHLLKQ 520 DCLTEALALA 530 WSFHEGKAKA 540 VVGLSGDASK 550 RKAIVADRMV 560 EILFHYADRA 570 LKKCPDQGKI 580 QVMEQHFQDM 590 VPVIVDYCLL 600 LQRKDLLFSQ 610 MYDKLSENSV 620 AKGVFLECLE 630 PYILSDKLVG 640 ITPQVMKDLI 650 VHFQDKKLME 660 NVEALIVHMD 670 ITSLDIQQVV 680 LMCWENRLYD 690 AMIYVYNRGM 700 NEFISPMEKL 710 FRVIAPPLNA 720 GKTLTDEQVV 730 MGNKLLVYIS 740 CCLAGRAYPL 750 GDIPEDLVPL 760 VKNQVFEFLI 770 RLHSAEASPE 780 EEIYPYIRTL 790 LHFDTREFLN 800 VLALTFEDFK 810 NDKQAVEYQQ 820 RIVDILLKVM 830 VENSDFTPSQ 840 VGCLFTFLAR 850 QLAKPDNTLF 860 VNRTLFDQVL 870 EFLCSPDDDS 880 RHSERQQVLL 890 ELLQAGGIVQ 900 FEESRLIRMA 910 EKAEFYQICE 920 FMYEREHQYD 930 KIIDCYLRDP 940 LREEEVFNYI 950 HNILSIPGHS 960 AEEKQSVWQK 970 AMDHIEELVS 980 LKPCKAAELV 990 ATHFSGHIET 1000 VIKKLQNQVL 1010 LFKFLRSLLD 1020 PREGIHVNQE 1030 LLQISPCITE 1040 QFIELLCQFN 1050 PTQVIETLQV 1060 LECYRLEETI 1070 QITQKYQLHE 1080 VTAYLLEKKG 1090 DIHGAFLIML 1100 ERLQSKLQEV 1110 THQGENTKED 1120 PSLKDVEDTM 1130 VETIALCQRN 1140 SHNLNQQQRE 1150 ALWFPLLEAM 1160 MAPQKLSSSA 1170 IPHLHSEALK 1180 SLTMQVLNSM 1190 AAFIALPSIL 1200 QRILQDPVYG 1210 KGKLGEIQGL 1220 ILGMLDTFNY 1230 EQTLLETTTS 1240 LLNQDLHWSL 1250 CNLRASVTRG 1260 LNPKQDYCSI 1270 CLQQYKRRQE 1280 MADEIIVFSC 1290 GHLYHSFCLQ 1300 NKECTVEFEG 1310 QTRWTCYKCS 1320 SSNKVGKLSE 1330 NSSEIKKGRI 1340 TPSQVKMSPS 1350 YHQSKGDPTA 1360 KKGTSEPVLD 1370 PQQIQAFDQL 1380 CRLYRGSSRL 1390 ALLTELSQNR 1400 SSESYRPFSG 1410 SQSAPAFNSI 1420 FQNENFQLQL IPPPVTED

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0033263	CORVET complex
Cellular Component	GO:0005769	early endosome
Cellular Component	GO:0005770	late endosome
Molecular Function	GO:0043495	protein-membrane adaptor activity
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0034058	endosomal vesicle fusion
Biological Process	GO:0006623	protein targeting to vacuole
Biological Process	GO:0035542	regulation of SNARE complex assembly

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.