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Overview

Uniprot IDQ8N3V7
Protein NameSynaptopodin
Gene NameSYNPO
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
594 LYPSSDPKSSHLKGQ
607 GQAVPASKTGILEES

Function

Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity)

Protein Sequence

10 MLGPHLPPPP 20 LAPSEGRPTP 30 CAFQIPDGSY 40 RCLALEAEES 50 SGEEGLQGEV 60 GPTDLEEDEG 70 VSRSGDDSAC 80 RVTQGTPQLP 90 KALGIQPPSC 100 SREEQGASQH 110 DDRASQDWDV 120 VKAGQMMTAS 130 PSPGPGPRVA 140 QKPALGRSTS 150 LTEKDLKEAK 160 ARSQQIAAQL 170 TTPPSSNSRG 180 VQLFNRRRQR 190 VNEFTLESHG 200 QRGQKPSQES 210 LRVLPSSLPG 220 HAPGLSLSST 230 SLPEPGPPRH 240 PSPQSPDRGV 250 PGHSMEGYSE 260 EASLLRHLEK 270 VASEEEEVPL 280 VVYLKENAAL 290 LTANGLHLSQ 300 NREAQQSSPA 310 PPPAEVHSPA 320 ADVNQNLASP 330 SATLTTPTSN 340 SSHNPPATDV 350 NQNPPATVVP 360 QSLPLSSIQQ 370 NSSEAQLPSN 380 GTGPASKPST 390 LCADGQPQAP 400 AEEVRCSTLL 410 IDKVSTPATT 420 TSTFSREATL 430 IPSSRPPASD 440 FMSSSLLIDI 450 QPNTLVVSAD 460 QEMSGRAAAT 470 TPTKVYSEVH 480 FTLAKPPSVV 490 NRTARPFGIQ 500 APGGTSQMER 510 SPMLERRHFG 520 EKAPAPQPPS 530 LPDRSPRPQR 540 HIMSRSPMVE 550 RRMMGQRSPA 560 SERRPLGNFT 570 APPTYTETLS 580 TAPLASWVRS 590 PPSYSVLYPS 600 SDPKSSHLKG 610 QAVPASKTGI 620 LEESMARRGS 630 RKSMFTFVEK 640 PKVTPNPDLL 650 DLVQTADEKR 660 RQRDQGEVGV 670 EEEPFALGAE 680 ASNFQQEPAP 690 RDRASPAAAE 700 EVVPEWASCL 710 KSPRIQAKPK 720 PKPNQNLSEA 730 SGKGAELYAR 740 RQSRMEKYVI 750 ESSSHTPELA 760 RCPSPTMSLP 770 SSWKYPTNAP 780 GAFRVASRSP 790 ARTPPASLYH 800 GYLPENGVLR 810 PEPTKQPPYQ 820 LRPSLFVLSP 830 IKEPAKVSPR 840 AASPAKPSSL 850 DLVPNLPKGA 860 LPPSPALPRP 870 SRSSPGLYTS 880 PGQDSLQPTA 890 VSPPYGGDIS 900 PVSPSRAWSP 910 RAKQAPRPSF 920 STRNAGIEAQ VWKPSFCFK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0005923 bicellular tight junction
Cellular Component GO:0005829 cytosol
Cellular Component GO:0043197 dendritic spine
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0005634 nucleus
Cellular Component GO:0043204 perikaryon
Cellular Component GO:0014069 postsynaptic density
Cellular Component GO:0097444 spine apparatus
Cellular Component GO:0001725 stress fiber
Cellular Component GO:0030018 Z disc
Molecular Function GO:0003779 actin binding
Biological Process GO:0032233 positive regulation of actin filament bundle assembly
Biological Process GO:0051492 regulation of stress fiber assembly
Biological Process GO:1905355 spine apparatus assembly

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.