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Overview

Uniprot IDQ8N5A5
Protein NameZinc finger CCCH-type with G patch domain-containing protein
Gene NameZGPAT
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
383 QCVETLQKQTRVGKA
389 QKQTRVGKAGTNKPP
449 KDMYHASKSAKRALS
497 ASAQLQEKLAGAQRQ

Function

Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis

Protein Sequence

10 MDEESLESAL 20 QTYRAQLQQV 30 ELALGAGLDS 40 SEQADLRQLQ 50 GDLKELIELT 60 EASLVSVRKS 70 SLLAALDEER 80 PGRQEDAEYQ 90 AFREAITEAV 100 EAPAAARGSG 110 SETVPKAEAG 120 PESAAGGQEE 130 EEGEDEEELS 140 GTKVSAPYYS 150 SWGTLEYHNA 160 MVVGTEEAED 170 GSAGVRVLYL 180 YPTHKSLKPC 190 PFFLEGKCRF 200 KENCRFSHGQ 210 VVSLDELRPF 220 QDPDLSSLQA 230 GSACLAKHQD 240 GLWHAARITD 250 VDNGYYTVKF 260 DSLLLREAVV 270 EGDGILPPLR 280 TEATESDSDS 290 DGTGDSSYAR 300 VVGSDAVDSA 310 QSSALCPSLA 320 VVGSDAVDSG 330 TCSSAFAGWE 340 VHTRGIGSRL 350 LTKMGYEFGK 360 GLGRHAEGRV 370 EPIHAVVLPR 380 GKSLDQCVET 390 LQKQTRVGKA 400 GTNKPPRCRG 410 RGARPGGRPA 420 PRNVFDFLNE 430 KLQGQAPGAL 440 EAGAAPAGRR 450 SKDMYHASKS 460 AKRALSLRLF 470 QTEEKIERTQ 480 RDIRSIQEAL 490 ARNAGRHSVA 500 SAQLQEKLAG 510 AQRQLGQLRA 520 QEAGLQQEQR 530 KADTHKKMTE F

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003700 DNA-binding transcription factor activity
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0043565 sequence-specific DNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0007175 negative regulation of epidermal growth factor-activated receptor activity
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II

Reference

[1] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.