Overview
| Uniprot ID | Q8N3R9 |
|---|
| Protein Name | Protein PALS1 |
|---|
| Gene Name | PALS1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 447 |
KNKKKRKKVLYNANK |
Function
Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (PubMed:16678097, PubMed:25385611). Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface (By similarity). Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (PubMed:27466317). Required during embryonic and postnatal retinal development (By similarity). Required for the maintenance of cerebellar progenitor cells in an undifferentiated proliferative state, preventing premature differentiation, and is required for cerebellar histogenesis, fissure formation, cerebellar layer organization and cortical development (By similarity). Plays a role in neuronal progenitor cell survival, potentially via promotion of mTOR signaling (By similarity). Plays a role in the radial and longitudinal extension of the myelin sheath in Schwann cells (By similarity). May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter (By similarity). Plays a role in the T-cell receptor-mediated activation of NF-kappa-B (PubMed:21479189). Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity). Required for the normal polarized localization of the vesicular marker STX4 (By similarity). Required for the correct trafficking of the myelin proteins PMP22 and MAG (By similarity). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity)
Protein Sequence
10
MTTSHMNGHV
20
TEESDSEVKN
30
VDLASPEEHQ
40
KHREMAVDCP
50
GDLGTRMMPI
60
RRSAQLERIR
70
QQQEDMRRRR
80
EEEGKKQELD
90
LNSSMRLKKL
100
AQIPPKTGID
110
NPMFDTEEGI
120
VLESPHYAVK
130
ILEIEDLFSS
140
LKHIQHTLVD
150
SQSQEDISLL
160
LQLVQNKDFQ
170
NAFKIHNAIT
180
VHMNKASPPF
190
PLISNAQDLA
200
QEVQTVLKPV
210
HHKEGQELTA
220
LLNTPHIQAL
230
LLAHDKVAEQ
240
EMQLEPITDE
250
RVYESIGQYG
260
GETVKIVRIE
270
KARDIPLGAT
280
VRNEMDSVII
290
SRIVKGGAAE
300
KSGLLHEGDE
310
VLEINGIEIR
320
GKDVNEVFDL
330
LSDMHGTLTF
340
VLIPSQQIKP
350
PPAKETVIHV
360
KAHFDYDPSD
370
DPYVPCRELG
380
LSFQKGDILH
390
VISQEDPNWW
400
QAYREGDEDN
410
QPLAGLVPGK
420
SFQQQREAMK
430
QTIEEDKEPE
440
KSGKLWCAKK
450
NKKKRKKVLY
460
NANKNDDYDN
470
EEILTYEEMS
480
LYHQPANRKR
490
PIILIGPQNC
500
GQNELRQRLM
510
NKEKDRFASA
520
VPHTTRSRRD
530
QEVAGRDYHF
540
VSRQAFEADI
550
AAGKFIEHGE
560
FEKNLYGTSI
570
DSVRQVINSG
580
KICLLSLRTQ
590
SLKTLRNSDL
600
KPYIIFIAPP
610
SQERLRALLA
620
KEGKNPKPEE
630
LREIIEKTRE
640
MEQNNGHYFD
650
TAIVNSDLDK
660
AYQELLRLIN
670
KLDTEPQWVP
STWLR
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005912 |
adherens junction |
| Cellular Component |
GO:0043296 |
apical junction complex |
| Cellular Component |
GO:0016324 |
apical plasma membrane |
| Cellular Component |
GO:0030424 |
axon |
| Cellular Component |
GO:0005923 |
bicellular tight junction |
| Cellular Component |
GO:0030054 |
cell junction |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0033116 |
endoplasmic reticulum-Golgi intermediate compartment membrane |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0043219 |
lateral loop |
| Cellular Component |
GO:0035749 |
myelin sheath adaxonal region |
| Cellular Component |
GO:0043204 |
perikaryon |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0032991 |
protein-containing complex |
| Cellular Component |
GO:0043220 |
Schmidt-Lanterman incisure |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0019904 |
protein domain specific binding |
| Biological Process |
GO:0021954 |
central nervous system neuron development |
| Biological Process |
GO:0021987 |
cerebral cortex development |
| Biological Process |
GO:0045197 |
establishment or maintenance of epithelial cell apical/basal polarity |
| Biological Process |
GO:0016332 |
establishment or maintenance of polarity of embryonic epithelium |
| Biological Process |
GO:0048699 |
generation of neurons |
| Biological Process |
GO:0002011 |
morphogenesis of an epithelial sheet |
| Biological Process |
GO:0032288 |
myelin assembly |
| Biological Process |
GO:0032287 |
peripheral nervous system myelin maintenance |
| Biological Process |
GO:0035750 |
protein localization to myelin sheath abaxonal region |
| Biological Process |
GO:0072659 |
protein localization to plasma membrane |
| Biological Process |
GO:0017015 |
regulation of transforming growth factor beta receptor signaling pathway |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.