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Overview

Uniprot IDQ8N5C7
Protein NametRNA-uridine aminocarboxypropyltransferase 1
Gene NameDTWD1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
18 RSEENSSKFVETKQS

Function

Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20 in the D-loop of several cytoplasmic tRNAs (acp3U(20))

Protein Sequence

10 MSLNPPIFLK 20 RSEENSSKFV 30 ETKQSQTTSI 40 ASEDPLQNLC 50 LASQEVLQKA 60 QQSGRSKCLK 70 CGGSRMFYCY 80 TCYVPVENVP 90 IEQIPLVKLP 100 LKIDIIKHPN 110 ETDGKSTAIH 120 AKLLAPEFVN 130 IYTYPCIPEY 140 EEKDHEVALI 150 FPGPQSISIK 160 DISFHLQKRI 170 QNNVRGKNDD 180 PDKPSFKRKR 190 TEEQEFCDLN 200 DSKCKGTTLK 210 KIIFIDSTWN 220 QTNKIFTDER 230 LQGLLQVELK 240 TRKTCFWRHQ 250 KGKPDTFLST 260 IEAIYYFLVD 270 YHTDILKEKY 280 RGQYDNLLFF 290 YSFMYQLIKN 300 AKCSGDKETG KLTH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005634 nucleus
Molecular Function GO:0016432 tRNA-uridine aminocarboxypropyltransferase activity
Biological Process GO:0006400 tRNA modification

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.