Search Results

Overview

Uniprot ID	Q8N573
Protein Name	Oxidation resistance protein 1
Gene Name	OXR1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
32	NPLAGAGKQTPQASK

Function

Inhibits the activity of the vacuolar-type ATPase (V-ATPase) by inducing disassembly of the V-ATPase complex (PubMed:38593795). Protects the Golgi apparatus lumen from excess acidification by inhibiting V-ATPase ATP hydrolytic activity through interaction with V-ATPase catalytic subunit ATP6V1A, maintaining optimal conditions for glycosylation enzymes (By similarity). Involved in protection from oxidative damage (PubMed:11114193, PubMed:15060142). Protects neuronal cells from oxidative stress (By similarity)

Protein Sequence

10 MTKDKNSPGL 20 KKKSQSVDIN 30 APGFNPLAGA 40 GKQTPQASKP 50 PAPKTPIIEE 60 EQNNAANTQK 70 HPSRRSELKR 80 FYTIDTGQKK 90 TLDKKDGRRM 100 SFQKPKGTIE 110 YTVESRDSLN 120 SIALKFDTTP 130 NELVQLNKLF 140 SRAVVTGQVL 150 YVPDPEYVSS 160 VESSPSLSPV 170 SPLSPTSSEA 180 EFDKTTNPDV 190 HPTEATPSST 200 FTGIRPARVV 210 SSTSEEEEAF 220 TEKFLKINCK 230 YITSGKGTVS 240 GVLLVTPNNI 250 MFDPHKNDPL 260 VQENGCEEYG 270 IMCPMEEVMS 280 AAMYKEILDS 290 KIKESLPIDI 300 DQLSGRDFCH 310 SKKMTGSNTE 320 EIDSRIRDAG 330 NDSASTAPRS 340 TEESLSEDVF 350 TESELSPIRE 360 ELVSSDELRQ 370 DKSSGASSES 380 VQTVNQAEVE 390 SLTVKSESTG 400 TPGHLRSDTE 410 HSTNEVGTLC 420 HKTDLNNLEM 430 AIKEDQIADN 440 FQGISGPKED 450 STSIKGNSDQ 460 DSFLHENSLH 470 QEESQKENMP 480 CGETAEFKQK 490 QSVNKGKQGK 500 EQNQDSQTEA 510 EELRKLWKTH 520 TMQQTKQQRE 530 NIQQVSQKEA 540 KHKITSADGH 550 IESSALLKEK 560 QRHRLHKFLC 570 LRVGKPMRKT 580 FVSQASATMQ 590 QYAQRDKKHE 600 YWFAVPQERT 610 DHLYAFFIQW 620 SPEIYAEDTG 630 EYTREPGFIV 640 VKKIEESETI 650 EDSSNQAAAR 660 EWEVVSVAEY 670 HRRIDALNTE 680 ELRTLCRRLQ 690 ITTREDINSK 700 QVATVKADLE 710 SESFRPNLSD 720 PSELLLPDQI 730 EKLTKHLPPR 740 TIGYPWTLVY 750 GTGKHGTSLK 760 TLYRTMTGLD 770 TPVLMVIKDS 780 DGQVFGALAS 790 EPLKVSDGFY 800 GTGETFVFTF 810 CPEFEVFKWT 820 GDNMFFIKGD 830 MDSLAFGGGG 840 GEFALWLDGD 850 LYHGRSHSCK 860 TFGNRTLSKK 870 EDFFIQDIEI WAFE

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0016491	oxidoreductase activity
Biological Process	GO:0006979	response to oxidative stress

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.