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Overview

Uniprot ID	Q8N556
Protein Name	Actin filament-associated protein 1
Gene Name	AFAP1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
326	VTGKKITKIISLGKK
536	TLSSQPKKADPAAVV

Function

Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells

Protein Sequence

10 MEELIVELRL 20 FLELLDHEYL 30 TSTVREKKAV 40 ITNILLRIQS 50 SKGFDVKDHA 60 QKQETANSLP 70 APPQMPLPEI 80 PQPWLPPDSG 90 PPPLPTSSLP 100 EGYYEEAVPL 110 SPGKAPEYIT 120 SNYDSDAMSS 130 SYESYDEEEE 140 DGKGKKTRHQ 150 WPSEEASMDL 160 VKDAKICAFL 170 LRKKRFGQWT 180 KLLCVIKDTK 190 LLCYKSSKDQ 200 QPQMELPLQG 210 CNITYIPKDS 220 KKKKHELKIT 230 QQGTDPLVLA 240 VQSKEQAEQW 250 LKVIKEAYSG 260 CSGPVDSECP 270 PPPSSPVHKA 280 ELEKKLSSER 290 PSSDGEGVVE 300 NGITTCNGKE 310 QVKRKKSSKS 320 EAKGTVSKVT 330 GKKITKIISL 340 GKKKPSTDEQ 350 TSSAEEDVPT 360 CGYLNVLSNS 370 RWRERWCRVK 380 DNKLIFHKDR 390 TDLKTHIVSI 400 PLRGCEVIPG 410 LDSKHPLTFR 420 LLRNGQEVAV 430 LEASSSEDMG 440 RWIGILLAET 450 GSSTDPEALH 460 YDYIDVEMSA 470 SVIQTAKQTF 480 CFMNRRVISA 490 NPYLGGTSNG 500 YAHPSGTALH 510 YDDVPCINGS 520 LKGKKPPVAS 530 NGVTGKGKTL 540 SSQPKKADPA 550 AVVKRTGSNA 560 AQYKYGKNRV 570 EADAKRLQTK 580 EEELLKRKEA 590 LRNRLAQLRK 600 ERKDLRAAIE 610 VNAGRKPQAI 620 LEEKLKQLEE 630 ECRQKEAERV 640 SLELELTEVK 650 ESLKKALAGG 660 VTLGLAIEPK 670 SGTSSPQSPV 680 FRHRTLENSP 690 ISSCDTSDTE 700 GPVPVNSAAV 710 LKKSQAAPGS 720 SPCRGHVLRK 730 AKEWELKNGT

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0015629	actin cytoskeleton
Cellular Component	GO:0005884	actin filament
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005925	focal adhesion
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0001725	stress fiber
Molecular Function	GO:0003779	actin binding
Molecular Function	GO:0060090	molecular adaptor activity
Biological Process	GO:0009966	regulation of signal transduction

Reference

[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.