Search Results

Overview

Uniprot ID	Q8N488
Protein Name	RING1 and YY1-binding protein
Gene Name	RYBP
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
104	EISPSVTKKNTNKKT
105	ISPSVTKKNTNKKTK
119	KPKSDILKDPPSEAN

Function

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (By similarity). Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes (PubMed:19098711). May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis (PubMed:14765135, PubMed:27060496). May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 (PubMed:11953439). May bind to DNA (By similarity). May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3 (PubMed:27748911)

Protein Sequence

10 MTMGDKKSPT 20 RPKRQAKPAA 30 DEGFWDCSVC 40 TFRNSAEAFK 50 CSICDVRKGT 60 STRKPRINSQ 70 LVAQQVAQQY 80 ATPPPPKKEK 90 KEKVEKQDKE 100 KPEKDKEISP 110 SVTKKNTNKK 120 TKPKSDILKD 130 PPSEANSIQS 140 ANATTKTSET 150 NHTSRPRLKN 160 VDRSTAQQLA 170 VTVGNVTVII 180 TDFKEKTRSS 190 STSSSTVTSS 200 AGSEQQNQSS 210 SGSESTDKGS 220 SRSSTPKGDM SAVNDESF

Gene Ontology

Classification	GO ID	Description
Biological Process	GO:0043065	positive regulation of apoptotic process
Biological Process	GO:0045893	positive regulation of DNA-templated transcription
Biological Process	GO:0006355	regulation of DNA-templated transcription
Cellular Component	GO:0000785	chromatin
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0031519	PcG protein complex
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0003676	nucleic acid binding
Molecular Function	GO:0003712	transcription coregulator activity
Molecular Function	GO:0003714	transcription corepressor activity
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0006915	apoptotic process
Biological Process	GO:0006338	chromatin remodeling
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0031507	heterochromatin formation
Biological Process	GO:0045892	negative regulation of DNA-templated transcription
Biological Process	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.